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Analysis of the contribution of PDMS biomaterials in their application to lung organ-on-chip systems: a systematic review
Análisis de la contribución de los biomateriales PDMS en su aplicación a órganos en chip pulmonares: revisión sistemática
DOI:
https://doi.org/10.15446/dyna.v93n242.124838Palabras clave:
pulmonary diseases, biomaterials, organ-on-chip, polydimethylsiloxane, microfluidic devices (en)enfermedades pulmonares, biomateriales, órganos en chip, polidimetilsiloxano, dispositivos microfluídicos (es)
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Pulmonary diseases affect both lung tissue and its physiological function. In most cases, available treatments focus primarily on symptomatic management, underscoring the need for innovative therapeutic and modeling strategies. This study presents a rigorous systematic review, employing multiple search equations across various databases, to examine the use of biomaterials in the development of organ-on-chip platforms as potential tools for modeling and treating pulmonary diseases. The properties of polydimethylsiloxane (PDMS) and silicone elastomers are evaluated, with emphasis on their biocompatibility and suitability for microfluidic device fabrication. Finally, an experimental design is proposed to assess the feasibility of these biomaterials in an organ-on-chip model for pulmonary disease research.
Las enfermedades pulmonares comprometen su tejido y su función normal. En la mayoría de los casos los tratamientos son de control sintomático, lo que resalta la necesidad de enfoques innovadores. En este estudio, se presenta una revisión sistemática rigurosa, con diferentes ecuaciones de búsqueda utilizadas en varias bases de datos, sobre el uso de biomateriales para el desarrollo de órganos en chip como posibles herramientas en el modelado y tratamiento de enfermedades pulmonares. Se analizan las propiedades del polidimetilsiloxano (PDMS) y elastómeros de silicona, destacando su biocompatibilidad y aplicabilidad en dispositivos microfluídicos. Finalmente, se plantea un diseño experimental para validar la viabilidad de estos biomateriales en un modelo de órgano en chip para enfermedades pulmonares.
Referencias
[1] Soriano, J.B., et al., Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet Respiratory Medicine, 5(9), pp. 691–706, 2017. DOI: https://doi.org/10.1016/S2213-2600(17)30293-X
[2] Ranga, A., et al., Drug discovery through stem cell-based organoid models. Advanced Drug Delivery Reviews, 69–70, pp. 19–28, 2014. DOI: https://doi.org/10.1016/j.addr.2014.02.006
[3] Bhatia, S.N., et al., Microfluidic organs-on-chips. Nature Biotechnology, 32(8), pp. 760–772, 2014. DOI: https://doi.org/10.1038/NBT.2989;SUBJMETA
[4] Danku, A., et al., Organ-On-A-Chip: a survey of technical results and problems. Frontiers in Bioengineering and Biotechnology, 10, art. 840674, 2022. DOI: https://doi.org/10.3389/FBIOE.2022.840674
[5] Huh, D., et al, A human breathing lung-on-a-chip. Annals of the American Thoracic Society, 12(1), pp. 42–44, 2015. DOI: https://doi.org/10.1513/ANNALSATS.201410-442MG
[6] Zhang, Y.S., et al., Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors. Proceedings of the National Academy of Sciences of the United States of America, 114(12), pp. 2293–2302, 2017. DOI: https://doi.org/10.1073/PNAS.1612906114
[7] Hassell, B.A., et al., Human organ chip models recapitulate orthotopic lung cancer growth, therapeutic responses, and tumor dormancy in vitro. Cell Reports, 21(2), pp. 508–516, 2017. DOI: https://doi.org/10.1016/j.celrep.2017.09.043
[8] Van-Meer, B.J., et al., Small molecule absorption by PDMS in the context of drug response bioassays. Biochemical and Biophysical Research Communications, 482(2), pp. 323–328, 2017. DOI: https://doi.org/10.1016/j.bbrc.2016.11.062
[9] Wang, L., et al., Different in vitro cellular responses to tamoxifen treatment in polydimethylsiloxane-based devices compared to normal cell culture. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1068–1069, pp. 105–111, 2017. DOI: https://doi.org/10.1016/j.jchromb.2017.09.041
[10] Zhang, B., et al., Advances in organ-on-a-chip engineering. Nature Reviews Materials, 3(8), pp. 257–278, 2018. DOI: https://doi.org/10.1038/S41578-018-0034-7;SUBJMETA
[11] Bhise, N.S., et al., A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication, 8(1), art. 14101, 2016. DOI: https://doi.org/10.1088/1758-5090/8/1/014101
[12] Park, S.E., et al., Organoids-on-a-chip. Science (New York, N.Y.), 364(6444), pp. 960–965, 2019. DOI: https://doi.org/10.1126/SCIENCE.AAW7894
[13] World Health Organization: WHO, The top 10 causes of death [online]. 2024. Available at: https://www.who.int/es/news-room/fact-sheets/detail/the-top-10-causes-of-death
[14] Castillo, E.G., et al., Enfermedad pulmonar obstructiva crónica. Open Respiratory Archives, 4(2), art. 100171, 2022. DOI: https://doi.org/10.1016/j.opresp.2022.100171
[15] Halldorsson, S., et al., Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices. Biosens Bioelectron, 63, pp. 218-231, 2015. DOI: http://doi.org/10.1016/j.bios.2014.07.029
[16] Gomez-Sjoberg, R., et al, Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications. Analytical Chemistry, 82(21), pp. 8954–8960, 2010. DOI: https://doi.org/10.1021/ac101870s
[17] Liu, L., et al., A micro-channel-well system for culture and differentiation of embryonic stem cells on different types of substrate. Biomedical Microdevices, 12(3), pp. 505–511, 2010. DOI: https://doi.org/10.1007/s10544-010-9407-4
[18] Lavielle, N., et al., Lubrication dynamics of swollen silicones to limit long term fouling and microbial biofilms. Soft Matter, 17(4), pp. 936–946, 2021. DOI: https://doi.org/10.1039/d0sm01039a
[19] Chuah, Y.J., et al., Simple surface engineering of polydimethylsiloxane with polydopamine for stabilized mesenchymal stem cell adhesion and multipotency. Scientific Reports, 5, art. 181162, 2015. DOI: https://doi.org/10.1038/srep18162
[20] Sotiri, I., et al., Tunability of liquid-infused silicone materials for biointerfaces. Biointerphases, 13(6), art. 9514, 2018. DOI:https://doi.org/10.1116/1.5039514
[21] Kolle, S., et al., On the mechanism of marine fouling-prevention performance of oil-containing silicone elastomers. Scientific Reports, 12(1), art. 11719, 2022. DOI: https://doi.org/10.1038/s41598-022-15553-4
[22] Park, S.J., et al., Visualization of asymmetric wetting ridges on soft solids with X-ray microscopy. Nature Communications, 5, art. 5369, 2014. DOI: https://doi.org/10.1038/ncomms5369
[23] Camacho-Ramírez, A., and Guerra-Contreras, A., Curcumina: propiedades, aplicaciones y estudios recientes con sistemas basados en polidimetilsiloxano. ISSN: 2007-672X, 2020.
[24] Huh, D., et al., Reconstituting organ-level lung functions on a chip. Science, 328(5986), pp. 1662-1668, 2010. DOI: https://doi.org/10.1126/science.1188302
[25] Dardouri, M., et al., Bonding antimicrobial rhamnolipids onto medical grade PDMS: A strategy to overcome multispecies vascular catheter-related infections. Colloids and Surfaces B: biointerfaces, 217, art. 112679, 2022. DOI: https://doi.org/10.1016/j.colsurfb.2022.112679
[26] Khan, K.A., et al., A variational constitutive framework for the nonlinear viscoelastic response of a dielectric elastomer. Computational Mechanics, 52(2), pp. 345–360, 2013. DOI: https://doi.org/10.1007/s00466-012-0815-6
[27] De-Elastómeros, C., Varón, D.J., Gimeno, R.B., Ferrándiz-Bou, S., and Sanoguera, D.G., Estudio, análisis y “study, analisys and classification of thermoplastic elastomers, 2012.
[28] Kumar, D., et al., Advances and challenges in organ-on-chip technology: toward mimicking human physiology and disease in vitro. Med Biol Eng Comput, 62(7), pp. 1925-1957, 2024. DOI: https://doi.org/10.1007/s11517- 024-03062-7
[29] Sadeghzade, S., et al., Highly stretchable alginate/methylcellulose hydrogels for 3D bio-printing: photopolymerization approach enhancing structural integrity. Giant, 18., art. 100280, 2024. DOI: https://doi.org/10.1016/j.giant.2024.100280
[30] Hassan, S., et al., Biomaterials for on-chip organ systems. In biomaterials for organ and tissue regeneration: new technologies and future prospects. Elsevier, pp. 669–707, art. 2, 2020. DOI: https://doi.org/10.1016/B978-0-08- 102906-0.00019-2
[31] Gonçalves, I.M., et al., Recent trends of biomaterials and biosensors for organ-on-chip platforms. In Bioprinting Elsevier B.V., 26, 2022. DOI: https://doi.org/10.1016/j.bprint.2022.e00202
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