Synthesis, characterization and in vitro antimicrobial screening studies of some pyridyl-coumarin compounds
Síntesis, caracterización y evaluación antimicrobiana in vitro de algunos derivados de piridil-coumarina
Palabras clave:
Pyridyl-coumarin compounds, Gram positive bacteria, Gram negative bacteria, fungal strains, DMF, DMSO (en)Derivados de piridil-cumarina, bacterias Gram positivas, bacterias Gram negativas, cepas fúngicas, DMF, DMSO (es)
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La actividad antimicrobiana in vitro de algunos compuestos derivados de piridil-coumarina se evaluó frente a algunas cepas bacterianas y fúngicas en DMF y DMSO. Las piridil-cumarinas se sintetizaron en el laboratorio y sus estructuras se confirmaron por diferentes técnicas espectroscópicas, tales como IR, 1H NMR, 13C NMR y masas. Algunos de los compuestos que se obtuvieron presentaron buena actividad antibacteriana en ambos solventes.
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(1) A.L. Demain, S. Sanchez, Microbial drug discovery: 80 years of progress (review
article), J. Antibiotics, 62, 5 (2009).
(2) U. Kalidhar, A. Kaur, An overview on some benzimidazole and sulphonamide
derivatives with anti-microbial activity, Res. J. Pharm. Biol. Chem. Sci., 2, 1116
(2011).
(3) R.J. Fair, Y. Tor, Antibiotics and bacterial resistance in the 21st century, Perspect
Med. Chem., 6, 25 (2014).
(4) S.B. Singh, Confronting the challenges of discovery of novel antibacterial agents,
Bioorg. Med. Chem. Lett., 24, 3683 (2014).
(5) S.S. Kanj, Z.A. Kanafani, Current concept in antimicrobial therapy against
resistant Gram negative organisms: extended spectrum ß-lactamase producing
enterobacteriaceae, carbapenem resistant enterobacteriaceae and multidrug
resistant Pseudomonus aeruginosa, Mayo Clin. Proc., 86, 250 (2011).
(6) N.C. Desai, H.M. Satodiya, K.M. Rajpara, V.V. Joshi, H.V. Vaghani, Microwave
assisted synthesis of new coumarin based 3-cyanopyridine scaffolds bearing sulphonamide
group having antimicrobial activity, Ind. J. Chem., 52B, 904 (2013).
(7) J. Sahoo, S.K. Mekap, P.S. Kumar, Synthesis, spectral characterization of some
new 3-heteroaryl azo 4-hydroxy coumarin derivatives and their antimicrobial
evaluation, J. Taibuh Uni. Sci., 9, 187 (2015).
(8) D.R. Buckie, D.J. Outred, H. Smith, B.A. Spicer, N-benzylpiperazino derivatives
of 3-nitro-4-hydroxycoumarin with H1 antihistamine and mast cell stabilizing
properties, J. Med. Chem., 27, 1452 (1984).
(9) T. Nasr, S. Bondock, M. Youns, Anticancer activity of new coumarin substituted
hydrazide-hydrazone derivatives, Eur. J. Med. Chem., 76, 539 (2014).
(10) A.A. Al-Amiery, A.A.H. Kadhum, A.B. Mohamad, Antifungal activities of new
coumarins, Molecules, 17, 5713 (2012).
(11) B.S. Jayashree, S. Nigam, A. Pai, P.V.R. Chowdary, Overview on the recently
developed coumarinyl heterocycles as useful therapeutic agents, Arabian J.
Chem., 7, 885 (2014).
(12) A. Manvar, A. Malde, J. Verma, V. Virsodia, A. Mishra, K. Upadhyay, H. Achrya,
E. Coutinho, A. Shah, Synthesis anti-tubercular active and 3D QSAR study
of coumarin-4-acetic acid benzylidene hydrazides, Eur. J. Med. Chem., 43, 2395
(2008).
(13) R.K. Arora, N. Kaur, Y. Bansal, G. Bansal, Novel coumarin-benzimidazole derivatives
as antioxidant and safer anti-inflammatory agent, Acta Pharm. Sinica B, 4,
(2014).
(14) J. Sahoo, S.K. Mekap, P.S. Kumar, Synthesis, spectral characterization of some
new 3-heteroaryl azo 4-hydroxy coumarin derivatives and their antimicrobial
evaluation, J. Taibah Univ. Sci., 9, 187 (2015).
(15) D. Yu. M. Suzuki, L. Xie, S. L. Morris-Natschke, K. H. Lee, Recent progress in
the development of coumarin derivatives as potent anti-HIV agent, Med. Res.
Rev., 23, 322 (2003).
(16) U.C. Mashelkar, S. S. Tungare, S. Bhagat, Studies on synthesis of various N-substituted
derivatives with different heterocycles and their herbicidal activity, Ind.
J. Chem., 50B, 315 (2011).
(17) P.A. Vadola, D. Sames, Catalytic coupling of arene C-H bonds and alkynes for
the synthesis of coumarins: substrate scope and application to the development
of neuroimaging agents, J. Org. Chem., 77, 7804 (2012).
(18) R. Rajagopal, V.U. Shenoy, S. Padmanabhan, S. Sequeria, S. Seshadri, Synthesis
of fluorescent 2,3-fused coumarin derivatives, Dyes Pigments, 13, 167 (1990).
(19) R. Sanchez-de-Armas, M.A.S. Miguel, J. Oviedo, J.F. Sanz, Coumarin derivatives
for dye sensitized solar cells: a TD-DFT study, Phys. Chem. Chem. Phys., 14,
, (2012).
(20) J.A. Riddick, W.B. Bunger, T. Sakano, “Organic solvents-physical properties
and methods of purification, techniques of Chemistry”, II, A Wiley-Interscience
Publication, John Wiley, New York, 1986.
(21) J. Parekh, P. Inamdar, R. Nair, S. Baluja, S. Chanda, Synthesis and antibacterial
activity of some Schiff bases derived from 4-aminobenzoic acid, J. Serb. Chem.
Soc., 70, 1155 (2005).
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