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Cardiovascular medication scheduling patterns in light of chronopharmacology: A descriptive nursing study
Patrones de programación de medicamentos cardiovasculares a la luz de la cronofarmacología: estudio descriptivo de enfermería
Padrões de programação de medicação cardiovascular à luz da cronopramcologia: um estudo descritivo de enfermagem
DOI:
https://doi.org/10.15446/av.enferm.v43n2.122182Keywords:
Cardiovascular Drugs, Chronotherapy, Circadian Rhythm, Drug Chronotherapy, Nursing (en)Fármacos Cardiovasculares, Cronoterapia, Ritmo Circadiano, Cronoterapia de Medicamentos, Enfermería (es)
Fármacos Cardiovasculares, Cronoterapia, Ritmo Circadiano, Cronofarmacoterapia, Enfermagem (pt)
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Objective: To describe the schedules for administering cardiovascular medications in light of chronopharmacology.
Methodology: This prospective, cross-sectional, and descriptive study reviewed the medication records of adult patients discharged from a hospital ward who received systemic cardiovascular drugs prescribed once daily.
Results: A total of 753 once-daily prescriptions were analyzed across seven therapeutic drug groups. Most medications were scheduled for morning administration, with 08:00 being the most frequent time. Statins were administered almost exclusively at night, whereas diuretics, beta-blockers, and angiotensin II receptor antagonists were
mainly given in the morning. Notable variation was observed within medication groups, indicating the lack of chronopharmacological criteria in the scheduling.
Conclusions: The administration of once-daily cardiovascular medications showed distinct timing patterns across therapeutic groups, with variability even among drugs within the same group, highlighting the lack of systematic chronopharmacological criteria for their
scheduling. These results underscore the importance of integrating chronopharmacology into nursing practice to promote safer, more effective administration of cardiovascular medications and to strengthen evidence-based decision-making in pharmacological care.
Objetivo: describir los horarios de administración de los medicamentos cardiovasculares a la luz de la cronofarmacología.
Materiales y métodos: estudio prospectivo, transversal y descriptivo. Se analizaron tarjetas de medicamentos de pacientes adultos que egresaron de un servicio de hospitalización y recibieron fármacos cardiovasculares de administración sistémica en régimen de una sola dosis diaria.
Resultados: se analizaron 753 prescripciones de medicamentos cardiovasculares administrados una vez al día, distribuidas en siete grupos terapéuticos. La mayoría de los fármacos se programaron en horarios matutinos y las 8:00 fue la hora más frecuente. Las estatinas se administraron casi exclusivamente en la noche, mientras que los diuréticos, los bloqueadores beta y los antagonistas del receptor de angiotensina II mostraron una marcada preferencia por la mañana. Se observaron variaciones significativas entre los medicamentos de cada grupo, lo que evidencia la ausencia de criterios cronofarmacológicos en la programación.
Conclusiones: la administración de medicamentos cardiovasculares una vez al día presentó patrones temporales diferenciados según el grupo terapéutico, con variabilidad entre fármacos de un mismo grupo, lo que evidencia la ausencia de criterios cronofarmacológicos sistemáticos en su programación. Estos resultados destacan la importancia de integrar la cronofarmacología en la práctica de enfermería para favorecer una administración más segura y eficaz de los medicamentos cardiovasculares y para fortalecer la toma de decisiones basada en la evidencia del cuidado farmacológico.
Objetivo: Descrever os horários para a administração de medicamentos cardiovasculares à luz da cronofarmacologia.
Metodologia: Este estudo prospectivo, transversal e descritivo revisou os registros de medicamentos de pacientes adultos egressos de uma enfermaria hospitalar que receberam medicamentos cardiovasculares sistêmicos prescritos uma vez ao dia.
Resultados: Um total de 753 prescrições de dose única diária foi analisado em sete grupos terapêuticos de medicamentos. A maioria dos medicamentos foi programada para administração matinal, sendo às 8h o horário mais frequente. As estatinas foram administradas quase exclusivamente à noite, enquanto diuréticos, betabloqueadores e antagonistas dos receptores da angiotensina II foram administrados principalmente pela manhã. Observou-se variação notável dentro dos grupos de medicamentos, indicando a ausência de critérios cronofarmacológicos no agendamento.
Conclusões: A administração de medicamentos cardiovasculares de dose única diária apresentou padrões de administração distintos, dependendo do grupo terapêutico, com variabilidade até mesmo entre medicamentos do mesmo grupo, evidenciando a falta de critérios cronofarmacológicos sistemáticos em sua programação. Esses resultados reforçam a importância da integração da cronofarmacologia à prática de enfermagem para promover uma administração mais segura e eficaz de medicamentos cardiovasculares e fortalecer a tomada de decisões baseada em evidências no cuidado farmacológico.
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Copyright (c) 2025 Leidy Yurany Cárdenas Parra, Oswaldo Juan Arroyave Cardona, John Edison Cárdenas Galvis, Lorena Gómez Giraldo
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