Carcinoma de células de Merkel primario de la mama en un hombre con injerto cutáneo. Reporte de caso

Publicado

2023-01-01

Primary Merkel cell carcinoma of the breast in a man with skin graft: a case report

Carcinoma de células de Merkel primario de la mama en un hombre con injerto cutáneo. Reporte de caso

Palabras clave:

Carcinoma Merkel Cell, Merkel Cells, Merkel cell polyomavirus, Breast, Breast Diseases (en)
Carcinoma de Células de Merkel, Células de Merkel, Poliomavirus de Células de Merkel, Mama, Enfermedades de la Mama (es)

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Autores/as

Yoandry Calderón-Montero Instituto Nacional de Oncología y Radiobiología - Servicio de Radiología - La Habana - Cuba. https://orcid.org/0000-0002-9439-9117
Naibel Quevedo-Ramírez Instituto Nacional de Oncología y Radiobiología - Servicio de Radiología - La Habana - Cuba. https://orcid.org/0000-0002-5769-2314
María de la Caridad Campos-Bernardo Instituto Nacional de Oncología y Radiobiología - Servicio de Radiología - La Habana - Cuba. https://orcid.org/0000-0001-8973-8906
Raydel Pérez-Castillo Instituto de Medicina del Deporte - La Habana - Cuba. https://orcid.org/0000-0001-9454-5375

Resumen (en)
Resumen (es)

Introduction: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that usually appears as a flesh-colored or bluish-red nodule on the face, head, or neck. MCC is primarily found in older adults.

Case presentation: An 85-year-old white man visited the breast care service of the Servicio de Mastología del Instituto Nacional de Oncología y Radiobiología (National Institute of Oncology and Radiobiology, or INOR by its acronym in Spanish) in Havana, Cuba, due to an increase in volume, color change, and a burning sensation in the right breast. The patient had suffered thermal trauma to the right hemithorax 18 years before the consultation, which was treated with a skin graft of the thigh. Imaging studies (ultrasound, mammography, magnetic resonance imaging, and computed tomography) showed a nodule with imaging features suggestive of malignancy. CCM diagnosis was confirmed by core needle biopsy, reporting positivity of CD-56, CK-7, and Ki-67 markers.

Conclusions. Typically, MCC presents as a rapidly growing, firm skin nodule in sun-exposed areas, contrary to the present case, in which the lesion appeared on grafted skin on the right hemithorax. Recognizing imaging findings suggestive of this neoplasm is of great importance for its diagnosis in unusual areas of the body, such as the breast.

Introducción. El carcinoma de células de Merkel (CCM) es un cáncer neuroendocrino de la piel agresivo y muy poco frecuente que, por lo general, aparece como un nódulo de color carne o rojo azulado en la cara, cabeza o cuello. El CCM ocurre principalmente en adultos mayores.

Presentación del caso. Hombre de 85 años, blanco, que asistió al Servicio de Mastología del Instituto Nacional de Oncología y Radiobiología (INOR), en La Habana, Cuba, por aumento de volumen, cambio de color y temperatura en la mama derecha. El paciente había sufrido trauma térmico en el hemitórax derecho 18 años antes de la consulta, el cual fue tratado mediante injerto cutáneo del muslo. En los estudios de imagen (ultrasonido, mamografía, resonancia magnética y tomografía computarizada) se observó un nódulo con características imagenológicas sugestivas de malignidad. El diagnóstico de CCM se confirmó mediante biopsia por punción con aguja gruesa, donde se reportó positividad de marcadores CD-56, CK-7 y Ki-67.

Conclusiones. Característicamente, el CCM se presenta como nódulos cutáneos firmes de rápido crecimiento en las áreas expuestas al sol, a diferencia del presente caso, en el que la lesión apareció en la piel injertada en el hemitórax derecho. Reconocer hallazgos imagenológicos sugestivos de esta neoplasia es de gran importancia para el diagnóstico en zonas inusuales del cuerpo como la mama.

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Citas

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