Published

2022-07-18

Lesions in the Ventromedial Prefrontal Cortex and their Impact on Social Cognition

Lesiones en la Corteza Prefrontal Ventromedial y su Impacto en la Cognición Social

DOI:

https://doi.org/10.15446/rcp.v31n2.88206

Keywords:

Ventromedial, stroke, social cognition, Theory of mind, empathy. (en)
Ventromedial, ACV, cognición social, Teoría de la mente, empatía. (es)

Downloads

Authors

Aims: To identify the impact of ventromedial prefrontal cortex injury (vmPFC) on social cognition (SC) processes in a stroke patient in relation to a control group matched by age, gender and schooling. Possible associations between post-injury behavior and impacted neuropsychological attributes of emotion recognition, Theory of Mind (ToM), and empathy are discussed. Method: A patient with stroke in right vmPFC and 10 healthy participants completed different screening, neuropsychological assessment and SC tests. Results: Correlations were found between damage in vmPFC and alterations in affective ToM, working and retrograde memory, mood and relational alterations in the patient. Discrepancies were found with respect to other studies in relation to the laterality of the injury and the impact of cognitive and affective empathy which seems to be relatively intact. Conclusions: There is a need to clarify the role of affective ToM after acquired brain injury (ABI) in vmPFC. A protocol is needed to assess and intervene in aspects of ToM that would involve documenting strengths and deficits of ToM: inter and intrapersonal after an ABI. Similarly, there is a need to address the lateralization of different domains of function in vmPFC and their relationship to affective ToM.

 

How to cite: Sánchez Tombe, J. R. (2022). Lesions In The Ventromedial Prefrontal Cortex And Their Impact On Social Cognition. Revista Colombiana de  Psicología,31(2), 11-26. https://doi.org/10.15446/rcp.
v31n2.88206

Objetivo: Identificar el impacto de la lesión en la corteza prefrontal ventromedial (vmPFC por sus siglas en inglés) en los procesos de cognición social (SC por sus siglas en inglés) a un paciente con accidente cerebrovascular (ACV) en relación a un grupo control pareado por edad, género y escolaridad. Se discuten las posibles asociaciones entre el comportamiento posterior a la lesión y los atributos neuropsicológicos impactados de reconocimiento de emociones, Teoría de la Mente (ToM por sus siglas en inglés) y empatía. Método: Un paciente con ACV en el vmPFC derecho y 10 participantes sanos completaron diferentes pruebas de screening, evaluación neuropsicológica y SC. Resultados: Se encontraron correlaciones entre el daño en vmPFC y alteraciones en la ToM afectiva, memoria de trabajo y retrógrada, alteraciones anímicas y relacionales en el paciente. Se hallaron discrepancias frente a otros estudios en relación con la lateralidad de la lesión y al impacto de la empatía cognitiva y afectiva la cual parece estar relativamente intacta. Conclusiones: Se requiere aclarar el panorama frente al deterioro de la ToM afectiva después de una lesión cerebral adquirida (ABI por sus siglas en inglés) en vmPFC. Se necesita un protocolo para evaluar e intervenir en aspectos de la ToM que involucraría documentar fortalezas y déficits de ToM: inter e intrapersonal después de un ABI. De igual manera, se requiere abordar la lateralización de diferentes dominios de la función en vmPFC y su relación con la ToM afectiva.

 

Cómo citar este artículo: Sánchez Tombe, J. R. (2022). Lesions In The Ventromedial Prefrontal Cortex And Their Impact On Social Cognition. Revista Colombiana de  Psicología,31(2), 11-26. https://doi.org/10.15446/rcp.
v31n2.88206

References

Baez, S., Marengo, J., Perez, A., Huepe, D., Giralt, F., Rial, V., y otros. (2014). Theory of mind and its relationship with executive functions and emotion recognition in borderline personality disorder. The British Psychological Society, 1-16. DOI: https://doi.org/10.1111/jnp.12046

Baron-Cohen S, Leslie AM, Frith U. (1985). Does the autistic child have a ‘‘theory of mind’’? Cognition. 1985; 21:37–46. DOI: https://doi.org/10.1016/0010-0277(85)90022-8

Baron-Cohen S, Ring H, Moriarty J, et al. (1994). Recognition of mental state terms. Clinical findings in children with autism and a functional neuroimaging study of normal adults. Br J Psychiatry. 1994; 165:640–649. DOI: https://doi.org/10.1192/bjp.165.5.640

Baron-Cohen S, O’Riordan M, Stone V, et al. (1999). Recognition of faux pas by normally developing children and children with Asperger syndrome or high-functioning autism. J Autism Dev Disord. 1999; 29:407–418.

Beckler, K. (2010). State-Trait Anxiety Inventory for Adults. Obtenido de Mind Garden,: https://www.essex.ac.uk/-/media/elct/zhao---anxiety-inventory.pdf?la=en

Bechara, A., Damasio, A.R., (2005). The somatic marker hypothesis: a neural theory of economic decision. Games Econ. Behav. 52, 336–372. DOI: https://doi.org/10.1016/j.geb.2004.06.010

Contreras, D., Catena, A., Cándido, A., Perales, J., & Maldonado, A. (2008). Funciones de la corteza prefrontal ventromedial en la toma de decisiones emocionales. International Journal of Clinical and Health Psychology, 285-313

Couto, B., Sedeño, L., Sposato, L. A., Sigman, M., Riccio, P. M., Salles, A.,… Ibanez, A. (2012). Clinical neuroanatomy Insular networks for emotional processing and social cognition: Comparison of two case reports with either cortical or subcortical involvement. CORTEX. https://doi.org/10.1016/j.cortex.2012.08.006 DOI: https://doi.org/10.1016/j.cortex.2012.08.006

Damasio AR, Tranel D, Damasio H. (1990). Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behav Brain Res. 1990; 41:81–94. DOI: https://doi.org/10.1016/0166-4328(90)90144-4

Dimitrov, M., Phipps, M., Zahn, T.P. y Grafman, J. (1999). A thoroughly modern Gage. Neurocase, 5, 345-354. DOI: https://doi.org/10.1080/13554799908411987

Dvash, J. y Shamay-Tsoory, S. (2014). Theory of Mind and Empathy as Multidimensional Constructs. Topics in Language Disorders, 34(4), pp.282-295 DOI: https://doi.org/10.1097/TLD.0000000000000040

Eslinger PJ, Damasio AR. (1985). Severe disturbance of higher cognition after bilateral frontal lobe ablations: patient EVR. Neurology. 1985; 35:1731–1741. DOI: https://doi.org/10.1212/WNL.35.12.1731

Gregory C, Lough S, Stone V, Erzinclioglu S, Martin L, Baron-Cohen S, et al. (2002). Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer’s disease: theoretical and practical implications. Brain. 2002;125(4):752–64. DOI: https://doi.org/10.1093/brain/awf079

Harlow, J.M. (1868). Recovery from the passage of an iron bar through the head. PublMass Med Soc 2, 327–347.

Ibáñez, A., Sedeño, L., & García, A. (2017). Neuroscience and Social Science - The Missing Link. Cham, Switzerland: Springer International Publishing Switzerland. DOI: https://doi.org/10.1007/978-3-319-68421-5

Ibáñez A, Aguado J, Baez S, Huepe D, López V, Ortega R, et al. (2013). From neural signatures of emotional modulation to social cognition: individual differences in healthy volunteers and psychiatric participants. Soc Cogn Affect Neurosci. 2013;9:939–50. DOI: https://doi.org/10.1093/scan/nst067

Koenigs, M., Huey, E.D., Calamia, M., Raymont, V., Tranel, D., Grafman, J. (2008). Distinct regions of prefrontal cortex mediate resistance and vulnerability to depression. The Journal of Neuroscience, 28(47), 12341–8. DOI: https://doi.org/10.1523/JNEUROSCI.2324-08.2008

Leopold, A., Krueger, F., Dal monte, O., Pardini, M., Pulaski, S.J., Solomon, J., Grafman, J., (2012). Damage to the left ventromedial prefrontal cortex impacts affective theory of mind. Soc. Cogn. Affect. Neurosci. 7, 871–880. DOI: https://doi.org/10.1093/scan/nsr071

Lezak, M.D. (1978). Living with the characterologically altered brain-injured patient. Journal of Clinical Psychology, 39, 592–598.

Lieberman, M.D. (2007). Social cognitive neuroscience: A review of core processes. Annual Review of Psychology, 58, 259–289. DOI: https://doi.org/10.1146/annurev.psych.58.110405.085654

May, M., Milders, M., Downey, B., Whyte, M., Higgins, V., Wojcik, Z., O’Rourke, S. (2017). Social Behavior and Impairments in Social Cognition Following Traumatic Brain Injury. Journal of the International Neuropsychological Society. https://doi.org/10.1017/S1355617717000182 DOI: https://doi.org/10.1017/S1355617717000182

McDonald S. (2010). Exploring the process of inference generation in sarcasm: a review of normal and clinical studies. Brain Lang. 1999; 68:486–506. DOI: https://doi.org/10.1006/brln.1999.2124

Mcdonald, S. (2013). Impairments in Social Cognition Following Severe Traumatic Brain Injury. Journal of the International Neuropsychological Society, 19, 231–246. https://doi.org/10.1017/S1355617712001506 DOI: https://doi.org/10.1017/S1355617712001506

Ministerio de Salud y Protección Social - Colciencias. (2015). Guía práctica clínica Ataque cerebrovascular isquémico. Obtenido de http://guia-acv.com/

Muñoz-Collazos, M. (2010). Enfermedad cerebrovascular. Acta Neurol. Colomb, 26(2), 33.

Njomboro, P. (2017). Social Cognition Deficits: Current Position and Future Directions for Neuropsychological Interventions in Cerebrovascular Disease. Behavioral Neurology. https://doi.org/10.1155/2017/2627487 DOI: https://doi.org/10.1155/2017/2627487

Ospina, N. (2015). Adaptación y Validación en Colombia del Addenbrooke‘s Cognitive ExaminationRevisado (ACE-R) en pacientes con Deterioro Cognoscitivo Leve y Demencia. Obtenido de http://bdigital.unal.edu.co/46616/1/05599183.2015.pdf

Petrides, M. (2005). Lateral prefrontal cortex: architectonic y functional organization. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 360, 781-795. DOI: https://doi.org/10.1098/rstb.2005.1631

Rowe AD, Bullock PR, Polkey CE, et al. (2001) ‘‘Theory of mind’’ impairments and their relationship to executive functioning following frontal lobe excisions. Brain. 2001; 124:600–616. DOI: https://doi.org/10.1093/brain/124.3.600

Schneider, B., & Koenigs, M. (2017). Human lesion studies of ventromedial prefrontal cortex. Neuropsychology. https://doi.org/10.1016/j.neuropsychologia.2017.09.035 DOI: https://doi.org/10.1016/j.neuropsychologia.2017.09.035

Shamay SG, Tomer R, Aharon-Peretz J. (2002). Deficit in understanding sarcasm in patients with prefrontal lesion is related to impaired empathic ability. Brain Cogn. 2002; 48:558–563. DOI: https://doi.org/10.1006/brcg.2001.1417

Shamay-Tsoory, S. G., Tomer, R., Berger, B. D., & Aharon-Peretz, J. (2003). Characterization of Empathy Deficits following Prefrontal Brain Damage: The Role of the Right Ventromedial Prefrontal Cortex. Journal of Cognitive Neuroscience. https://doi.org/10.1162/089892903321593063 DOI: https://doi.org/10.1162/089892903321593063

Shamay-Tsoory, S. G., Tomer, R., Berger, B. D., Goldsher, D., & Aharon-Peretz, J. (2005.). Impaired Affective Theory of Mind’’ Is Associated with Right Ventromedial Prefrontal Damage. Cog Behav Neurol. DOI: https://doi.org/10.1097/01.wnn.0000152228.90129.99

Shamay-Tsoory, S. G., Tibi-Elhanany, Y., & Aharon-Peretz, J. (2006). The ventromedial prefrontal cortex is involved in understanding affective but not cognitive theory of mind stories. Social Neuroscience. https://doi.org/10.1080/17470910600985589 DOI: https://doi.org/10.1080/17470910600985589

Shamay-Tsoory, S. G., Tomer, R., Goldsher, D., Berger, B. D., & Aharon-Peretz, J. (2004). Impairment in cognitive and affective empathy in patients with brain lesions: Anatomical and cognitive correlates. Journal of Clinical and Experimental Neuropsychology. https://doi.org/10.1080/13803390490515531 DOI: https://doi.org/10.1080/13803390490515531

Shamay-Tsoory, S. G., Aharon-Peretz, J., & Perry, D. (2009). Two systems for empathy: A double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain. https://doi.org/10.1093/brain/awn279 DOI: https://doi.org/10.1093/brain/awn279

Stone VE, Baron-Cohen S, Knight RT. (1998) Frontal lobe contributions to theory of mind. J Cogn Neurosci. 1998; 10:640–656. DOI: https://doi.org/10.1162/089892998562942

Stuss, D.T., Bisschop, S.M., Alexander, M.P., Levine, B., Katz, D., & Izukawa, D. (2001). The Trail Making Test: A study in focal lesion patients. Psychological Assessment, 13, 230– 239. DOI: https://doi.org/10.1037/1040-3590.13.2.230

Stuss DT, Gallup GG Jr, Alexander MP. (2001) The frontal lobes are necessary for ‘‘theory of mind.’’ Brain. 2001; 124:279–286. DOI: https://doi.org/10.1093/brain/124.2.279

Torralva T, Roca M, Gleichgerrcht E, Lopez P, and Manes F. (2009) INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia. Journal of the International Neuropsychological Society, 15(5): 777e786, 2009. DOI: https://doi.org/10.1017/S1355617709990415

Winner E. (1998). The Point of Words: Children Understanding of Metaphor and Irony. Cambridge, MA: Harvard University Press; 1998.

Young, L., Bechara, A., Tranel, D., Damasio, H., Hauser, M., & Damasio, A. (2010). Damage to Ventromedial Prefrontal Cortex Impairs Judgment of Harmful Intent. Neuron. https://doi.org/10.1016/j.neuron.2010.03.003 DOI: https://doi.org/10.1016/j.neuron.2010.03.003

How to Cite

APA

Sánchez Tombe, J. R. (2022). Lesions in the Ventromedial Prefrontal Cortex and their Impact on Social Cognition. Revista Colombiana de Psicología, 31(2), 11–26. https://doi.org/10.15446/rcp.v31n2.88206

ACM

[1]
Sánchez Tombe, J.R. 2022. Lesions in the Ventromedial Prefrontal Cortex and their Impact on Social Cognition. Revista Colombiana de Psicología. 31, 2 (Jul. 2022), 11–26. DOI:https://doi.org/10.15446/rcp.v31n2.88206.

ACS

(1)
Sánchez Tombe, J. R. Lesions in the Ventromedial Prefrontal Cortex and their Impact on Social Cognition. Rev. colomb. psicol. 2022, 31, 11-26.

ABNT

SÁNCHEZ TOMBE, J. R. Lesions in the Ventromedial Prefrontal Cortex and their Impact on Social Cognition. Revista Colombiana de Psicología, [S. l.], v. 31, n. 2, p. 11–26, 2022. DOI: 10.15446/rcp.v31n2.88206. Disponível em: https://revistas.unal.edu.co/index.php/psicologia/article/view/88206. Acesso em: 28 mar. 2024.

Chicago

Sánchez Tombe, José Raul. 2022. “Lesions in the Ventromedial Prefrontal Cortex and their Impact on Social Cognition”. Revista Colombiana De Psicología 31 (2):11-26. https://doi.org/10.15446/rcp.v31n2.88206.

Harvard

Sánchez Tombe, J. R. (2022) “Lesions in the Ventromedial Prefrontal Cortex and their Impact on Social Cognition”, Revista Colombiana de Psicología, 31(2), pp. 11–26. doi: 10.15446/rcp.v31n2.88206.

IEEE

[1]
J. R. Sánchez Tombe, “Lesions in the Ventromedial Prefrontal Cortex and their Impact on Social Cognition”, Rev. colomb. psicol., vol. 31, no. 2, pp. 11–26, Jul. 2022.

MLA

Sánchez Tombe, J. R. “Lesions in the Ventromedial Prefrontal Cortex and their Impact on Social Cognition”. Revista Colombiana de Psicología, vol. 31, no. 2, July 2022, pp. 11-26, doi:10.15446/rcp.v31n2.88206.

Turabian

Sánchez Tombe, José Raul. “Lesions in the Ventromedial Prefrontal Cortex and their Impact on Social Cognition”. Revista Colombiana de Psicología 31, no. 2 (July 18, 2022): 11–26. Accessed March 28, 2024. https://revistas.unal.edu.co/index.php/psicologia/article/view/88206.

Vancouver

1.
Sánchez Tombe JR. Lesions in the Ventromedial Prefrontal Cortex and their Impact on Social Cognition. Rev. colomb. psicol. [Internet]. 2022 Jul. 18 [cited 2024 Mar. 28];31(2):11-26. Available from: https://revistas.unal.edu.co/index.php/psicologia/article/view/88206

Download Citation

CrossRef Cited-by

CrossRef citations0

Dimensions

PlumX

Article abstract page views

636

Downloads

Download data is not yet available.