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Peroxidación lipídica en adolescentes púberes
Lipid peroxidation in pubescent adolescents
DOI:
https://doi.org/10.15446/rsap.v20n5.63476Palabras clave:
Adolescente, peroxidación de lípido, resistencia a la insulina opinion (es)Adolescent, lipid peroxidation, insulin resistance (en)
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Objetivo Evaluar la peroxidación lipídica en adolescentes púberes con exceso de peso y la presencia o no de resistencia a la insulina.
Métodos El estudio fue descriptivo, correlacional y transversal en 80 adolescentes entre 12 y 15 años. Se determinó el perfil lipídico, LDL oxidada, 8-Isoprostano y se estimaron los índices de oxidación de LDL. Se determinó el IMC y se midió la circunferencia de cintura.
Resultados Los adolescentes con exceso de peso y resistencia a la insulina mostraron la LDL oxidada, 8-isoprostano y el índice LDL oxidada/c-HDL superior a los de quienes tenían exceso de peso sin resistencia a la insulina y que el grupo control (p<0,05).
Conclusión Los adolescentes con exceso de peso y resistencia a la insulina mostraron mayores concentraciones de marcadores de peroxidación lipídica que el resto de los adolescentes evaluados, lo que implicaría un posible papel del estrés oxidativo en el desarrollo de la resistencia a la insulina. Estos resultados ponen de manifiesto la importancia de promover una buena alimentación y estilos de vida saludables para evitar que estos adolescentes se conviertan en adultos obesos con comorbilidades asociadas a la obesidad, lo cual afectarían su calidad y tiempo de vida.
Objective To assess lipid peroxidation in pubescent adolescents with excess weight and the presence or absence of insulin resistance.
Materials and Methods This was a descriptive, correlational and cross-sectional study carried out in 80 adolescents aged between 12 and 15 years. Lipid profile, oxidized LDL, 8-Isoprostane and LDL oxidation rates were estimated. BMI was determined and waist circumference was measured.
Results Overweight and insulin resistance adolescents showed a oxidized LDL, 8-isoprostane and oxidized LDL-C/HDL ratio higher than those who were overweight without insulin resistance and that the control group (p<0.05).
Conclusion Adolescents with excess weight and insulin resistance showed higher concentrations of lipid peroxidation markers than the rest of the adolescents evaluated, which may imply a possible role of oxidative stress in the development of insulin resistance. These results highlight the importance of promoting good nutrition and healthy lifestyles to prevent these adolescents from becoming obese adults with associated comorbidities, affecting their quality of life and life expectancy.
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1. Sonia L. Ramírez-Garza, Emily P. Laveriano-Santos, Juan J. Moreno, Patricia Bodega, Amaya de Cos-Gandoy, Mercedes de Miguel, Gloria Santos-Beneit, Juan Miguel Fernández-Alvira, Rodrigo Fernández-Jiménez, Jesús Martínez-Gómez, Ana María Ruiz-León, Ramon Estruch, Rosa M. Lamuela-Raventós, Anna Tresserra-Rimbau. (2023). Metabolic syndrome, adiposity, diet, and emotional eating are associated with oxidative stress in adolescents. Frontiers in Nutrition, 10 https://doi.org/10.3389/fnut.2023.1216445.
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