Publicado

2025-07-08

Thermodynamic analysis and preferential solvation of metronidazole solubility in methanol-water and ethanol-water cosolvent mixtures at different temperatures

Análisis termodinámico y solvatación preferencial de la solubilidad del metronidazol en mezclas cosolventes metanol-agua y etanol-agua a diferentes temperaturas

Análise termodinâmica e solvatação preferencial da solubilidade do metronidazol em misturas de metanol-água e etanol-água a diferentes temperaturas

DOI:

https://doi.org/10.15446/rcciquifa.v54n2.121131

Palabras clave:

Solubility, metronidazole, solution thermodynamics, enthalpy-entropy compensation, preferential solvation (en)
Solubilidad, metronidazol, termodinámica de soluciones, compensación entalpía-entropía, solvatación preferencial (es)
solubilidade, metronidazol, termodinâmica de soluções, compensação entalpia-entropia, solvatação preferencial (pt)

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Autores/as

  • German Fabian Escobar Fiesco Departamento Matemática y Estadística, Universidad Surcolombiana, Avenida Pastrana Borrero, Ca-rrera 1, Neiva, 410001, Huila, Colombia
  • Diego Ivan Caviedes-Rubio Grupo de Investigación de Ingenierías UCC-Neiva, Facultad de Ingeniería, Programa de Ingeniería Civil, Universidad Cooperativa de Colombia, Calle 11 N 1f-97, Neiva, 410001, Huila, Colombia
  • Claudia Patricia Ortiz Sifati Group Ingeniería S.A.S., Grupo de Investigaciones Ciencia, Ingeniería e Innovación, Palermo, Huila, Colombia
  • Yaqueline Quintero Guerrero Maestría en Ingeniería y Gestión Ambiental, Universidad Surcolombiana, Avenida Pastrana Borrero, Carrera 1, Neiva, 410001, Huila, Colombia
  • Néstor Enrique Cerquera Programa de Ingeniería Agrícola, Universidad Surcolombiana, Avenida Pastrana Borrero, Carrera 1, Neiva, 410001, Huila, Colombia
  • Cristian Rincón-Guio Rectoría Virtual, Ingeniería Industrial, Corporación Universitaria Minuto de Dios-UNIMINUTO, Bo-gotá 110321, Cundinamarca, Colombia
  • Rossember Edén Cardenas-Torres Grupo de Investigación ENERDIMAT, Facultad de Ciencias y Humanidades, Fundación Universidad de América, Avenida Circunvalar No. 20-53, Bogotá D.C, 110321, Bogotá, Colombia
  • Daniel Ricardo Delgado Grupo de Investigación de Ingenierías UCC-Neiva, Facultad de Ingeniería, Programa de Ingeniería Civil, Universidad Cooperativa de Colombia, Calle 11 N 1f-97, Neiva, 410001, Huila, Colombia

 Introduction: Solubility is one of the most important physicochemical properties because it is related to some industrial processes such as: formulation, preformulation, purification and quantification. Objective: This paper presents the thermodynamic analysis of the solubility of metronidazole in methanolwater and ethanolwater cosolvent mixtures at seven temperatures. Methodology: From solubility data, the thermodynamic functions of solution and mixture are calculated and analysed using the Perlovich graphical method. On the other hand, an enthalpyentropy compensation analysis is performed, and the preferential solvation parameters are calculated using the inverse KirkwoodBuff integral (IKBI) method. Results: The result of the calculations performed indicates that the dissolution process of metronidazole is endothermic with entropic preference, where the addition of methanol and ethanol has a positive cosolvent effect in intermediate and waterrich mixtures. With regard to preferential solvation, the results are not entirely conclusive, since, except in intermediate mixtures, the values of the preferential solvation parameter are less than 0.01, so that negligible preferential solvation takes place.

Introducción: La solubilidad es una de las propiedades fisicoquímicas más importantes, puesto que está relacionada con algunos procesos industriales, como: formulación, preformulación, purificación y cuantificación. Objetivo: Este trabajo presenta el análisis termodinámico de la solubilidad del metronidazol en mezclas de cosolventes metanol + agua y etanol + agua a siete temperaturas diferentes. Metodología: A partir de los datos de solubilidad, se calcularon y analizaron las funciones termodinámicas de la solución y la mezcla mediante el método gráfico de Perlovich. Por otro lado, se realiza un análisis de compensación entalpía-entropía y se calculan los parámetros de solvatación preferencial mediante el método de la integral inversa de Kirkwood-Buff (IKBI). Resultados: Los cálculos realizados indican que el proceso de disolución del metronidazol es endotérmico con favorecimiento entrópico, la adición de metanol y etanol tiene un efecto cosolvente positivo en mezclas intermedias y ricas en agua. En cuanto al parámetro de solvatación preferencial, los resultados no son del todo concluyentes, ya que, salvo en las mezclas intermedias, los valores del parámetro de solvatación preferencial son inferiores a 0,01, por lo que se concluye que se tiene una solvatación preferencial despreciable.

 

Introdução: A solubilidade é uma das propriedades físico-químicas mais importantes, pois está relacionada com vários processos industriais, nomeadamente formulação, préformulação, purificação e quantificação. Objetivo: O presente trabalho apresenta a análise termodinâmica da solubilidade do metronidazol em misturas de metanol + água e etanol + água em sete temperaturas diferentes. Metodologia: A partir dos dados de solubilidade, as funções termodinâmicas da solução e da mistura foram calculadas e analisadas com recurso ao método gráfico de Perlovich. Além disso, é efetuada uma análise de troca de entalpiaentropia e os parâmetros de solvatação preferenciais são calculados utilizando o método integral inverso de KirkwoodBuff (IKBI). Resultados: Os cálculos indicam que o processo de dissolução do metronidazol é endotérmico com favorecimento entrópico, e que a adição de metanol e etanol tem um efeito positivo de cosolvente em misturas intermédias e ricas em água. No que se refere ao parâmetro de solvatação preferencial, os resultados não são totalmente conclusivos, uma vez que, exceto nas misturas intermédias, os valores do parâmetro de solvatação preferencial são inferiores a 0,01, pelo que se conclui que a solvatação preferencial é desprezível.

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Cómo citar

APA

Escobar Fiesco, G. F., Caviedes-Rubio, D. I., Ortiz, C. P., Quintero Guerrero, Y., Cerquera, N. E., Rincón-Guio, C., Cardenas-Torres, R. E. & Delgado, D. R. (2025). Thermodynamic analysis and preferential solvation of metronidazole solubility in methanol-water and ethanol-water cosolvent mixtures at different temperatures. Revista Colombiana de Ciencias Químico-Farmacéuticas, 54(2), 345–363. https://doi.org/10.15446/rcciquifa.v54n2.121131

ACM

[1]
Escobar Fiesco, G.F., Caviedes-Rubio, D.I., Ortiz, C.P., Quintero Guerrero, Y., Cerquera, N.E., Rincón-Guio, C., Cardenas-Torres, R.E. y Delgado, D.R. 2025. Thermodynamic analysis and preferential solvation of metronidazole solubility in methanol-water and ethanol-water cosolvent mixtures at different temperatures. Revista Colombiana de Ciencias Químico-Farmacéuticas. 54, 2 (jul. 2025), 345–363. DOI:https://doi.org/10.15446/rcciquifa.v54n2.121131.

ACS

(1)
Escobar Fiesco, G. F.; Caviedes-Rubio, D. I.; Ortiz, C. P.; Quintero Guerrero, Y.; Cerquera, N. E.; Rincón-Guio, C.; Cardenas-Torres, R. E.; Delgado, D. R. Thermodynamic analysis and preferential solvation of metronidazole solubility in methanol-water and ethanol-water cosolvent mixtures at different temperatures. Rev. Colomb. Cienc. Quím. Farm. 2025, 54, 345-363.

ABNT

ESCOBAR FIESCO, G. F.; CAVIEDES-RUBIO, D. I.; ORTIZ, C. P.; QUINTERO GUERRERO, Y.; CERQUERA, N. E.; RINCÓN-GUIO, C.; CARDENAS-TORRES, R. E.; DELGADO, D. R. Thermodynamic analysis and preferential solvation of metronidazole solubility in methanol-water and ethanol-water cosolvent mixtures at different temperatures. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 54, n. 2, p. 345–363, 2025. DOI: 10.15446/rcciquifa.v54n2.121131. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/121131. Acesso em: 28 dic. 2025.

Chicago

Escobar Fiesco, German Fabian, Diego Ivan Caviedes-Rubio, Claudia Patricia Ortiz, Yaqueline Quintero Guerrero, Néstor Enrique Cerquera, Cristian Rincón-Guio, Rossember Edén Cardenas-Torres, y Daniel Ricardo Delgado. 2025. «Thermodynamic analysis and preferential solvation of metronidazole solubility in methanol-water and ethanol-water cosolvent mixtures at different temperatures». Revista Colombiana De Ciencias Químico-Farmacéuticas 54 (2):345-63. https://doi.org/10.15446/rcciquifa.v54n2.121131.

Harvard

Escobar Fiesco, G. F., Caviedes-Rubio, D. I., Ortiz, C. P., Quintero Guerrero, Y., Cerquera, N. E., Rincón-Guio, C., Cardenas-Torres, R. E. y Delgado, D. R. (2025) «Thermodynamic analysis and preferential solvation of metronidazole solubility in methanol-water and ethanol-water cosolvent mixtures at different temperatures», Revista Colombiana de Ciencias Químico-Farmacéuticas, 54(2), pp. 345–363. doi: 10.15446/rcciquifa.v54n2.121131.

IEEE

[1]
G. F. Escobar Fiesco, «Thermodynamic analysis and preferential solvation of metronidazole solubility in methanol-water and ethanol-water cosolvent mixtures at different temperatures», Rev. Colomb. Cienc. Quím. Farm., vol. 54, n.º 2, pp. 345–363, jul. 2025.

MLA

Escobar Fiesco, G. F., D. I. Caviedes-Rubio, C. P. Ortiz, Y. Quintero Guerrero, N. E. Cerquera, C. Rincón-Guio, R. E. Cardenas-Torres, y D. R. Delgado. «Thermodynamic analysis and preferential solvation of metronidazole solubility in methanol-water and ethanol-water cosolvent mixtures at different temperatures». Revista Colombiana de Ciencias Químico-Farmacéuticas, vol. 54, n.º 2, julio de 2025, pp. 345-63, doi:10.15446/rcciquifa.v54n2.121131.

Turabian

Escobar Fiesco, German Fabian, Diego Ivan Caviedes-Rubio, Claudia Patricia Ortiz, Yaqueline Quintero Guerrero, Néstor Enrique Cerquera, Cristian Rincón-Guio, Rossember Edén Cardenas-Torres, y Daniel Ricardo Delgado. «Thermodynamic analysis and preferential solvation of metronidazole solubility in methanol-water and ethanol-water cosolvent mixtures at different temperatures». Revista Colombiana de Ciencias Químico-Farmacéuticas 54, no. 2 (julio 8, 2025): 345–363. Accedido diciembre 28, 2025. https://revistas.unal.edu.co/index.php/rccquifa/article/view/121131.

Vancouver

1.
Escobar Fiesco GF, Caviedes-Rubio DI, Ortiz CP, Quintero Guerrero Y, Cerquera NE, Rincón-Guio C, Cardenas-Torres RE, Delgado DR. Thermodynamic analysis and preferential solvation of metronidazole solubility in methanol-water and ethanol-water cosolvent mixtures at different temperatures. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 8 de julio de 2025 [citado 28 de diciembre de 2025];54(2):345-63. Disponible en: https://revistas.unal.edu.co/index.php/rccquifa/article/view/121131

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