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Teratogenic effect on bone tissue development in Rattus norvegicus Wistar strain, induced by the presence of arsenic
Efecto teratogénico sobre el desarrollo del tejido óseo en la cepa Wistar de Rattus norvegicus, inducida por la presencia de arsénico
DOI:
https://doi.org/10.15446/dyna.v85n206.68670Palabras clave:
sodium arsenate, teratogenic, reproductive harm, lack of ossification, Rattus norvegicus (en)arseniato de sodio, teratogénico, daño reproductive, falta de osificación, Rattus norvegicus (es)
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In this study we evaluated the possible teratogenic effects of arsenic (As) in the same concentrations recorded in water Zimapan, Hidalgo, using specimens of Rattus norvegicus Wistar strain, pregnant. Were subjected to varying concentrations of sodium arsenate (1887.9 mg/L, 943.9 mg/L and 0.5 mg/L), concentration, 0.5 mg/L corresponds to the registered Zimapan water, Hidalgo and chromium trioxide (166.0 mg/L) used as positive control and 5% sucrose as a negative control. The specimens were exposed from day 7 through 15 of gestation, and were sacrificed on day 19 of gestation by inhalation of chloroform. We analyzed reproductive harm the mother, as well as alterations and lack of ossification of the bone tissue of the fetus. The highest dose tested (1887.9 mg/L) produced more reproductive harm in mother resorptions caused by preventing the continuation of embryonic development. Concentrations of 0.5 mg/L to 943.9 mg/L, resulted in lack of ossification ribs, sternebrae, metacarpals, phalanges previous metatarsals and phalanges posterior sacral vertebrae.
En este estudio evaluamos los posibles efectos teratogénicos del arsénico (As) en las mismas concentraciones registradas en el agua de Zimapan, Hidalgo, usando especímenes de la cepa Wist de Rattus norvegicus, preñada. Se sometieron a concentraciones variables de arseniato de sodio (1887.9 mg/L, 943.9 mg/L y 0.5 mg/L), concentración, 0.5 mg/L corresponde al agua registrada de Zimapan, Hidalgo y trióxido de cromo (166.0 mg/L) utilizados como control positivo y 5% de sacarosa como control negativo. Las muestras se expusieron del día 7 al 15 de gestación y se sacrificaron el día 19 de gestación por inhalación de cloroformo. Analizamos el daño reproductivo de la madre, así como las alteraciones y la falta de osificación del tejido óseo del feto. La dosis más alta probada (1887.9 mg/L) produjo más daño reproductivo en las resorciones de la madre causado por la prevención de la continuación del desarrollo embrionario. Concentraciones de 0.5 mg/L a 943.9 mg/L, resultaron en la falta de costillas de osificación, esternebras, metacarpianos, falanges metatarsales previos y falanges de vértebras sacras posteriores.
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