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Synthesis and evaluation of the antibacterial activity of Cu(II) and Ni(II) complexes with mixed ligands based on glycine and dicarboxylic acids
Síntesis y evaluación de la actividad antibacteriana de complejos de Cu(II) y Ni(II) con ligandos mixtos basados en glicina y ácidos dicarboxílicos
DOI:
https://doi.org/10.15446/dyna.v91n234.112116Palabras clave:
complexes, amino acids, glycine, itaconic acid, oxalic acid (en)complejos, aminoácidos, glicina, ácido itacónico, ácido oxálico (es)
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A large number of metal complexes have the ability to inhibit bacterial growth. Cu(II) and Ni(II) complexes based on glycine (Gly), itaconic acid (Ita), and oxalic acid (Ox) were synthesized by conventional methods and evaluated for their antibacterial activity. The metal complexes were characterized by TGA, FTIR, UV-vis spectroscopy, and XRD. The metal: ligands (M:L1:L2) stoichiometry of these complexes is 1:2:2, and coordination around Cu(II) and Ni(II) seems to be octahedral, with the ligands bound through the N atom of the amino group and O atoms of the bridging carboxylate group. These compounds are crystalline and stable at temperatures between 250 to 300°C. The metal complexes were screened for their antibacterial activity against the bacterial species Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Salmonella, and Escherichia coli. These compounds were shown to have antibacterial activity mainly against gram-positive strains, with a minimum inhibitory concentration of 20 ppm.
Un gran número de complejos metálicos tienen la capacidad de inhibir el crecimiento bacteriano. Se sintetizaron complejos de Cu(II) y Ni(II) basados en glicina (Gly), ácido itacónico (Ita) y ácido oxálico (Ox) mediante métodos convencionales y se evaluó su actividad antibacteriana. Los complejos metálicos se caracterizaron por TGA, FTIR, espectroscopia UV-vis y XRD. La estequiometría metal:ligandos (M:L1:L2) de estos complejos es 1:2:2, y la coordinación alrededor de Cu(II) y Ni(II) parece ser octaédrica, con los ligandos unidos a través del átomo de N del grupo amino y los átomos de O del grupo carboxilato puente. Estos compuestos son cristalinos y estables a temperaturas entre 250 y 300°C. Los complejos metálicos se probaron para su actividad antibacteriana contra las especies bacterianas Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Salmonella y Escherichia coli. Estos compuestos demostraron tener actividad antibacteriana principalmente contra cepas gram-positivas, con una concentración mínima inhibitoria de 20 ppm.
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