Publicado

2006-07-01

Ribonucleasas: su potencial terapéutico en infecciones virales

Palabras clave:

Actividad antiviral, RNasa 1, EDN, ECP, ONC. (es)

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Autores/as

  • Xiomara Úsuga Universidad de Antioquia. Medellín, Colombia. Grupo Inmunovirología•Biogénesis.
  • María Teresa Rugeles Universidad de Antioquia. Medellín, Colombia.Grupo Inmunovirología -Biogénesis

En la actualidad existe un gran interés por identificar proteínas o péptidos antimicrobianos que puedan ser herramientas terapéuticas que eviten el establecimiento o permitan el control de diferentes infecciones. Las ribonucleasas (RNasas), pertenecientes a la superfamilia Ribonucleasa A, son enzimas que participan en varios procesos fisiológicos, que van desde el procesamiento alternativo del RNA hasta la angiogénesis. Estas enzimas son expresadas por diferentes tejidos y exhiben especificidades variables contra diferentes sustratos de RNA. El potencial terapéutico de las RNasas se ha sugerido en procesos oncogénicos; adicionalmente, se ha descrito que tienen actividad antiviral directa y el potencial de activar células del sistema inmune innato induciendo su maduración y la producción de citoquinas proinflamatorias. Nuestro grupo de investigación ha realizado estudios que señalan la capacidad de cuatro RNasas recombinantes: EDN, -4EDN, RNasa A y angiogenina de inhibir la replicación del virus de la inmunodeficiencia humana tipo 1 en linfocitos T de sangre periférica activados. En este artículo se revisará la clasificación de las ribonucleasas que constituyen la superfamilia RNasa A y se describirá, en forma detallada, lo que se conoce de la función biológica, acción antiviral y mecanismo de acción de las RNasas a las que se les ha reportado actividad antiviral.

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Cómo citar

APA

Úsuga, X. y Rugeles, M. T. (2006). Ribonucleasas: su potencial terapéutico en infecciones virales. Acta Biológica Colombiana, 11(2), 31–44. https://revistas.unal.edu.co/index.php/actabiol/article/view/63300

ACM

[1]
Úsuga, X. y Rugeles, M.T. 2006. Ribonucleasas: su potencial terapéutico en infecciones virales. Acta Biológica Colombiana. 11, 2 (jul. 2006), 31–44.

ACS

(1)
Úsuga, X.; Rugeles, M. T. Ribonucleasas: su potencial terapéutico en infecciones virales. Acta biol. Colomb. 2006, 11, 31-44.

ABNT

ÚSUGA, X.; RUGELES, M. T. Ribonucleasas: su potencial terapéutico en infecciones virales. Acta Biológica Colombiana, [S. l.], v. 11, n. 2, p. 31–44, 2006. Disponível em: https://revistas.unal.edu.co/index.php/actabiol/article/view/63300. Acesso em: 29 mar. 2024.

Chicago

Úsuga, Xiomara, y María Teresa Rugeles. 2006. «Ribonucleasas: su potencial terapéutico en infecciones virales». Acta Biológica Colombiana 11 (2):31-44. https://revistas.unal.edu.co/index.php/actabiol/article/view/63300.

Harvard

Úsuga, X. y Rugeles, M. T. (2006) «Ribonucleasas: su potencial terapéutico en infecciones virales», Acta Biológica Colombiana, 11(2), pp. 31–44. Disponible en: https://revistas.unal.edu.co/index.php/actabiol/article/view/63300 (Accedido: 29 marzo 2024).

IEEE

[1]
X. Úsuga y M. T. Rugeles, «Ribonucleasas: su potencial terapéutico en infecciones virales», Acta biol. Colomb., vol. 11, n.º 2, pp. 31–44, jul. 2006.

MLA

Úsuga, X., y M. T. Rugeles. «Ribonucleasas: su potencial terapéutico en infecciones virales». Acta Biológica Colombiana, vol. 11, n.º 2, julio de 2006, pp. 31-44, https://revistas.unal.edu.co/index.php/actabiol/article/view/63300.

Turabian

Úsuga, Xiomara, y María Teresa Rugeles. «Ribonucleasas: su potencial terapéutico en infecciones virales». Acta Biológica Colombiana 11, no. 2 (julio 1, 2006): 31–44. Accedido marzo 29, 2024. https://revistas.unal.edu.co/index.php/actabiol/article/view/63300.

Vancouver

1.
Úsuga X, Rugeles MT. Ribonucleasas: su potencial terapéutico en infecciones virales. Acta biol. Colomb. [Internet]. 1 de julio de 2006 [citado 29 de marzo de 2024];11(2):31-44. Disponible en: https://revistas.unal.edu.co/index.php/actabiol/article/view/63300

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