Publicado

2018-07-01

TOXINAS DE Bacillus thuringiensis CON ACTIVIDAD ANTICANCERÍGENA: PARASPORINAS

TOXINS OF Bacillus thuringiensis WITH ANTICANCER ACTIVITY: PARASPORINS

TOXINAS DE Bacillus thuringiensis COM ATIVIDADE ANTICANCER: PARASPORINS

DOI:

https://doi.org/10.15446/rev.colomb.biote.v20n2.73668

Palabras clave:

Cáncer, línea celular, receptor, toxina Cry (es)
cancer, cell line, receptor, Cry Toxin (en)
câncer, linha celular, receptor, toxina Cry (pt)

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Autores/as

  • Luisa Fernanda Velásquez Cardona Universidad Nacional de Colombia
  • Danithza Sirley Rojas Torres Universidad Nacional de Colombia
  • Jairo Cerón Salamanca Universidad Nacional de Colombia

Las toxinas Cry de Bacillus thuringiensis (Bt) han sido reconocidas por su acción biocontroladora contra insectos plaga. Recientemente se ha descrito que algunas cepas de Bt presentan proteínas que no presentan actividad insecticida, pero al ser enfrentadas a líneas celulares de cáncer de diferentes tipos han demostrado actividad citotóxica. Estas proteínas han sido denominadas parasporinas (PS) y surgen como una potencial alternativa para el tratamiento del cáncer debido a que presentan alta citotoxicidad hacia diferentes líneas celulares cancerígenas, y baja o nula citotoxicidad hacia células normales.

Cry toxins from Bacillus thuringiensis (Bt) have been recognized for their biocontrol action against insect pests. Recently it has been described some strains of Bt produce proteins without insecticidal activity, but when cancer cell lines of different types are exposed to these proteins they have demonstrated cytotoxic activity. These proteins have been called parasporins (PS) and are a potential alternative for the treatment of cancer because they have high cytotoxicity in different cancer cell lines, and null or low toxic activity in normal cells.

As toxinas Cry de Bacillus thuringiensis (Bt) foram reconhecidas por sua ação de biocontrole contra pragas de insetos. Recentemente tem sido descrito que algumas cepas de Bt produzem proteínas sem atividade inseticida, mas quando linhagens de células de câncer de diferentes tipos são expostas a essas proteínas, elas demonstraram atividade citotóxica. Essas proteínas têm sido chamadas de parasporinas (PS) e são uma alternativa em potencial para o tratamento do câncer, pois apresentam alta citotoxicidade em diferentes linhagens de células cancerígenas e pouca ou nenhuma atividade tóxica em células normais.

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Cómo citar

APA

Velásquez Cardona, L. F., Rojas Torres, D. S. y Cerón Salamanca, J. (2018). TOXINAS DE Bacillus thuringiensis CON ACTIVIDAD ANTICANCERÍGENA: PARASPORINAS. Revista Colombiana de Biotecnología, 20(2), 89–100. https://doi.org/10.15446/rev.colomb.biote.v20n2.73668

ACM

[1]
Velásquez Cardona, L.F., Rojas Torres, D.S. y Cerón Salamanca, J. 2018. TOXINAS DE Bacillus thuringiensis CON ACTIVIDAD ANTICANCERÍGENA: PARASPORINAS. Revista Colombiana de Biotecnología. 20, 2 (jul. 2018), 89–100. DOI:https://doi.org/10.15446/rev.colomb.biote.v20n2.73668.

ACS

(1)
Velásquez Cardona, L. F.; Rojas Torres, D. S.; Cerón Salamanca, J. TOXINAS DE Bacillus thuringiensis CON ACTIVIDAD ANTICANCERÍGENA: PARASPORINAS. Rev. colomb. biotecnol. 2018, 20, 89-100.

ABNT

VELÁSQUEZ CARDONA, L. F.; ROJAS TORRES, D. S.; CERÓN SALAMANCA, J. TOXINAS DE Bacillus thuringiensis CON ACTIVIDAD ANTICANCERÍGENA: PARASPORINAS. Revista Colombiana de Biotecnología, [S. l.], v. 20, n. 2, p. 89–100, 2018. DOI: 10.15446/rev.colomb.biote.v20n2.73668. Disponível em: https://revistas.unal.edu.co/index.php/biotecnologia/article/view/73668. Acesso em: 27 ene. 2025.

Chicago

Velásquez Cardona, Luisa Fernanda, Danithza Sirley Rojas Torres, y Jairo Cerón Salamanca. 2018. «TOXINAS DE Bacillus thuringiensis CON ACTIVIDAD ANTICANCERÍGENA: PARASPORINAS». Revista Colombiana De Biotecnología 20 (2):89-100. https://doi.org/10.15446/rev.colomb.biote.v20n2.73668.

Harvard

Velásquez Cardona, L. F., Rojas Torres, D. S. y Cerón Salamanca, J. (2018) «TOXINAS DE Bacillus thuringiensis CON ACTIVIDAD ANTICANCERÍGENA: PARASPORINAS», Revista Colombiana de Biotecnología, 20(2), pp. 89–100. doi: 10.15446/rev.colomb.biote.v20n2.73668.

IEEE

[1]
L. F. Velásquez Cardona, D. S. Rojas Torres, y J. Cerón Salamanca, «TOXINAS DE Bacillus thuringiensis CON ACTIVIDAD ANTICANCERÍGENA: PARASPORINAS», Rev. colomb. biotecnol., vol. 20, n.º 2, pp. 89–100, jul. 2018.

MLA

Velásquez Cardona, L. F., D. S. Rojas Torres, y J. Cerón Salamanca. «TOXINAS DE Bacillus thuringiensis CON ACTIVIDAD ANTICANCERÍGENA: PARASPORINAS». Revista Colombiana de Biotecnología, vol. 20, n.º 2, julio de 2018, pp. 89-100, doi:10.15446/rev.colomb.biote.v20n2.73668.

Turabian

Velásquez Cardona, Luisa Fernanda, Danithza Sirley Rojas Torres, y Jairo Cerón Salamanca. «TOXINAS DE Bacillus thuringiensis CON ACTIVIDAD ANTICANCERÍGENA: PARASPORINAS». Revista Colombiana de Biotecnología 20, no. 2 (julio 1, 2018): 89–100. Accedido enero 27, 2025. https://revistas.unal.edu.co/index.php/biotecnologia/article/view/73668.

Vancouver

1.
Velásquez Cardona LF, Rojas Torres DS, Cerón Salamanca J. TOXINAS DE Bacillus thuringiensis CON ACTIVIDAD ANTICANCERÍGENA: PARASPORINAS. Rev. colomb. biotecnol. [Internet]. 1 de julio de 2018 [citado 27 de enero de 2025];20(2):89-100. Disponible en: https://revistas.unal.edu.co/index.php/biotecnologia/article/view/73668

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