Publicado

2016-01-01

Tratamiento de cáncer de seno y farmacogenética

Treatment of breast cancer and pharmacogenetics

Palabras clave:

cáncer de seno, farmacocinética, tamoxifeno, hormonoterapia (es)

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Autores/as

  • Yeimy Viviana Ariza Márquez Universidad Nacional de Colombia, Sede Bogotá.
  • Ignacio Briceño Balcázar Universidad de la Sabana y Pontificia Universidad Javeriana
  • Fabio Ancízar Aristizábal Director Instituto de Biotecnología Universidad Nacional de Colombia, Sede Bogotá
El cáncer de seno es una enfermedad con gran impacto a nivel mundial dado que es una de las patologías con mayor prevalencia en mujeres y el cáncer con mayor tasa de mortalidad en varios países (GLOBOCAN 2012). El uso de la farmacogenética y farmacogenómica, en pacientes con cáncer de seno tiene como fin, generar una salud personalizada que permita tratar a cada paciente como individuo y no como enfermedad, pues cada paciente tiene necesidades particulares a la hora de suministrarle un tratamiento. El propósito  de esta revisión es identificar las variantes genéticas reportadas en la literatura científica, donde se evalúan diferentes poblaciones y su posible uso como herramienta para medicina de precisión. En población colombiana es poca la caracterización poblacional que existe y por tanto estudios poblacionales son necesarios para definir los perfiles genéticos que deberán implementarse en nuestra población.

Breast cancer is one of the most prevalent diseases in women with increasing mortality in several countries (GLOBOCAN 2012). The use of pharmacogenetics and pharmacogenomics in patients with breast cancer allows generating personalized health for treating each patient as an individual, as each patient has unique needs when supplying a treatment. The purpose of this review is to identify genetic variants reported in the scientific literature, where different populations are evaluated and for possible use as a tool for medical precision.Colombian population is unique and therefore population studies are needed to define the genetic profiles to be implemented.

Key words: breast cancer, pharmacokinetic, tamoxifen, hormone therapy.

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