Publicado

2017-01-01

Synthesis, characterization and in vitro antimicrobial screening studies of some pyridyl-coumarin compounds

Síntesis, caracterización y evaluación antimicrobiana in vitro de algunos derivados de piridil-coumarina

Palabras clave:

Pyridyl-coumarin compounds, Gram positive bacteria, Gram negative bacteria, fungal strains, DMF, DMSO (en)
Derivados de piridil-cumarina, bacterias Gram positivas, bacterias Gram negativas, cepas fúngicas, DMF, DMSO (es)

Autores/as

  • Shipra Baluja Department of Chemistry, Saurashtra University, Rajkot-360005 (Gujarat)
  • Sumitra Chanda Department of Chemistry, Saurashtra University, Rajkot-360005 (Gujarat)
  • Hemali Padalia Department of Chemistry, Saurashtra University, Rajkot-360005 (Gujarat)
  • Rahul Talaviya Department of Chemistry, Saurashtra University, Rajkot-360005 (Gujarat)
In vitro antimicrobial screening of some pyridyl-coumarin compounds were done against some bacterial and fungal strains in DMF and DMSO. These pyridyl-coumarin compounds were synthesized in the laboratory and their structure wasconfirmed by different spectroscopic techniques such as IR, 1H NMR, 13C NMR and mass. Some of these compounds exhibited excellent antibacterial activity in both the solvents

La actividad antimicrobiana in vitro de algunos compuestos derivados de piridil-coumarina se evaluó frente a algunas cepas bacterianas y fúngicas en DMF y DMSO. Las piridil-cumarinas se sintetizaron en el laboratorio y sus estructuras se confirmaron por diferentes técnicas espectroscópicas, tales como IR, 1H NMR, 13C NMR y masas. Algunos de los compuestos que se obtuvieron presentaron buena actividad antibacteriana en ambos solventes. 

Descargas

Los datos de descargas todavía no están disponibles.

Citas

(1) A.L. Demain, S. Sanchez, Microbial drug discovery: 80 years of progress (review

article), J. Antibiotics, 62, 5 (2009).

(2) U. Kalidhar, A. Kaur, An overview on some benzimidazole and sulphonamide

derivatives with anti-microbial activity, Res. J. Pharm. Biol. Chem. Sci., 2, 1116

(2011).

(3) R.J. Fair, Y. Tor, Antibiotics and bacterial resistance in the 21st century, Perspect

Med. Chem., 6, 25 (2014).

(4) S.B. Singh, Confronting the challenges of discovery of novel antibacterial agents,

Bioorg. Med. Chem. Lett., 24, 3683 (2014).

(5) S.S. Kanj, Z.A. Kanafani, Current concept in antimicrobial therapy against

resistant Gram negative organisms: extended spectrum ß-lactamase producing

enterobacteriaceae, carbapenem resistant enterobacteriaceae and multidrug

resistant Pseudomonus aeruginosa, Mayo Clin. Proc., 86, 250 (2011).

(6) N.C. Desai, H.M. Satodiya, K.M. Rajpara, V.V. Joshi, H.V. Vaghani, Microwave

assisted synthesis of new coumarin based 3-cyanopyridine scaffolds bearing sulphonamide

group having antimicrobial activity, Ind. J. Chem., 52B, 904 (2013).

(7) J. Sahoo, S.K. Mekap, P.S. Kumar, Synthesis, spectral characterization of some

new 3-heteroaryl azo 4-hydroxy coumarin derivatives and their antimicrobial

evaluation, J. Taibuh Uni. Sci., 9, 187 (2015).

(8) D.R. Buckie, D.J. Outred, H. Smith, B.A. Spicer, N-benzylpiperazino derivatives

of 3-nitro-4-hydroxycoumarin with H1 antihistamine and mast cell stabilizing

properties, J. Med. Chem., 27, 1452 (1984).

(9) T. Nasr, S. Bondock, M. Youns, Anticancer activity of new coumarin substituted

hydrazide-hydrazone derivatives, Eur. J. Med. Chem., 76, 539 (2014).

(10) A.A. Al-Amiery, A.A.H. Kadhum, A.B. Mohamad, Antifungal activities of new

coumarins, Molecules, 17, 5713 (2012).

(11) B.S. Jayashree, S. Nigam, A. Pai, P.V.R. Chowdary, Overview on the recently

developed coumarinyl heterocycles as useful therapeutic agents, Arabian J.

Chem., 7, 885 (2014).

(12) A. Manvar, A. Malde, J. Verma, V. Virsodia, A. Mishra, K. Upadhyay, H. Achrya,

E. Coutinho, A. Shah, Synthesis anti-tubercular active and 3D QSAR study

of coumarin-4-acetic acid benzylidene hydrazides, Eur. J. Med. Chem., 43, 2395

(2008).

(13) R.K. Arora, N. Kaur, Y. Bansal, G. Bansal, Novel coumarin-benzimidazole derivatives

as antioxidant and safer anti-inflammatory agent, Acta Pharm. Sinica B, 4,

(2014).

(14) J. Sahoo, S.K. Mekap, P.S. Kumar, Synthesis, spectral characterization of some

new 3-heteroaryl azo 4-hydroxy coumarin derivatives and their antimicrobial

evaluation, J. Taibah Univ. Sci., 9, 187 (2015).

(15) D. Yu. M. Suzuki, L. Xie, S. L. Morris-Natschke, K. H. Lee, Recent progress in

the development of coumarin derivatives as potent anti-HIV agent, Med. Res.

Rev., 23, 322 (2003).

(16) U.C. Mashelkar, S. S. Tungare, S. Bhagat, Studies on synthesis of various N-substituted

derivatives with different heterocycles and their herbicidal activity, Ind.

J. Chem., 50B, 315 (2011).

(17) P.A. Vadola, D. Sames, Catalytic coupling of arene C-H bonds and alkynes for

the synthesis of coumarins: substrate scope and application to the development

of neuroimaging agents, J. Org. Chem., 77, 7804 (2012).

(18) R. Rajagopal, V.U. Shenoy, S. Padmanabhan, S. Sequeria, S. Seshadri, Synthesis

of fluorescent 2,3-fused coumarin derivatives, Dyes Pigments, 13, 167 (1990).

(19) R. Sanchez-de-Armas, M.A.S. Miguel, J. Oviedo, J.F. Sanz, Coumarin derivatives

for dye sensitized solar cells: a TD-DFT study, Phys. Chem. Chem. Phys., 14,

, (2012).

(20) J.A. Riddick, W.B. Bunger, T. Sakano, “Organic solvents-physical properties

and methods of purification, techniques of Chemistry”, II, A Wiley-Interscience

Publication, John Wiley, New York, 1986.

(21) J. Parekh, P. Inamdar, R. Nair, S. Baluja, S. Chanda, Synthesis and antibacterial

activity of some Schiff bases derived from 4-aminobenzoic acid, J. Serb. Chem.

Soc., 70, 1155 (2005).