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Tumor del estroma gastrointestinal: Informe de caso y revisión de la literatura
Keywords:
Tumor del Estroma Gastrointestinal; Neoplasias Gástricas; Inmunohistoquímica; Informe de Caso (es)Gastrointestinal Stromal Tumor; Stomach Neoplasm; Immunohistochemistry; Case Report (en)
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El tumor del estroma gastrointestinal (GIST) es infrecuente; sin embargo, corresponde a la neoplasia de origen mesenquimal más común del tracto gastrointestinal. Se informa el caso de un paciente de 60 años con GIST gástrico, que se manifestó como hemorragia de vías digestivas de alto riesgo y síndrome constitucional; fue tratado con citorreducción tumoral quirúrgica de urgencia mediante gastrectomía subtotal. La presentación clínica de esta entidad es muy inespecífica, por lo cual se convierte en un reto de diagnóstico tanto clínico como patológico y requiere un profundo conocimiento histo-morfológico de la pared gástrica.
Gastrointestinal Stromal Tumor (GIST) is unusual; however corresponds to the most common mesenchymal neoplasm in the gastrointestinal tract. In this report we present a case of gastric GIST in a 60-year-old man, who presented high risk upper gastrointestinal bleeding and constitutional syndrome; was treated with urgent surgical tumoral reduction (subtotal gastrectomy). This entity has very unspecific manifestations which makes it clinical as well as a pathological diagnostic challenge, requiring a deep knowledge of the gastric wall histomorphology.
References
Trisha M.P, Michael J.D, Alexander M.B, Salvatore A.G, et Al. Gastrointestinal stromal tumors: a comprehensive review. J Gastrointest Oncol. 2019;10(1):144‐154.
Søreide K, Sandvik O,M, Søreide J.A, Giljaca V, Jureckova A, Bulusu V.R. Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies. Cancer Epidemiol. 2016;40(1):39-46.
Scherubl H, Faiss S, Knoefel WT, et Al. Management of early asymptomatic gastrointestinal stromal tumors of the stomach. World J Gastrointest Endosc. 2014;6(7):266-71.
Rammohan A, Sathyanesan J, Rajendran K, et al. A gist of gastrointestinal stromal tumors: A review. World J Gastrointest Oncol. 2013; 5(6): 102–112.
Chen Y.H, Liu K.H, Yeh C.N, et Al. Laparoscopic resection of gastrointestinal stromal tumors: safe, efficient, and comparable oncologic outcomes. J Laparoendosc Adv Surg Tech A. 2012; 22(8):758-63.
Amin M.B, Edge S.B, Greene F.L, et Al. AJCC Cancer Staging Manual. 8th Ed. New York, United States of America: Springer, 2017.
Agaimy A, Wünsch P.H, Hofstaedter F, Blaszyk H, Rümmele P, Gaumann A, Dietmaier W, Hartmann A. Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutations. Am J Surg Pathol. 2007;31(1):113-20.
Rubin B.P, Heinrich M.C, Corless C.L. Gastrointestinal stromal tumour. Lancet. 2007;369(9574):1731-41.
Miettinen M, Sobin L.H, Sarlomo-Rikala M. Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT). Mod Pathol. 2000;13(10):1134-42.
Neves M.C, Stamp G, Mudan S. Sporadic diffuse segmental interstitial cell of Cajal hyperplasia harbouring two gastric gastrointestinal stromal tumours (GIST) mimicking hereditary GIST syndromes. Int J Surg Case Rep. 2015;16(1):202-5.
Marcella C, Shi R.H, Sarwar S. Clinical Overview of GIST and Its Latest Management by Endoscopic Resection in Upper GI: A Literature Review. Gastroenterol Res Pract. 2018 Oct 31;2018:6864256.
Scarpa M, Bertin M, Ruffolo C, Polese L, D'Amico D.F, Angriman I. A systematic review on the clinical diagnosis of gastrointestinal stromal tumors. J. Surg. Oncol. 2008; 98(5):384-392.
Kamiyama Y, Aihara R, Nakabayashi T, Mochiki E, Asao T, Kuwano H, Oriuchi N, Endo K. 18F-fluorodeoxyglucose positron emission tomography: useful technique for predicting malignant potential of gastrointestinal stromal tumors. World J Surg. 2005;29(11):1429-35.
Casali P, Abecassis N, Bauer S, Biagini R, Bielack S, Bonvalot S et al. Gastrointestinal stromal tumours: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2018;29(1):68-78.
Shim C.N, Song M.K, Kang D.R, Chung H.S, Park J.C, et Al. Size discrepancy between endoscopic size and pathologic size is not negligible in endoscopic resection for early gastric cancer. Surg Endosc. 2014; 28(7):2199-207.
Tran T, Sundaram C.P, Bahler C.D, et al. Correcting the Shrinkage Effects of Formalin Fixation and Tissue Processing for Renal Tumors: toward Standardization of Pathological Reporting of Tumor Size. J Cancer. 2015;6(8):759-766.
Hsu P.K, Huang H.C, et Al. Effect of Formalin Fixation on Tumor Size Determination in Stage I Non-Small Cell Lung Cancer. Ann Thorac Surg. 2007;84(6),1825–1829.
Fletcher C.D, Berman J.J, Corless C, Gorstein F, Lasota J, Longley B.J, et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol. 2002;33(5):459-65.
Kang G.H, Srivastava A, Kim Y.E, Park H.J, Park C.K, Sohn T.S, et Al. DOG1 and PKC-θ are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors. Mod Pathol. 2011;24(6):866-75.
Joensuu H. Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol. 2008;39(10):1411-9.
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Copyright (c) 2021 Andrés Ricardo Latorre Rodríguez , Camilo Andrés Mateus Patarroyo , Natalia Olaya
This work is licensed under a Creative Commons Attribution 4.0 International License.
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