Publicado

2026-01-26

¿Son realmente seguros los rellenos dérmicos?

¿Are dermal fillers really safe?

Os Preenchimentos Dérmicos São Realmente Seguros?

DOI:

https://doi.org/10.15446/rcciquifa.v55n1.125089

Palabras clave:

Rellenos dérmicos, reacción a cuerpo extraño, nódulos, biopelículas (es)
Dermal fillers, foreign body reaction, nodules, biofilms (en)
Preenchimentos dérmicos, reação a corpo estranho, nódulos, biofilmes (pt)

Descargas

Autores/as

  • Laura Estela Castrillón Rivera Laboratorio de Inmunología. Departamento de Sistemas Biológicos. Universidad Autónoma Metropolitana Unidad Xochimilco, México
  • Alejandro Palma Ramos Laboratorio de Inmunología. Departamento de Sistemas Biológicos. Universidad Autónoma Metropolitana Unidad Xochimilco, México
  • Jorge Ismael Castañeda Sánchez Laboratorio de Inmunología. Departamento de Sistemas Biológicos. Universidad Autónoma Metropolitana Unidad Xochimilco, México
  • Violeta Espinosa Antúnez Laboratorio de Inmunología. Departamento de Sistemas Biológicos. Universidad Autónoma Metropolitana Unidad Xochimilco, México

Introducción: La inyección de rellenos dérmicos son procedimientos comunes en la práctica dermatológica cosmética porque son utilizados principalmente como tratamiento antienvejecimiento para corregir depresiones, arrugas, surcos, cicatrices, ángulos y flacidez entre otros. Dado que algunos rellenos dérmicos se absorben naturalmente con el tiempo, es posible que los pacientes deban repetir el procedimiento después de un período de tiempo para mantener el efecto deseado. Ya que los métodos de aplicación son mínimamente invasivos, pero como cualquier procedimiento médico, existen riesgos involucrados con su aplicación, naturaleza del material y respuesta individual del paciente, en consecuencia el uso de este tipo de rellenos tienen el potencial de producir una respuesta inflamatoria reconocida como reacción a cuerpo extraño, o presentar respuestas inmunológicas conocidas como granulomas inflamatorios que pueden cursar con complicaciones tardías en rangos de leve a severo o aún ser riesgosos para la vida. Desarrollo del tema: La presente revisión bibliográfica aborda los siguientes aspectos relacionados con: a) Clasificación de los tipos de rellenos dérmicos, b) Respuesta tisular, c) Complicaciones tempranas y tardías, d) Respuesta inmune, e) Prevención de complicaciones, f) Tratamiento y g) Perspectivas. Conclusión: La disposición de tipos y número de rellenos dérmicos continúa en aumento, por tanto, se debe entender sus riesgos y como tratar la aparición de sus complicaciones. Sin embargo, aunque se asume que los materiales utilizados son principalmente biocompatibles, existe cada vez más gran cantidad de reportes de las principales complicaciones y su tratamiento.

Introduction: Dermal filler injections are common procedures in cosmetic dermatology practice because they are used to correct depressions, wrinkles, furrows, scars, angles and sagging, among others. Since some dermal fillers are naturally absorbed over time to maintain the desired effect. Since the application methods are minimally invasive, but like any medical procedure there risks involved with the application, nature of the material and individual patient response, consequently the use of this type of fillers has the potential to produce an inflammatory response recognized as a foreign body reaction, or present immunological responses known as inflammatory granulomas that can present with late complications ranging from mild to severe or even be life-threatening. Topic development: This bibliographic review addresses the following aspects related to: a) Classification of dermal fillers types, b) Tissue response, c) Early and late complications, d) Immune response, e) Prevention of complications, f) Treatment and g) Perspectives. Conclusion: The availability of types and number of dermal fillers continues to increase, therefore, it is important to understand their risks and how to treat the appearance of their complications. However, although it is assumed that the materials used are mainly biocompatible, there are an increasing number of reports of the main complications and treatments

Introdução: As injeções de preenchimento dérmico são procedimentos comuns na dermatologia estética, sendo utilizadas principalmente como tratamento antienvelhecimento para corrigir depressões, rugas, sulcos, cicatrizes, ângulos e flacidez, entre outros problemas. Como alguns preenchimentos dérmicos são absorvidos naturalmente com o tempo, os pacientes podem precisar repetir o procedimento após um período para manter o efeito desejado. Embora os métodos de aplicação sejam minimamente invasivos, como em qualquer procedimento médico, existem riscos envolvidos na aplicação, na natureza do material e na resposta individual do paciente. Consequentemente, o uso desses tipos de preenchimentos tem o potencial de produzir uma resposta inflamatória conhecida como reação a corpo estranho, ou apresentar respostas imunológicas conhecidas como granulomas inflamatórios, que podem levar a complicações tardias que variam de leves a graves, ou mesmo serem fatais. Desenvolvimento do Tema: Esta revisão de literatura aborda os seguintes aspectos relacionados a: a) Classificação dos tipos de preenchedores dérmicos, b) Resposta tecidual, c) Complicações precoces e tardias, d) Resposta imune, e) Prevenção de complicações, f) Tratamento e g) Perspectivas. Conclusão: A disponibilidade e o número de tipos de preenchedores dérmicos continuam a aumentar; portanto, é essencial compreender seus riscos e como manejar o desenvolvimento de complicações. Contudo, embora os materiais utilizados sejam geralmente considerados biocompatíveis, há um número crescente de relatos sobre as principais complicações e seus respectivos tratamentos.

Referencias

1. A. Goldman & U. Wollina. Facial rejuvenation for middle-aged women: a combined approach with minimally invasive procedures. Clinical Interventions in Aging, 5, 293–299 (2010). URL: https://doi.org/10.2147/cia.s13215

2. FDA U.S. Food & Drug Administration. Rellenos dérmicos (rellenos de tejidos blandos) https://www.fda.gov/medical-devices/aesthetic-cosmetic-devices/dermal-fillers-soft-tissue-fillers

3. Z.-F. Liao, L.-Y. Cong, F.-W. Li, S.-W. Wang, F.-C. Liu, H.-B. Wang & S.-K. Luo. The research trend of soft tissue filler injection from 2000 to 2022: A bibliometric and visualized analysis. Plastic & Reconstructive Surgery-Global Open, 12(2), e5579 (2024). Doi: https://doi.org/10.1097/gox.0000000000005579

4. M.H. Graivier, L.M. Bass, Z.P. Lorenc, R. Fitzgerald, D.J. Goldberg & G. Lemperle. Differentiating nonpermanent injectable fillers: prevention and treatment of filler complications. Aesthetic Surgery Journal, 38(Suppl_1), S29–S40 (2018). Doi: https://doi.org/10.1093/asj/sjy032

5. I. Cheng-Flores & J.L. Moreno-González. Materiales de relleno en dermatología. Dermatología Cosmética, Médica y Quirúrgica, 9(4), 275–283 (2011). URL: https://www.medigraphic.com/pdfs/cosmetica/dcm-2011/dcm114g.pdf

6. I. Sánchez-Carpintero, D. Candelas & R. Ruiz-Rodríguez. Materiales de relleno, tipos, indicaciones y complicaciones. Actas Dermo-Sifiliográficas, 101(5), 381–393 (2010). Doi: https://doi.org/10.1016/j.ad.2010.01.004

7. D.H. Jones. Semipermanent and permanent injectable fillers. Dermatologic Clinics, 27(4), 433–444 (2009). Ddoi: https://doi.org/10.1016/j.det.2009.08.003

8. G.-W. Hong, J. Wan, K. Chang, Y. Park & K.-H. Yi. Decomposition and changes in in vivo post-HA filler injection: A review. Journal of Cosmetic Dermatology, 24(1), e16652 (2025). Doi: https://doi.org/10.1111/jocd.16652

9. A. Tezel & G.H. Fredrickson. The science of hyaluronic acid dermal fillers. Journal of Cosmetic and Laser Therapy, 16(1), 45 (2014). Doi: https://doi.org/10.1080/14764170701774901

10. M. Gold. The science and art of hyaluronic acid dermal filler use in esthetic applications. Journal of Cosmetic Dermatology, 8(4), 301–307 (2009). Doi: https://doi.org/10.1111/j.1473-2165.2009.00464.x

11. U. Wollina, H. Kocic & A. Goldman. Hyaluronic acid in facial rehabilitation—A narrative review. Cosmetics, 10(2), 61 (2023). Doi: https://doi.org/10.3390/cosmetics10020061

12. J. Alijotas-Reig M.T. Fernández-Figueras & L. Puig. Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers. Seminars in Arthritis and Rheumatism, 43(2), 241–258 (2013). Doi: https://doi.org/10.1016/j.semarthrit.2013.02.001

13. C. Faus-Alcañiz & C. Martínez-Ciarpaglini. Revisión de la respuesta tisular a los materiales de relleno. Medicina Estética, 37(4), 46–54 (2013). Doi: https://doi.org/10.48158/medicinaestetica.037.01

14. E. Haneke. Adverse effects of fillers and their histopathology. Facial Plastic Surgery, 30(6), 599–614 (2014). Doi: https://doi.org/10.1055/s-0034-1396755

15. A. Modarressi, C. Nizet & T. Lombardi. Granulomas and nongranulomatous nodules after filler injection: Different complications require different treatments. Journal of Plastic, Reconstructive & Aesthetic Surgery, 73(11), 2010–2015 (2020). Doi: https://doi.org/10.1016/j.bjps.2020.08.012

16. M.H. Abduljabbar & M.A. Basendwh. Complications of hyaluronic acid fillers and their managements. Journal of Dermatology & Dermatologic Surgery, 20(2), 100–106 (2016). Doi: https://doi.org/10.1016/j.jdds.2016.01.001

17. K. Singh & S. Nooreyezdan. Nonvascular complications of injectable fillers-Prevention and management. Indian Journal of Plastic Surgery, 53(3), 335–343 (2020). Doi: https://doi.org/10.1055/s-0040-1721872

18. K. Rentfro, D. Clarey, E.J. Glenn, R. Sulewski & A. Wysong. Soft tissue dermal filler-associated necrosis and impending necrosis: A systematic review of the literature. Dermatologic Surgery, 48(10), 1051–1056 (2022). Doi: https://doi.org/10.1097/dss.0000000000003574

19. R.A. Machado, L.Q. Rocha de Oliveira, H. Martelli-Júnior, Fábio Ramoa-Pires, J. Badin-Carvas, V.E. Rogerio, V. de Azevedo-Rabelo & R.D. Coletta. Adverse reactions to the injection of face and neck aesthetic filling materials: a systematic review. Medicina Oral, Patología Oral y Cirugía Bucal, 28(3), e278–e284 (2020). Doi: https://doi.org/10.4317/medoral.25713

20. C. DeLorenzi. Complications of injectable fillers, Part 2: Vascular complications. Aesthetic Surgery Journal, 34(4), 584–600 (2014). Doi: https://doi.org/10.1177/1090820x14525035

21. L. Requena, C. Requena, L. Christensen, U.S. Zimmermann, H. Kutzner & L. Cerroni. Adverse reactions to injectable soft tissue fillers. Journal of the American Academy of Dermatology, 64(6), 1178 (2011). Doi: https://doi.org/10.1016/j.jaad.2010.02.064

22. D. Funt & T. Pavicic. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clinical, Cosmetic and Investigational Dermatology, 2013(6), 295–316 (2013). Doi: https://doi.org/10.2147/ccid.s50546

23. F. Bachmann, R. Erdmann, V. Hartmann, L. Wiest & B. Rzany. The spectrum of adverse reactions after treatment with injectable fillers in the glabellar region: results from the Injectable Filler Safety Study. Dermatologic Surgery, 35(Suppl 2), 1629–1634 (2009). Doi: https://doi.org/10.1111/j.1524-4725.2009.01341.x

24. C. DeLorenzi. Complications of injectable fillers, part I. Aesthetic Surgery Journal, 33(4), 561–575 (2013). Doi: https://doi.org/10.1177/1090820x13484492

25. S.H. Dayan, J.P. Arkins & R. Brindise. Soft tissue fillers and biofilms. Facial Plastic Surgery, 27(1), 23–28 (2011). Doi: https://doi.org/10.1055/s-0030-1270415

26. M. Brandwein, D. Steinberg & S. Meshner. Microbial biofilms and the human skin microbiome. NPJ Biofilms and Microbiomes, 2, 3 (2016). Doi: https://doi.org/10.1038/s41522-016-0004-z

27. A.V. Gannesen, V. Borrel, L. Lefeuvre, A.I. Netrusov, V.K. Plakunov & M.G.J. Feuilloley. Effect of two cosmetic compounds on the growth, biofilm formation activity, and surface properties of acneic strains of Cutibacterium acnes and Staphylococcus aureus. Microbiology Open, 8(3), e00659 (2019). Doi: https://doi.org/10.1002/mbo3.659

28. T. Coenye, K.J. Spittaels & Y. Achermann. The role of biofilm formation in the pathogenesis and antimicrobial susceptibility of Cutibacteriumacnes. Biofilm, 4, 100063 (2021). Doi: https://doi.org/10.1016/j.bioflm.2021.100063

29. L.N. Trinh, K.C. McGuigan & A. Gupta. Delayed granulomas as a complication secondary to lip augmentation with dermal fillers: A systematic review. The Surgery Journal, 8(1), e69–e79 (2022). Doi: https://doi.org/10.1055/s-0042-1743524

30. C. Convery, E. Davies, G. Murray & L. Walker. Delayed-onset nodules (DONs) and considering their treatment following use of hyaluronic acid (HA) fillers. The Journal of Clinical and Aesthetic Dermatology, 14(7), E59–E67 (2021). URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC8570356/

31. M.A. Izquierdo & L. Requena. Granulomas por cuerpos extraños. Actas Dermo-Sifiliográficas, 90(11), 543–557 (1999). URL: https://www.actasdermo.org/es-granulomas-por-cuerpos-extranos--articulo13003554

32. J. Aróstegui-Aguilar, A. Diago, R. Carrillo-Gijón, M. Fernández-Figueras, J. Fraga, A. García-Herrera, et al. Granulomas en dermatopatología: principales entidades. Parte II. Actas Dermo-Sifiliográficas, 112(8), 705–724 (2021). Doi: https://doi.org/10.1016/j.ad.2021.04.001

33. J.M. Lee & Y.J. Kim. Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment. Archives of Plastic Surgery, 42(2), 232–239 (2015). Doi: https://doi.org/10.5999/aps.2015.42.2.232

34. S.-K. Lee, S.M. Kim, S.H. Cho, J.D. Lee & H.S. Kim HS. Adverse reactions to injectable soft tissue fillers: memorable cases and their clinico-pathological overview. Journal of Cosmetic and Laser Therapy, 17(2), 102–108 (2015). Doi: https://doi.org/10.3109/14764172.2014.968584

35. G. Lemperle, N. Gauthier-Hazan, M. Wolters, M. Eisemann-Klein, U. Zimmermann U & D.M. Duffy. Foreign body granulomas after all injectable dermal fillers: Part 1. Possible causes. Plastic and Reconstructive Surgery, 123(6), 1842–1863 (2009). Doi: https://doi.org/10.1097/prs.0b013e31818236d7

36. S. Sharma, J. Mohler, S.D. Mahajan, S.A. Schwartz, L. Bruggemann & R. Aalinkeel. Microbial biofilm: A review on formation, infection, antibiotic resistance, control measures, and innovative treatment. Microorganisms, 11(6), 1614 (2023). Doi: https://doi.org/10.3390/microorganisms11061614

37. A.B. Sadashivaiah & V. Mysore. Biofilms: their role in dermal fillers. Journal of Cutaneous and Aesthetic Surgery, 3(1), 20–22 (2010). Doi: https://doi.org/10.4103/0974-2077.63257

38. Y.L. Zhang, Z.S. Sun, W.J. Hong, Y. Chen, Y.F. Zhou & S.K. Luo. Biofilm formation is a risk factor for late and delayed complications of filler injection. Frontiers in Microbiology, 14, 1297948 (2024). Doi: https://doi.org/10.3389/fmicb.2023.1297948

39. M.T. Imen. Delayed infectious reactions of dermal filler injections in the face: Causes and management. Journal of Stomatology, Oral and Maxillofacial Surgery, 124(2), 101334 (2023). Doi: https://doi.org/10.1016/j.jormas.2022.11.010

40. M. Saththianathan, K. Johani, A. Taylor, H. Hu, K. Vickery, P. Callan & A.K. Deva. The role of bacterial biofilm in adverse soft-tissue filler reactions: A combined laboratory and clinical study. Plastic Reconstructive Surgery, 139(3), 613–621 (2017). Doi: https://doi.org/10.1097/prs.0000000000003067

41. A. Hassan, J. Usman, F. Kaleem, M. Omair, A. Khalid & M. Iqbal. Evaluation of different detection methods of biofilm formation in the clinical isolates. The Brazilian Journal of Infectious Diseases, 15(4), 305–311 (2011). Doi : https://doi.org/10.1016/S1413-8670(11)70197-0

42. Y. Xu, Y. Dhaouadi, P. Stoodley & D. Ren. Sensing the unreachable: challenges and opportunities in biofilm detection. Current Opinion in Biotechnology, 64, 79–84 (2020). Doi: https://doi.org/10.1016/j.copbio.2019.10.009

43. K. Conrad, R. Alipasha, S. Thiru & T. Kandasamy. Abscess formation as a complication of injectable fillers. Modern Plastic Surgery, 5, 14–18 (2015). Doi: https://doi.org/10.4236/mps.2015.52003

44. L. Gottfried. No proof that biofilm bacteria are causing dermal filler granulomas. American Journal of Biomedical Science & Research, 4(1), 17–22 (2019). Doi: https://doi.org/10.34297/ajbsr.2019.04.000749

45. V.J. Hassid. Soft-tissue filler complications: the important role of biofilms. Plastic Reconstructive Surgery, 126(5), 1801–1802 (2010). Doi: https://doi.org/10.1097/prs.0b013e3181ef93b5

46. R.J. Rohrich, G. Monheit, A.T. Nguyen, S.A. Brown & S. Fagien. Soft-tissue filler complications: the important role of biofilms. Plastic Reconstructive Surgery, 125(4), 1250–1256 (2010). Doi: https://doi.org/10.1097/prs.0b013e3181cb4620

47. M. Alhede, Ö. Er, S. Eickhardt, K. Kragh, M. Alhede, L.D. Christensen, et al. Bacterial biofilm formation and treatment in soft tissue fillers. Pathogens and Disease, 70(3), 339–346 (2014). Doi: https://doi.org/10.1111/2049-632x.12139

48. K. Beer & R. Avelar. Relationship between delayed reactions to dermal fillers and biofilms: facts and considerations. Dermatologic Surgery, 40(11), 1175–1179 (2014). Doi: https://doi.org/10.1097/01.dss.0000452646.76270.53

49. M.M. Draelos & Z.D. Draelos. The biofilm, injectables, and cosmetic dermatology. Journal of Cosmetic Dermatology, 12(4), 245–246 (2013). Doi: https://doi.org/10.1111/jocd.12069

50. N. Doshi & S. Mitragotri. Macrophages recognize size and shape of their targets. PLoS One, 5(4), e10051 (2010). Doi: https://doi.org/10.1371/journal.pone.0010051

51. C.K. Hee & D.J. Messina. In vitro inflammatory and immune response to uncrosslinked hyaluronic acid (HA) and HA fillers. Journal of Immunology and Regenerative Medicine, 17, 100065 (2022). Doi: https://doi.org/10.1016/j.regen.2022.100065

52. J.M. Cyphert, C.S. Trempus & S. Garantziotis. Size matters: Molecular weight specificity of hyaluronan effects in cell biology. International Journal of Cell Biology, 2015, 563818 (2015). Doi: https://doi.org/10.1155/2015/563818

53. X. Jia, M. Shi, Q. Wang, J. Hui, J.H. Shofaro, R. Erkhembayar, M. Hui, C. Gao & M.A. Gantumur. Anti-inflammatory effects of the 35kDa hyaluronic acid fragment (B-HA/HA35). Journal of Inflammation Research, 16, 209–224 (2023). Doi: https://doi.org/10.2147/jir.s393495

54. A. Owczarczyk-Saczonek, N. Zdanowska, E. Wygonowska & W. Placek. The immunogenicity of hyaluronic fillers and its consequences. Clinical, Cosmetic and Investigational Dermatology, 14, 921–934 (2021). Doi: https://doi.org/10.2147/ccid.s316352

55. A. Owczarczyk-Saczonek & K. De Boulle. Hyaluronic acid fillers and ASIA syndrome: Case studies. Clinical, Cosmetic and Investigational Dermatology, 16, 2763—2771 (2023). Doi: https://doi.org/10.2147/ccid.s419716

56. H. Witmanowski & K. Błochowiak. Another face of dermal fillers. Advances in Dermatology and Allergology, 37(5), 651–659 (2020). Doi: https://doi.org/10.5114/ada.2019.82859

57. I. Heydenrych, K. De Boulle, K.M. Kapoor & D. Bertossi. The 10-Point Plan 2021: Updated concepts for improved procedural safety during facial filler treatments. Clinical, Cosmetic and Investigational Dermatology, 14, 1601–1602 (2021). Doi: https://doi.org/10.2147/ccid.s346299

58. S.G. Fabi, S. Desyatnikova & S.H. Dayan. Prevention and management of dermal filler complications: A review. Facial Plastic Surgery & Aesthetic Medicine, 27(2), 120–124 (2024). Doi: https://doi.org/10.1089/fpsam.2024.0020

59. M. de Maio. MD Codes™: A methodological approach to facial aesthetic treatment with injectable hyaluronic acid fillers. Aesthetic Plastic Surgery, 45(2), 690–709 (2021). Doi: https://doi.org/10.1007/s00266-020-01762-7

60. Z. Diwan, S. Trikha, S. Etemad-Shahidi, S. Virmani, C. Denning, Y. Al-Mukhtar, C. Rennie, A. Penny, Y. Jamali & N.C. Edwards-Parrish. Case series and review on managing abscesses secondary to hyaluronic acid soft tissue fillers with recommended management guidelines. The Journal of Clinical and Aesthetic Dermatology, 13(11), 37–43 (2020). URL: https://pubmed.ncbi.nlm.nih.gov/33282102/

61. N. Corduff, L. Juniarti, T.S. Lim, F. Lin, K. Mariwalla, T. Pavicic, et al. Current practices in hyaluronic acid dermal filler treatment in Asia Pacific and practical approaches to achieving safe and natural-looking results. Clinical, Cosmetic and Investigational Dermatology, 15, 1213–1223 (2022). Doi: https://doi.org/10.2147/ccid.s363583

62. D.K. Funt. Treatment of delayed-onset inflammatory reactions to hyaluronic acid filler: An algorithmic approach. Plastic and Reconstructive Surgery - Global Open, 10(6), e4362 (2022). Doi: https://doi.org/10.1097/gox.0000000000004362

63. M.R. Taha & S.K. Tyring. A review of the role and treatment of biofilms in skin disorders. Skin Therapy Letters, 29(6), 6-9 (2024). URL: https://www.skintherapyletter.com/acne/treatment-of-biofilms-in-skin-disorders/

64. X. Kang, X. Yang, Y. He, C. Guo, Y. Li, H. Ji, Y. Qin & L. Wu. Strategies and materials for the prevention and treatment of biofilms. Materials Today Bio, 23, 100827 (2023). Doi: https://doi.org/10.1016/j.mtbio.2023.100827

65. D.I. Dumitraşcu & A.V. Georgescu. The management of biofilm formation after hyaluronic acid gel filler injections: a review. Clujul Medical, 86(3), 192–195 (2013). URL: https://pubmed.ncbi.nlm.nih.gov/26527945/

66. A.-G. Nicola, M.O. Pricop & B. Ramos-Medina. Clinical management with high-frequency ultrasound of recurrent submental abscess formation after filler placement: Bacterial contamination or immune-mediated adverse event? Cureus, 16(4), e58878 (2024). Doi: https://doi.org/10.7759/cureus.58878

67. S.J. Almushayt. The role of ultrasound in facial hyaluronic acid dermal filler injections - A review article. Clinical Imaging, 119, 110413 (2025). Doi: https://doi.org/10.1016/j.clinimag.2025.110413

68. M. Kamei. Treatments for central retinal vein occlusion. There is no established standard of care for CRVO. Anti-VEGF therapy may become a first-line choice in the near future. Retina Today, Jan/Feb 2013, 34-36 (2013). URL: https://retinatoday.com/articles/2013-jan/treatments-for-centralretinal-vein-occlusion https://assets.bmctoday.net/retinatoday/pdfs/0113RT_Global%20Perspectives.pdf

69. B.S. Biesman, J.B. Green, R. George, C. Jacob, M. Palm, D.H. Jones, et al. A multicenter, randomized, evaluator-blinded study to examine the safety and effectiveness of hyaluronic acid filler in the correction of infraorbital hollows. Aesthetic Surgery Journal, 44(9), 1001–1013 (2024). Doi: https://doi.org/10.1093/asj/sjae073

70. N. Fakih-Gomez, C. Muñoz-Gonzalez, C.A. Porcar-Plana, M. Puzo-Bayod & J. Madero. Retrobulbar hyaluronidase in hyaluronic acid-induced ocular vascular occlusion: Efficacy, challenges, and implications for clinical practice. Aesthetic Plastic Surgery, 49(5), 1458–1468 (2025). Doi: https://doi.org/10.1007/s00266-024-04483-3

71. M. Signorini, S. Liew, H. Sundaram, K.L. De Boulle, G.J. Goodman, G. Monheit, Y. Wu, A.R. Trindade de Almeida, A. Swift & A. Vieira-Braz. Global Aesthetics Consensus: Avoidance and management of complications from hyaluronic acid fillers-evidence- and opinion-based review and consensus recommendations. Plastic and Reconstructive Surgery, 137(6), 961e–971e (2016). Doi: https://doi.org/10.1097/prs.0000000000002184

72. G. Zaccaria, A. Dotti, E. Benanti, C. Vigliarolo & L. Vaienti. A treatment algorithm for hyaluronic acid filler related complications of the face. Journal of Plastic, Reconstructive & Aesthetic Surgery, 91, 207–217 (2024). Doi: https://doi.org/10.1016/j.bjps.2024.02.010

73. O. Artzi, J.L. Cohen, J.S. Dover, A. Suwanchinda, T. Pavicic, M. Landau, et al. Delayed inflammatory reactions to hyaluronic acid fillers: A literature review and proposed treatment algorithm. Clinical, Cosmetic and Investigational Dermatology, 18(13), 371–378 (2020). Doi: https://doi.org/10.2147/ccid.s247171

74. F. Urdiales-Gálvez, N.E. Delgado, V. Figueiredo, J.V. Lajo-Plaza, M. Mira, A. Moreno, et al. Treatment of soft tissue filler complications: Expert consensus recommendations. Aesthetic Plastic Surgery, 42(2), 498–510 (2018). Doi: https://doi.org/10.1007/s00266-017-1063-0

75. W. Baranska-Rybak, J.V. Lajo-Plaza, L. Walker & N. Alizadeh. Late-Onset Reactions after Hyaluronic Acid Dermal Fillers: A consensus recommendation on etiology, prevention and management. Dermatology and Therapy (Heidelberg), 14(7), 1767–1785 (2024). Doi: https://doi.org/10.1007/s13555-024-01202-3

76. Z. Diwan, S. Trikha, S. Etemad-Shahidi, N. Parrish & C. Rennie. Evaluation of current literature on complications secondary to lip augmentation following dermal filler injection. The Journal of Clinical and Aesthetic Dermatology, 16(7), 26–33 (2023). URL : https://pubmed.ncbi.nlm.nih.gov/37560504/

77. M. Coppini, V.C.A. Caponio, R. Mauceri, G. Pizzo, N. Mauceri, L. Lo Muzio & G. Campisi. Aesthetic lip filler augmentation is not free of adverse reactions: lack of evidence-based practice from a systematic review. Frontiers in Oral Health, 5, 1495012 (2024). Doi: https://doi.org/10.3389/froh.2024.1495012

Cómo citar

APA

Castrillón Rivera, L. E., Palma Ramos, A., Castañeda Sánchez, J. I. & Espinosa Antúnez, V. (2026). ¿Son realmente seguros los rellenos dérmicos?. Revista Colombiana de Ciencias Químico-Farmacéuticas, 55(1), 195–214. https://doi.org/10.15446/rcciquifa.v55n1.125089

ACM

[1]
Castrillón Rivera, L.E., Palma Ramos, A., Castañeda Sánchez, J.I. y Espinosa Antúnez, V. 2026. ¿Son realmente seguros los rellenos dérmicos?. Revista Colombiana de Ciencias Químico-Farmacéuticas. 55, 1 (ene. 2026), 195–214. DOI:https://doi.org/10.15446/rcciquifa.v55n1.125089.

ACS

(1)
Castrillón Rivera, L. E.; Palma Ramos, A.; Castañeda Sánchez, J. I.; Espinosa Antúnez, V. ¿Son realmente seguros los rellenos dérmicos?. Rev. Colomb. Cienc. Quím. Farm. 2026, 55, 195-214.

ABNT

CASTRILLÓN RIVERA, L. E.; PALMA RAMOS, A.; CASTAÑEDA SÁNCHEZ, J. I.; ESPINOSA ANTÚNEZ, V. ¿Son realmente seguros los rellenos dérmicos?. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 55, n. 1, p. 195–214, 2026. DOI: 10.15446/rcciquifa.v55n1.125089. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/125089. Acesso em: 30 ene. 2026.

Chicago

Castrillón Rivera, Laura Estela, Alejandro Palma Ramos, Jorge Ismael Castañeda Sánchez, y Violeta Espinosa Antúnez. 2026. «¿Son realmente seguros los rellenos dérmicos?». Revista Colombiana De Ciencias Químico-Farmacéuticas 55 (1):195-214. https://doi.org/10.15446/rcciquifa.v55n1.125089.

Harvard

Castrillón Rivera, L. E., Palma Ramos, A., Castañeda Sánchez, J. I. y Espinosa Antúnez, V. (2026) «¿Son realmente seguros los rellenos dérmicos?», Revista Colombiana de Ciencias Químico-Farmacéuticas, 55(1), pp. 195–214. doi: 10.15446/rcciquifa.v55n1.125089.

IEEE

[1]
L. E. Castrillón Rivera, A. Palma Ramos, J. I. Castañeda Sánchez, y V. Espinosa Antúnez, «¿Son realmente seguros los rellenos dérmicos?», Rev. Colomb. Cienc. Quím. Farm., vol. 55, n.º 1, pp. 195–214, ene. 2026.

MLA

Castrillón Rivera, L. E., A. Palma Ramos, J. I. Castañeda Sánchez, y V. Espinosa Antúnez. «¿Son realmente seguros los rellenos dérmicos?». Revista Colombiana de Ciencias Químico-Farmacéuticas, vol. 55, n.º 1, enero de 2026, pp. 195-14, doi:10.15446/rcciquifa.v55n1.125089.

Turabian

Castrillón Rivera, Laura Estela, Alejandro Palma Ramos, Jorge Ismael Castañeda Sánchez, y Violeta Espinosa Antúnez. «¿Son realmente seguros los rellenos dérmicos?». Revista Colombiana de Ciencias Químico-Farmacéuticas 55, no. 1 (enero 26, 2026): 195–214. Accedido enero 30, 2026. https://revistas.unal.edu.co/index.php/rccquifa/article/view/125089.

Vancouver

1.
Castrillón Rivera LE, Palma Ramos A, Castañeda Sánchez JI, Espinosa Antúnez V. ¿Son realmente seguros los rellenos dérmicos?. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 26 de enero de 2026 [citado 30 de enero de 2026];55(1):195-214. Disponible en: https://revistas.unal.edu.co/index.php/rccquifa/article/view/125089

Descargar cita

CrossRef Cited-by

CrossRef citations0

Dimensions

PlumX

Visitas a la página del resumen del artículo

17

Descargas

Los datos de descargas todavía no están disponibles.