Publicado

2015-09-01

Novel gel-like microemulsion for topical delivery of Amphotericin B

Autores/as

  • Claudia Salerno
  • Susana Gorzalczany
  • Alicia Arechavala
  • Silvia L. Scioscia
  • Adriana M. Carlucci
  • Carlos Bregni

The aim of the present work was to develop a ME for topical delivery of Amphotericin B (AmB). Microemulsions (MEs) are versatile systems to solubilize drugs due to the presence of both a hydrophobic and a hydrophilic region, as well as a distinctive interface composed of surfactant and cosurfactant. MEs have been reported for many advantages for topical application of drugs. Considering that AmB has very low water solubility a screening of surfactants and oils was performed. A gel-like ME system, that can be applied topically without the need for thickeners agents, was selected. AmB was incorporated up to 1 mg/g and remained stable for at least 90 days both at 4 ºC and room temperature, so this formulation would be appropriate as a compounding medication. An in vitro skin penetration test was performed, the applied dose penetrated (10.16 ± 0.01 μg/cm2/h as estimated flux) and remained completely within the skin during the assay; AmB was not detected in the receptor
compartment. In vitro antifungal and antileishmanial activity was tested and drug showed proper activity. AmB is a second line drug for the treatment of cutaneous leishmaniasis, but topical dosage forms are still lacking. This system is potentially useful for the treatment of skin infections avoiding drug toxic systemic effects.

Cómo citar

APA

Salerno, C., Gorzalczany, S., Arechavala, A., Scioscia, S. L., Carlucci, A. M., & Bregni, C. (2015). Novel gel-like microemulsion for topical delivery of Amphotericin B. Revista Colombiana De Ciencias Químico-Farmacéuticas, 44(3), 359–381. https://doi.org/10.15446/rcciquifa.v44n3.56285

ACM

[1]
Salerno, C., Gorzalczany, S., Arechavala, A., Scioscia, S.L., Carlucci, A.M. y Bregni, C. 2015. Novel gel-like microemulsion for topical delivery of Amphotericin B. Revista Colombiana de Ciencias Químico-Farmacéuticas. 44, 3 (sep. 2015), 359–381. DOI:https://doi.org/10.15446/rcciquifa.v44n3.56285.

ACS

(1)
Salerno, C.; Gorzalczany, S.; Arechavala, A.; Scioscia, S. L.; Carlucci, A. M.; Bregni, C. Novel Gel-Like Microemulsion for Topical Delivery of Amphotericin B. Rev. Colomb. Cienc. Quím. Farm. 2015, 44, 359-381.

ABNT

SALERNO, C.; GORZALCZANY, S.; ARECHAVALA, A.; SCIOSCIA, S. L.; CARLUCCI, A. M.; BREGNI, C. Novel gel-like microemulsion for topical delivery of Amphotericin B. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 44, n. 3, p. 359–381, 2015. DOI: 10.15446/rcciquifa.v44n3.56285. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/56285. Acesso em: 26 ene. 2023.

Chicago

Salerno, Claudia, Susana Gorzalczany, Alicia Arechavala, Silvia L. Scioscia, Adriana M. Carlucci, y Carlos Bregni. 2015. «Novel Gel-Like Microemulsion for Topical Delivery of Amphotericin B». Revista Colombiana De Ciencias Químico-Farmacéuticas 44 (3):359-81. https://doi.org/10.15446/rcciquifa.v44n3.56285.

Harvard

Salerno, C., Gorzalczany, S., Arechavala, A., Scioscia, S. L., Carlucci, A. M. y Bregni, C. (2015) «Novel gel-like microemulsion for topical delivery of Amphotericin B», Revista Colombiana de Ciencias Químico-Farmacéuticas, 44(3), pp. 359–381. doi: 10.15446/rcciquifa.v44n3.56285.

IEEE

[1]
C. Salerno, S. Gorzalczany, A. Arechavala, S. L. Scioscia, A. M. Carlucci, y C. Bregni, «Novel gel-like microemulsion for topical delivery of Amphotericin B», Rev. Colomb. Cienc. Quím. Farm., vol. 44, n.º 3, pp. 359–381, sep. 2015.

MLA

Salerno, C., S. Gorzalczany, A. Arechavala, S. L. Scioscia, A. M. Carlucci, y C. Bregni. «Novel Gel-Like Microemulsion for Topical Delivery of Amphotericin B». Revista Colombiana De Ciencias Químico-Farmacéuticas, vol. 44, n.º 3, septiembre de 2015, pp. 359-81, doi:10.15446/rcciquifa.v44n3.56285.

Turabian

Salerno, Claudia, Susana Gorzalczany, Alicia Arechavala, Silvia L. Scioscia, Adriana M. Carlucci, y Carlos Bregni. «Novel Gel-Like Microemulsion for Topical Delivery of Amphotericin B». Revista Colombiana de Ciencias Químico-Farmacéuticas 44, no. 3 (septiembre 1, 2015): 359–381. Accedido enero 26, 2023. https://revistas.unal.edu.co/index.php/rccquifa/article/view/56285.

Vancouver

1.
Salerno C, Gorzalczany S, Arechavala A, Scioscia SL, Carlucci AM, Bregni C. Novel gel-like microemulsion for topical delivery of Amphotericin B. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 1 de septiembre de 2015 [citado 26 de enero de 2023];44(3):359-81. Disponible en: https://revistas.unal.edu.co/index.php/rccquifa/article/view/56285

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CrossRef citations2

1. Umar Farooq, Akhtar Rasul, Muhammad Zafarullah, Ghulam Abbas, Maria Rasool, Farman Ali, Shabbir Ahmed, Zeeshan Javaid, Zoya Abid, Humayun Riaz, Rana Khalid Mahmood Arshad, Shayan Maryam, Naseem Amna, Kanwal Asif. (2021). Nanoemulsions as novel nanocarrieres for drug delivery across the skin: In-vitro, in-vivo evaluation of miconazole nanoemulsions for treatment of Candidiasis albicans. Designed Monomers and Polymers, 24(1), p.240. https://doi.org/10.1080/15685551.2021.1965724.

2. Kuldeep Rajpoot, Rakesh K. Tekade. (2019). Drug Delivery Systems. , p.455. https://doi.org/10.1016/B978-0-12-814487-9.00010-7.


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