Published

2017-10-01

Carbon nanotube dispersion for in-vitro applications

Dispersión de nanotubos de carbono para aplicaciones in-vitro

DOI:

https://doi.org/10.15446/dyna.v84n203.64132

Keywords:

Carbon Nanotube, Dispersion, Ultrasound (en)
Nanotubos de Carbono, Dispersión, Ultrasonido (es)

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Carbon nanotubes (CNTs) have gained popularity due to their many characteristics which make them the promising material for biomedical applications. A major challenge when working with CNTs is the difficulty to distribute them evenly throughout liquids. This research is a comparative analysis of the dispersion of multi wall CNTs (MWCNTs) in different liquid media (distilled water, ultrapure water of type I [Milli-Q], ethanol, dimethyl sulfoxide [DMSO] and cell culture medium [RPMI-1640]) by using two different sonication techniques (probe-type sonication and ultrasonic bath sonication) as well as determining the effect of sterilization in the presence and absence of fluid before dispersion. The results indicate that the best method to achieve a CNTs dispersion is to use a probe-type sonicator as well as to sterilize the CNTs samples in the presence of fluid.
Los nanotubos de carbono (CNTs) han atraído un enorme interés debido a sus muchas características que los convierten en un material prometedor para aplicaciones biomedicas. Un desafío importante cuando se trabaja con CNTs es la dificultad de dispersarlos homogéneamente en un fluido. Esta investigación es un análisis comparativo de la dispersión de nanotubos de carbono de pared múltiple (MWCNTs) en diferentes fluidos (agua destilada, agua ultrapura de tipo I [Milli-Q], etanol, dimetilsulfóxido [DMSO] y medio de cultivo celular [RPMI-1640]). Utilizando dos diferentes técnicas de sonicación (sonicación con lanza ultrasónica y sonicación ultrasónica de baño), así como la determinación del efecto de la esterilización en presencia y ausencia de fluido antes de la dispersión. Los resultados indican que el mejor método de dispersión de los CNTs es usando un sonicador tipo lanza y esterilizarlos en presencia de fluido.

References

Iijima, S., Helical microtubules of graphitic carbon. Nature, 354(6348), pp. 56-58, 1991. DOI: 10.1038/354056a0

Ema, M., Imamura, T., Suzuki, H., Kobayashi, N., Naya, M. and Nakanishi, J., Evaluation of genotoxicity of multi-walled carbon nanotubes in a battery of in vitro and in vivo assays. Regulatory Toxicology and Pharmacology, 63(2), pp. 188-195, 2012. DOI: 0.1016/j.yrtph.2012.03.014

Stern, S.T. and McNeil, S.E., Nanotechnology safety concerns revisited. Toxicological Sciences, 101(1), pp. 4-21, 2008. DOI: 10.1093/toxsci/kfm169

Yang, Y., Grulke, E.A., Zhang, Z.G. and Wu, G., Temperature effects on the rheological properties of carbon nanotube-in-oil dispersions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 298(3), pp. 216-224, 2007. DOI:10.1016/j.colsurfa.2006.10.065

Carlos-Cornelio, J.A., Cuervo-Velásquez, P.A., Ardila, M.I., Orozco-Murillo, O.M., Jaramillo-Zuluaga, L.F., Hoyos-Palacio, L.M., Lara-Romero, J. y Toro, A., Propiedades reológicas de nanotubos de carbono como aditivo en un fluido lubricante DYNA, 83(199), pp. 229-236, 2016. DOI: 10.15446/dyna.v83n199.54900

Dhawan, A. and Sharma, V., Toxicity assessment of nanomaterials: Methods and challenges. Analytical and Bioanalytical Chemistry, 398(2), pp. 589-605, 2010. DOI: 10.1007/s00216-010-3996-x

Koh, B.E., Dispersion of Single-Walled Carbon Nanotubes (SWCNTs) in aqueous solution and reversion of SWCNT aggregates. University of Michigan, 2013. [On line]. Available in: https://deepblue.lib.umich.edu/bitstream/handle/2027.42/102316/ericlo_1.pdf?sequence=1&isAllowed=y

Jiang, L., Gao, L. and Sun, J., Production of aqueous colloidal dispersions of carbon nanotubes. Journal of Colloid and Interface Science, 260(1), pp. 89-94, 2003. DOI:10.1016/S0021-9797(02)00176-5

Monteiro-Riviere, N.A., Inman, A.O., Wang, Y.Y. and Nemanich, R.J., Surfactant effects on carbon nanotube interactions with human keratinocytes. Nanomedicine: Nanotechnology, Biology and Medicine, 1(4), pp. 293-299, 2005. DOI: 10.1016/j.nano.2005.10.007

Rastogi, R., Kaushal, R., Tripathi, S.K., Sharma, A.L., Kaur, I. and Bharadwaj, L.M., Comparative study of carbon nanotube dispersion using surfactants. Journal of Colloid and Interface Science, 328(2), pp. 421-428, 2008. DOI: 10.1016/j.jcis.2008.09.015

Sager, T.M., Porter, D.W., Robinson, V.A., Lindsley, W.G.,

Schwegler-Berry, D.E. and Castranova, V., Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity. Nanotoxicology, 1(2), pp. 118-129, 2007. DOI: 10.1080/17435390701381596

Vaisman, L., Wagner, H.D. and Marom, G., The role of surfactants in dispersion of carbon nanotubes. Advances in colloid and interface science, 128, pp. 37-46, 2006. DOI: 10.1016/j.cis.2006.11.007

Arora, S., Rajwade, J.M. and Paknikar, K.M., Nanotoxicology and in vitro studies: The need of the hour. Toxicology and applied pharmacology, 258(2), pp. 151-165, 2012. DOI: 10.1016/j.taap.2011.11.010

Yanamala, N., Kagan, V.E. and Shvedova, A.A. Molecular modeling in structural nano-toxicology: Interactions of nano-particles with nano-machinery of cells. Advanced drug delivery reviews, 65(15), pp. 2070-2077, 2013. DOI: 10.1016/j.addr.2013.05.005

Du, J., Wang, S., You, H. and Zhao, X., Understanding the toxicity of carbon nanotubes in the environment is crucial to the control of nanomaterials in producing and processing and the assessment of health risk for human: A review. Environmental Toxicology and Pharmacology, 36(2), pp. 451-462, 2013. DOI: 10.1016/j.etap.2013.05.007

Zhao, X. and Liu, R., Recent progress and perspectives on the toxicity of carbon nanotubes at organism, organ, cell, and biomacromolecule levels. Environment International, 40, pp. 244-255, 2012. DOI: 10.1016/j.envint.2011.12.003

Madani, S.Y., Mandel, A. and Seifalian, A.M., A concise review of carbon nanotube’s toxicology. Nano Reviews & Experiments, 4, 2013. DOI: 10.3402/nano.v4i0.21521

Hoyos-Palacio, L.M., Efecto de los catalizadores hierro, cobalto, níquel, molibdeno, y mezclas soportadas sobre sílice sol gel, para la síntesis de nanotubos de carbono mediante deposición química de vapor, Tesis de Doctorado en Ingeniería. Universidad Pontificia Bolivariana, Medellín, Colombia 2010, 204 P.

Hilding, J., Grulke, E.A., George-Zhang, Z. and Lockwood, F., Dispersion of carbon nanotubes in liquids. Journal of Dispersion Science and Technology, 24(1), pp. 1-41, 2003. DOI: 10.1081/DIS-120017941

López, J., Síntesis de nanopartículas metálicas de Ce y Zr soportadas sobre nanotubos de carbono y su aplicación en la adsorción de colorantes sintéticos. Tesis Dr. en Ingeniería Química. Universidad Michoacana de San Nicolás de Hidalgo, Michoacán, México, 2014, 135 P.

Murdock, R.C., Braydich-Stolle, L., Schrand, A.M., Schlager, J.J. and Hussain, S.M., Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique. Toxicological Sciences, 101(2), pp. 239-253, 2008. DOI: 10.1093/toxsci/kfm240

Ruan, B. and Jacobi, A.M., Ultrasonication effects on thermal and rheological properties of carbon nanotube suspensions. Nanoscale Research Letters, 7(127), 2012. DOI: 10.1186/1556-276X-7-127

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How to Cite

[1]
C. Espinosa, I. C. Ortiz-Trujillo, J. A. Carlos-Cornelio, R. D. Zapata-Hernández, and L. M. Hoyos-Palacio, “Carbon nanotube dispersion for in-vitro applications”, DYNA, vol. 84, no. 203, pp. 24–30, Oct. 2017, doi: 10.15446/dyna.v84n203.64132.

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