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Sarcoma felino posvacunal (FISS), reporte de caso en Colombia
Feline postvaccinal sarcoma (FISS), case report in Colombia
DOI:
https://doi.org/10.15446/rfmvz.v69n2.103266Keywords:
adyuvante, felino, hidróxido de aluminio, leucemia, neoplasia, virus (es)adjuvant, feline, aluminum hydroxide, leukemia, neoplasm, virus (en)
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El sarcoma felino posvacunal o sarcoma de sitio de inyección (FISS) en una neoplasia poco descrita en felinos en Colombia, se presenta posterior al uso de vacunas inactivas con adyuvante. El objetivo fue describir la presencia de un sarcoma felino posterior a la vacunación con leucemia felina virus inactivo, primer caso documentado en Colombia. Un felino, macho, mestizo, de 7 años de edad, esterilizado, vacunado con leucemia felina inactiva desde hace 3 años, desarrolla un nódulo de 5 cm de diámetro en la región dorsal, firme y no doloroso. En dermis profunda y músculo estriado, se evidencia proliferación neoplásica de células fusiformes, de crecimiento principalmente expansivo y en menor medida invasivo, que se organiza y forma haces cortos y fascículos largos que se entrecruzan, con focos densos y laxos y en focos se dispone en un patrón de espina de pescado. Las células presentan morfología fusiforme, ligeramente ovoide, irregular, algunas redondeadas, con citoplasma eosinófilo tenue e intenso en otros focos más densos. Se evidencia pleomorfismo celular y anisocitosis moderadas. Los núcleos presentan morfología redonda, ovoide e irregular. Se evidencia la presencia de uno o más nucléolos en algunas de sus células, cromatina principalmente granular fina, pleomorfismo nuclear y anisocariosis moderada. Se contabilizaron 4 mitosis en 10 campos con el objetivo de alto poder en 2,37 mm2, no se observa aparente invasión linfovascular, se evidencia compromiso de bordes laterales. Adicionalmente, discretos focos de necrosis multifocal < 50%, infiltrado inflamatorio mixto polimorfonuclear, neutrófilos moderados multifocales e infiltrado mononuclear linfocítico multifocal.
Feline postvaccinal sarcoma, or injection site sarcoma (FISS), is a poorly described neoplasm in felines in Colombia that occurs after the use of inactive vaccines with adjuvant. The objective of this report is to describe the presence of a feline sarcoma after vaccination with inactive feline leukemia virus, the first case documented in Colombia. A 7-year-old male, mestizo, sterilized feline, vaccinated with inactive feline leukemia for 3 years, develops a 5 cm diameter nodule in the dorsal region, firm and painless. In deep dermis and striated muscle, there is evidence of neoplastic proliferation of spindle cells, of mainly expansive growth and to a lesser extent invasive, organizing and forming short bundles and long bundles that intersect, with dense and lax foci and in foci it is arranged in a pattern of fishbone . The cells have a fusiform, slightly ovoid, irregular morphology, some rounded, with tenuous and intense eosinophilic cytoplasm in other denser foci. Cellular pleomorphism and moderate anisocytosis are evident. The nuclei present round, ovoid, and irregular morphology. The presence of one or more nucleoli is evidenced in some of its cells, mainly fine granular chromatin, nuclear pleomorphism and moderate anisokaryosis. 4 mitoses were recorded in 10 fields with the high-power objective of 2,37 mm2, no apparent lymphovascular invasion was observed, there was evidence of involvement of the lateral borders. Additionally, discrete multifocal necrosis foci < 50%, mixed polymorphonuclear inflammatory infiltrate with moderate multifocal neutrophils and multifocal lymphocytic mononuclear infiltrate.
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