THE IMPACT OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY ON LIVER FUNCTION AND ENZYMATIC ANTIOXIDANTS IN PATIENTS FROM BASRAH PROVINCE
EL IMPACTO DE LA DEFICIENCIA DE GLUCOSA-6-FOSFATO DESHIDROGENASA EN LA FUNCIÓN HEPÁTICA Y LOS ANTIOXIDANTES ENZIMÁTICOS EN PACIENTES DE LA PROVINCIA DE BASORA
DOI:
https://doi.org/10.15446/rev.fac.cienc.v14n1.117749Keywords:
Liver functions, G6PD, Antioxidants enzyme (en)Funciones hepáticas, G6PD, Enzima antioxidante (es)
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Glucose-6-phosphate dehydrogenase (G6PD) is an X-linked genetic disorder that represents the majority frequent enzymatic flaw worldwide, affecting approximately 400 million people, primarily of Asian, African and Middle Eastern descent. Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that protects red blood cells and acts as an antioxidant. In other words, it protects red blood cells from oxidative damage in cases of stress in the event of a deficiency of the enzyme G6PD; this causes the breakdown of red blood cells before they mature, and this causes what is known as hemolysis, which in turn may cause hemolytic anemia. G6PD deficiency can result in hyperbilirubinemia, hemolysis and/or jaundice in neonates, but these symptoms are typically reversible with medical intervention. The objectives of this study were an attempt to evaluate and compare some enzymatic antioxidants and biochemical parameters of liver function in patients with G6PD enzyme deficiency. This study includes 58 subjects ages 1-15 years (30) patients with glucose-6-phosphate dehydrogenase deficiency (G6PD) and (28) controls from healthy people who have normal activity of the G6PD enzyme. Samples were collected from Ibn Ghazwan Hospital in Basrah governorate from July to October 2023. The results of the study showed a significant increase in the concentration of serum AST, (P<0.01), ALT and ALP (P<0.05) in patients in G6PD deficient showed a significant increase in the concentration of serum AST (P<0.01), ALT and ALP (P<0.05) in patients in G6PD deficient group in comparison with the controls group was found a significant decrease in the activity of plasma (GPX, and SOD) in the patients' group in comparison with controls group(P<0.001 ). These results confirm that oxidative stress markers are potential new markers for the risk assessment of G6PD deficiency. The results indicated a nonsignificant positive correlation among G6PD (GPX and ALP). In contrast, a negative correlation was found among G6PD and (SOD, AST and ALT). Conclusion, Our findings are indicative of an association between abnormal G6PD levels and enzymatic antioxidants and liver functions. This indicates that the deficiency of G6PD may cause liver failure in the future.
La glucosa-6-fosfato deshidrogenasa (G6PD) es un trastorno genético ligado al cromosoma X que representa la falla enzimática más frecuente en todo el mundo, afectando aproximadamente a 400 millones de personas, principalmente de ascendencia asiática, africana y de Oriente Medio. La glucosa-6-fosfato deshidrogenasa (G6PD) es una enzima que protege a los glóbulos rojos y actúa como antioxidante. En otras palabras, protege a los glóbulos rojos del daño oxidativo en casos de estrés en caso de deficiencia de la enzima G6PD; esto provoca la degradación de los glóbulos rojos antes de que maduren, y esto causa lo que se conoce como hemólisis, que a su vez puede causar anemia hemolítica. La deficiencia de G6PD puede resultar en hiperbilirrubinemia, hemólisis y/o ictericia en neonatos, pero estos síntomas suelen ser reversibles con intervención médica. Los objetivos de este estudio fueron un intento de evaluar y comparar algunos antioxidantes enzimáticos y parámetros bioquímicos de la función hepática en pacientes con deficiencia de la enzima G6PD. Este estudio incluye 58 sujetos de entre 1 y 15 años (30) pacientes con deficiencia de glucosa-6-fosfato deshidrogenasa (G6PD) y (28) controles de personas sanas que tienen una actividad normal de la enzima G6PD. Las muestras se recogieron en el Hospital Ibn Ghazwan de la gobernación de Basora de julio a octubre de 2023. Los resultados del estudio mostraron un aumento significativo en la concentración sérica de AST (P <0,01), ALT y ALP (P <0,05) en pacientes con deficiencia de G6PD mostraron un aumento significativo en la concentración sérica de AST (P <0,01), ALT y ALP (P <0,05) en pacientes en el grupo deficiente de G6PD en comparación con el grupo de controles se encontró una disminución significativa en la actividad del plasma (GPX y SOD) en el grupo de pacientes en comparación con el grupo de controles (P <0,001). Estos resultados confirman que los marcadores de estrés oxidativo son nuevos marcadores potenciales para la evaluación del riesgo de deficiencia de G6PD. Los resultados indicaron una correlación positiva no significativa entre G6PD (GPX y ALP). En cambio, se encontró una correlación negativa entre G6PD y (SOD, AST y ALT). Conclusión: Nuestros hallazgos son indicativos de una asociación entre los niveles anormales de G6PD y los antioxidantes enzimáticos y las funciones hepáticas. Esto indica que la deficiencia de G6PD puede causar insuficiencia hepática en el futuro.
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