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Síntesis y caracterización del complejo tranexamato de plata (I) y su potencial actividad antibacteriana
Synthesis and Characterization of the Silver (I) Tranexamate Complex and its Potential Antibacterial Activity
Síntese e caracterização do complexo tranexamato de prata (I) e sua potencial atividade antibacteriana
DOI:
https://doi.org/10.15446/rev.colomb.quim.v55n1.124307Palabras clave:
Coordinación de plata , Ácido tranexámico, Staphyloccocus aureus (es)Silver coordination, Tranexamic acid, Staphyloccocus aureus (en)
Coordenação de prata, Ácido tranexâmico, Staphyloccocus aureus (pt)
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Se sintetizó un nuevo compuesto de coordinación de plata, derivado del ácido tranexámico (TXA), mediante la reacción del ligando con una sal de plata en medio acuoso. El producto obtenido se aisló como un sólido blanco con un rendimiento del 65% y se caracterizó mediante análisis elemental, espectroscopía infrarroja por transformada de Fourier (FT-IR), resonancia magnética nuclear de carbono 13C y análisis termogravimétrico (TGA). A partir del complejo sintetizado se formularon cremas aceite en agua (o/w) a concentraciones de 0,25; 0,50; 1,00 y 2,00%. La actividad antibacteriana se evaluó mediante el método de difusión en agar de Kirby-Bauer frente a Staphyloccocus aureus. La formulación al 2,00% presentó la mayor actividad antibacteriana, con un halo de inhibición promedio de 13,785 mm. Los resultados obtenidos evidencian que el complejo de plata (I) derivado de TXA tiene potencial como agente antibacteriano para el desarrollo de fórmulas tópicas con aplicaciones farmacéuticas y dermatológicas.
A new silver coordination compound, derived from tranexamic acid (TXA), was synthesized by reacting the ligand with a silver salt in an aqueous medium. The resulting product was isolated as a white solid with a 65% yield and was characterized by elemental analysis, Fourier transform infrared spectroscopy (FT-IR), carbon nuclear magnetic resonance 13C, and thermogravimetric analysis (TGA). From the synthesized complex, oil-in-water (o/w) creams were formulated at concentrations of 0,25; 0,50; 1,00 and 2,00%. The antibacterial activity was evaluated using the Kirby-Bauer agar diffusion method against Staphylococcus aureus. The 2,00% formulation showed the highest antibacterial activity, with an average inhibition zone of 13.785 mm. The results obtained indicate that the TXA-derived silver (I) complex has potential as an antibacterial agent for the development of topical formulations with pharmaceutical and dermatological applications.
Foi sintetizado um novo composto de coordenação de prata, derivado do ácido tranexâmico (TXA), pela reação do ligando com um sal de prata em meio aquoso. O produto obtido foi isolado como um sólido branco com um rendimento de 65% e caracterizado através de análise elementar, espectroscopia de infravermelhos por transformada de Fourier (FT-IR), ressonância magnética nuclear de carbono 13C e análise termogravimétrica (TGA). A partir do complexo sintetizado foram formulados cremes óleo-em-água (o/w) em concentrações de 0,25; 0,50; 1,00 e 2,00%. A atividade antibacteriana foi avaliada através do método de difusão em ágar de Kirby-Bauer contra Staphylococcus aureus. A formulação a 2,00% apresentou a maior atividade antibacteriana, com um halo de inibição médio de 13,785 mm. Os resultados obtidos evidenciam que o complexo de prata (I) derivado do TXA tem potencial como agente antibacteriano para o desenvolvimento de formulações tópicas com aplicações farmacêuticas dermatológicas.
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Derechos de autor 2026 Guillermo José Gallardo Vásquez, Milca Yeni Choque Díaz
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