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Evaluación de las condiciones de detoxificación de la toxina tetánica
Evaluation of detoxification conditions of tetanus toxin
Keywords:
Detoxificación, toxoide tetánico, toxina tetánica, formaldehído (es)Detoxification, tetanus toxoid, tetanus toxin, formaldehyde (en)
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La transformación a toxoide de la toxina tetánica sin purificar y libre de células, se evaluó bajo condiciones variables de pH, temperatura de incubación inicial (primera semana), potencial de óxido-reducción, concentración de toxina tetánica y concentración de formaldehído. Al tratar la toxina tetánica en un medio de reacción neutro existe menor porcentaje de pérdida de la proteína tetánica. Para las condiciones actuales de detoxificación, no existe dependencia de la concentración de formaldehído y la concentración de proteína tetánica inicial, variando de forma independiente el valor floculante. La reacción formaldehídotoxina es lenta a bajas temperaturas, con menor disminución del valor floculante y sin influencia del potencial redox en el valor floculante y en la pérdida de toxicidad.
The transformation to toxoid of tetanus toxin without purification and cells free, was evaluated under variable conditions such as pH, initial incubation temperature (first week), potencial of oxidation-reduction, tetanus toxin concentration and formaldehyde concentration. When tetanus toxin is treated in a neutral reactional media there is a less lost of tetanus protein. To the present detoxification conditions there is not dependence between the formaldehyde concentration and the initial tetanus protein concentration changing independtly the flocculant value. The formaldehyde-toxin reaction is slow at low temperatures, with a lower diminution of the flocculant value and without the redox potential influence in the flocculant value and in the lost of toxicity.
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Copyright (c) 1999 Revista Colombiana de Biotecnología
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