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Dosimetry of radiopharmaceuticals used in adult patients with suspected pulmonary embolism
Dosimetría de radiofarmacos utilizados en pacientes adultos con sospecha de embolia pulmonar
DOI:
https://doi.org/10.15446/mo.n63.95617Keywords:
Internal dosimetry, radiopharmaceuticals, ventilation, pulmonary embolism (en)Dosimetría interna, radiofármacos, ventilación, embolia pulmonar (es)
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The absorbed dose of radiopharmaceuticals is estimated in adults with suspected pulmonary embolism explored by ventilation/perfusion studies. For pulmonary ventilation studies 81mKr, 133Xe, 99mTc (Technegas)-aerosol and 99mTc (DTPA)-aerosol are used. For perfusion agents, 99mTc(MAA), 99mTc (MSA) (macroaggregates and albumin microspheres) are used. For the dose calculation, the MIRD methodology and the anthropomorphic representation of the biokinetic organs of Cristy-Eckerman are used. In ventilation/perfusion studies, the lowest dose absorbed by the lungs with suspected embolism is due to 81mKr/ 99mTc (MSA), and the highest dose is due to 99mTc (Technegas)/99mTc (MAA) calculated for activities of 150 MBq for perfusion agents and 40 MBq for ventilation agents.
Se estima la dosis absorbida de radiofarmacos en adultos con sospecha de embolia pulmonar explorada por estudios de ventilación/perfusión Para estudios de ventilación pulmonar se utilizan 81mKr, 133Xe, 99mTc(Technegas) -aerosol y 99mTc (DTPA) - aerosol. Para agentes de perfusión se utilizan 99mTc (MAA), y 99mTc(MSA) (macroagregados y microesferas de albumina). Para el cálculo de dosis se utiliza la metodología MIRD y la
representación antropomórfica de los órganos biocinéticos de Cristy-Eckerman.
En estudios de ventilación/perfusion la menor dosis absorbida por los pulmones con sospecha de embolia se debe a 81mKr/ 99mTc (MSA), y la dosis más alta se debe a 99mTc(Technegas)/99mTc(MAA), calculada para actividades de 150 MBq para agentes de perfusión y 40 MBq para agentes de ventilación.
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