Published

1993-04-01

Citogenética del retinoblastoma

Keywords:

retinoblastoma, rearreglo cromosómico, progresión tumoral, gen supresor tumoral (es)

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Authors

  • Oscar Oliveros G. Universidad Nacional de Colombia
  • Josefina Cano C. Universidad Nacional de Colombia
  • Emilio Yunis Universidad Nacional de Colombia

EI retinoblastoma se ha constituido en un paradigma de la genética de los tumores sólidos, principalmente por permitir el hallazgo de un nueva categoría de genes vinculados con procesos neoplásicos: los genes supresores tumorales o antloncogenes. EI presente trabajo es un amplio análisis citogenético de 38 retinoblastomas primarios, e informa acerca de los rearreglos cromosómicos comunes y sus frecuencias: polisomias de lq (66%), copias adicionales de 6p (47%), deleción de 13q (21%), deleción de 16q (66%), deleción de 17p (26%), y presencia de regiones eremosómicas amplificadas (l 1%). Se discute el posible papel de cada uno de estos rearreglos en consideración a recientes hallazgos moleculares de genes mapeados en los segmentos cromosómicos implicados.

How to Cite

APA

Oliveros G., O., Cano C., J. and Yunis, E. (1993). Citogenética del retinoblastoma. Revista de la Facultad de Medicina, 41(2), 70–77. https://revistas.unal.edu.co/index.php/revfacmed/article/view/27239

ACM

[1]
Oliveros G., O., Cano C., J. and Yunis, E. 1993. Citogenética del retinoblastoma. Revista de la Facultad de Medicina. 41, 2 (Apr. 1993), 70–77.

ACS

(1)
Oliveros G., O.; Cano C., J.; Yunis, E. Citogenética del retinoblastoma. Rev. Fac. Med. 1993, 41, 70-77.

ABNT

OLIVEROS G., O.; CANO C., J.; YUNIS, E. Citogenética del retinoblastoma. Revista de la Facultad de Medicina, [S. l.], v. 41, n. 2, p. 70–77, 1993. Disponível em: https://revistas.unal.edu.co/index.php/revfacmed/article/view/27239. Acesso em: 23 jul. 2024.

Chicago

Oliveros G., Oscar, Josefina Cano C., and Emilio Yunis. 1993. “Citogenética del retinoblastoma”. Revista De La Facultad De Medicina 41 (2):70-77. https://revistas.unal.edu.co/index.php/revfacmed/article/view/27239.

Harvard

Oliveros G., O., Cano C., J. and Yunis, E. (1993) “Citogenética del retinoblastoma”, Revista de la Facultad de Medicina, 41(2), pp. 70–77. Available at: https://revistas.unal.edu.co/index.php/revfacmed/article/view/27239 (Accessed: 23 July 2024).

IEEE

[1]
O. Oliveros G., J. Cano C., and E. Yunis, “Citogenética del retinoblastoma”, Rev. Fac. Med., vol. 41, no. 2, pp. 70–77, Apr. 1993.

MLA

Oliveros G., O., J. Cano C., and E. Yunis. “Citogenética del retinoblastoma”. Revista de la Facultad de Medicina, vol. 41, no. 2, Apr. 1993, pp. 70-77, https://revistas.unal.edu.co/index.php/revfacmed/article/view/27239.

Turabian

Oliveros G., Oscar, Josefina Cano C., and Emilio Yunis. “Citogenética del retinoblastoma”. Revista de la Facultad de Medicina 41, no. 2 (April 1, 1993): 70–77. Accessed July 23, 2024. https://revistas.unal.edu.co/index.php/revfacmed/article/view/27239.

Vancouver

1.
Oliveros G. O, Cano C. J, Yunis E. Citogenética del retinoblastoma. Rev. Fac. Med. [Internet]. 1993 Apr. 1 [cited 2024 Jul. 23];41(2):70-7. Available from: https://revistas.unal.edu.co/index.php/revfacmed/article/view/27239

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