ANÁLISIS DE SUPERVIVENCIA DE PACIENTES CON DIÁLISIS PERITONEAL

SURVIVAL DATA ANALYSIS OF PATIENTS WITH PERITONEAL DIALYSIS

Se realiza un análisis de supervivencia de pacientes que acudían al Servicio de Diálisis Peritoneal del Hospital Clínico Universitario de Caracas, Venezuela, entre los años 1980 y 1997, utilizando la muerte como evento de interés. El análisis incluye: estimaciones de las funciones de supervivencia mediante el estimador de Kaplan–Meier, obtención del mejor modelo semiparamétrico de riesgos proporcionales (modelo de Cox), verificación de los supuestos y análisis de residuos. El modelo de Cox incluye diabetes, edad y el índice de Quetellet como covariables.

A survival analysis in patients that assisted to the peritoneal dialysis service of the Hospital Clínico Universitario de Caracas, Venezuela, between 1980 y 1997, using death as event of interest is presented. Estimation of the survival function by the Kaplan-Meier estimator, Semi-parametric proportional hazard models (Cox models), verification of the assumptions of the models and residual analysis are included. In the Cox model, diabetes, age and Quetellet’s index are used as covariates.

Análisis de supervivencia de pacientes con diálisis peritoneal Survival Data Analysis of Patients with Peritoneal Dialysis RAFAEL EDUARDO BORGES P.¹

¹Profesor Agregado, Escuela de Estadística, Facultad de Ciencias Económicas y Sociales, Universidad de Los Andes, Mérida 5101, Venezuela. E-mail: borgesr@ula.ve

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Resumen

Se realiza un análisis de supervivencia de pacientes que acudían al Servicio de Diálisis Peritoneal del Hospital Clínico Universitario de Caracas, Venezuela, entre los años 1980 y 1997, utilizando la muerte como evento de interés. El análisis incluye: estimaciones de las funciones de supervivencia mediante el estimador de Kaplan-Meier, obtención del mejor modelo semiparam étrico de riesgos proporcionales (modelo de Cox), verificación de los supuestos y análisis de residuos. El modelo de Cox incluye diabetes, edad y el índice de Quetellet como covariables.

Palabras Clave: Análisis de supervivencia, estimador de Kaplan y Meier, modelo de riesgos proporcionales (modelo de Cox), diálisis peritoneal.

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Abstract

A survival analysis in patients that assisted to the peritoneal dialysis service of the Hospital Clínico Universitario de Caracas, Venezuela, between 1980 y 1997, using death as event of interest is presented. Estimation of the survival function by the Kaplan-Meier estimator, Semi-parametric proportional hazard models (Cox models), verification of the assumptions of the models and residual analysis are included. In the Cox model, diabetes, age and Quetellet"s index are used as covariates.

Keywords: Survival Analysis, Kaplan-Meier estimator, proportional hazard model (Cox model), continuous ambulatory peritoneal dialysis.

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