Publicado

2020-07-01

Porphyromonas gingivalis ligada a enfermedad periodontal y su relación con la artritis reumatoide: identificación de nuevos mecanismos biomoleculares

Porphyromonas gingivalis linked to periodontal disease and its relationship with rheumatoid arthritis: Identification of new biomolecular mechanisms

DOI:

https://doi.org/10.15446/aoc.v10n2.85185

Palabras clave:

Aggregatibacter actinomycetemcomitans, artritis reumatoide, citrulinación, disbiosis, odontología, periodontitis, Porphyromonas gingivalis, reumatología (es)
Aggregatibacter actinomycetemcomitans, rheumatoid arthritis, citrullination, dysbiosis, dentistry, periodontitis, porphyromonas gingivalis, rheumatology. (en)

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Objetivo: revisar la literatura científica existente con respecto a la patogenicidad de Porphyromonas gingivalis, ligada a enfermedad periodontal (EP) (disbiosis oral), y su asociación con la activación de mecanismos fisiopatológicos en la artritis reumatoide (AR), a fin de exponer los nuevos mecanismos biomoleculares implicados. Métodos: búsqueda sistemática en la base de datos del Medical Subject Headings (MeSH), PubMed, Science Direct, Nature y Google académico usando las palabras clave: Aggregatibacter actinomycetemcomitans; artritis reumatoide; citrulinación; disbiosis; odontología; periodontitis; Porphyromonas gingivalis y reumatología. De un total de 297 publicaciones, se seleccionaron 52, todas a partir del año 2018; la selección fue hecha a partir de los criterios de inclusión y exclusión establecidos por los autores. Resultados: la infección por Porphyromonas gingivalis, ligada a la EP, está fuertemente implicada en la patogénesis y desarrollo de AR. Su relación se vincula con el proceso de citrulinación y producción de anticuerpos antipéptidos citrulinados. Se han identificado asociaciones entre la virulencia microbiana de dicho agente y la expresión de múltiples genes, relacionados con la activación de la respuesta inmune y el inicio del proceso inflamatorio crónico. Conclusiones: existe una alta asociación entre la patogenia de ambas enfermedades, donde microorganismos ligados a la EP, como Porphyromonas gingivalis, tienen la capacidad de aumentar la citrulinación, galactosilación, fucosilación, así como la excesiva glicosilación de Fragmentos de unión al antígeno (Fab), y por lo tanto, la agresividad de la AR.

Objective: Review the existing scientific literature regarding the pathogenicity of Porphyromonas gingivalis, linked to periodontal disease (PD) (oral dysbiosis), and its association with the activation of pathophysiological mechanisms of rheumatoid arthritis (RA), in order to expose the new mechanisms biomolecular involved. Methods: Systematic search in the MeSH, pubmed, Science Direct, Nature y Google academic database, using the keywords: Aggregatibacter actinomycetemcomitans; rheumatoid arthritis; citrullination; dysbiosis; dentistry; periodontitis; porphyromonas gingivalis; rheumatology. Out of a total of 297 publications, 52 were selected, all from 2018; based on the inclusion and exclusion criteria established by the authors. Results: Pg infection linked to periodontal disease is strongly implicated in the pathogenesis and development of RA. Their relationship is linked to the citrullination process and production of citrullinated antipeptide antibodies. Associations have been identified between the microbial virulence of this agent and the expression of multiple genes related to the activation of the immune response and the onset of the chronic inflammatory process. Conclusions: There is a high association between the pathogenesis of both diseases, where microorganisms linked to PD such as Pg have the ability to increase citrullination, galactosylation, fucosylation, as well as excessive glycosylation of fragments antigen-binding (Fab), and therefore the aggressiveness of RA.

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