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Diagnóstico de neurofibroma intraóseo solitario mandibular. Un reporte de caso
Diagnosis of mandibular solitary intraosseous neurofibroma, a case report
DOI:
https://doi.org/10.15446/aoc.v13n1.102370Keywords:
neurofibromatosis, patología, : Etnicidad, intraóseo, informes de caso. (es)Neurofibromatosis, Pathology, Molecular, Neurofibroma intraosseous (en)
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Introducción: el neurofibroma es una neoplasia benigna de la vaina de los nervios periféricos, eventualmente asociada a la neurofibromatosis tipo I, también llamada enfermedad de Von Recklinghausen. Su presentación a nivel de cabeza y cuello es poco común, por lo cual existen pocos reportes. Objetivo: presentar un caso clínico con diagnóstico de neurofibroma intraóseo clínico y una revisión actualizada de la literatura. Una paciente de 46 años, tratada en un servicio de cirugía oral y maxilofacial de la ciudad de Bogotá, Colombia, con un diagnóstico de neurofibroma intraóseo solitario de tres meses de evolución, a quien se le descartó neurofibromatosis de Von Recklinghausen, el cual comprometía el cuerpo y la rama mandibular derecha. El diagnóstico se realizó utilizando imágenes diagnósticas, así como bloques y láminas para la revisión de la biopsia inicial y de la resección. Esto, con el fin de interpretar y realizar el diagnóstico histopatológico en el Servicio de Patología Oral y Maxilofacial de la Facultad de Odontología de la Universidad Nacional de Colombia (FOUN), donde se efectuaron cortes en coloración de hematoxilina y eosina y marcadores de inmunohistoquímica. Conclusión: el tratamiento realizado incluyó la resección quirúrgica de la lesión, injerto óseo y recubrimiento con membrana alogénica de dermis humana.
Neurofibroma is a benign neoplasm of the peripheral nerves sheath, eventually associated with neurofibromatosis type I, also called Von Recklinghausen disease, its presentation at the head and neck level is rare, therefore, reports are scarce. A clinical case with diagnosis of "Solitary intraosseous neurofibroma" ruling out Von Recklinghausen Neurofibromatosis by genetic studies in a 46-year-old female patient, which compromises the right mandibular body and ramus of three months of evolution is presented. Diagnostic images, blocks and slides were used for revision of the initial biopsy, cuts of the resection with hematoxylin and eosin staining and immunohistochemical markers were done for interpretation and histopathological diagnosis. The treatment performed included surgical resection of the lesion, bone graft, and allogeneic human dermis membrane coverage. The aim of this article is to present a case with diagnosis of clinical intraosseous neurofibroma and an updated review of the literature.
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