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Descripción matemática de la determinación electroanalítica del fármaco salvarsano y su ciclooligómeros, asistida por un compuesto del colorante escuárico y oxihidróxido de cobalto
The mathematical description of the electroanalytical determination of salvarsan drug and its cyclooligomers, assisted by the composite of squaraine dye with cobalt oxyhydroxide
A descrição matemática da determinação eletroanalítica do fármaco salvarsan e seus ciclo-oligômeros, auxiliada pela composição do corante esquaraína com oxihidróxido de cobalto
DOI:
https://doi.org/10.15446/rcciquifa.v50n1.95453Keywords:
Salvarsano, sensor electroquímico, oxihidróxido de cobalto, colorante escuárico, oscilaciones electroquímicas, estado estacionario estable (es)Salvarsan, sensor eletroquímico, oxihidróxido de cobalto, corante esquaraína, oscilações eletroquímicas, estado estacionário estável (pt)
Salvarsano, electrochemical sensor, cobalt oxyhydroxide, squaraine dye, electrochemical oscillations, stable steady-state (en)
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Objetivo: en este trabajo se realiza, por primera vez, la evaluación teórica de la posibilidad de la detección electroanalítica de salvarsano, fármaco antisifilítico. El oxihidróxido de cobalto, en su compuesto con el colorante escuárico, se usa como modificador de electrodo. Metodología: mediante el análisis de estabilidad, se ha confirmado su eficiencia en los procesos de detección de salvarsano. La linearidad de dependencia entre el parámetro electroquímico y la concentración del fármaco se obtiene y se mantiene fácilmente. Conclusión: las inestabilidades oscilatoria y monotónica se realizan en el sistema, causadas por las influencias de las etapas electroquímicas a las capacitancias de la doble capa eléctrica (DCE).
Aim: In this work, the theoretical evaluation of the electroanalytical detection of antisyphilitic drug salvarsan is given for the first time. Cobalt oxyhydroxide in a composite with the squaraine dye is used as electrode modifier. Methodology: By means of the stability analysis the efficiency of the salvarsan determination is confirmed. The linearity of the dependence between the electrochemical parameter and drug concentration is easily obtained and maintained. Conclusion: The oscillatory and monotonic instabilities are realized in this system, being caused by the electrochemical stages´ influences to the double electric layer (DEL).
Objetivo: neste trabalho, a avaliação teórica da detecção eletroanalítica do antissifilítico salvarsan é feita pela primeira vez. O oxihidróxido de cobalto em um composto com o corante esquaraína é usado como modificador de eletrodo. Metodologia: por meio da análise de estabilidade é confirmada a eficiência da determinação de salvarsan. A linearidade da dependência entre o parâmetro eletroquímico e a concentração do fármaco é facilmente obtida e mantida. Conclusão: as instabilidades oscilatórias e monotônicas são percebidas neste sistema, sendo causadas pelas influências dos estágios eletroquímicos sobre a dupla camada elétrica (DEL).
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