Publicado

2020-11-03

Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases

Compuestos aislados de Bixa orellana: avances basados en la evidencia para tratar enfermedades infecciosas

DOI:

https://doi.org/10.15446/rcciquifa.v49n3.91247

Palabras clave:

Natural products, antimicrobial activity, human pathogens, phytochemical compounds (en)
Productos naturales, actividad antimicrobiana, patógenos humanos, compuestos fitoquímicos (es)

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Autores/as

  • Roberval Nascimento Moraes Neto Laboratório de Imunologia e Microbiologia das Infecções Respiratórias, Programa de Mestrado em Biologia Microbiana, Universidade CEUMA, Maranhão
  • Gabrielle Guedes Coutinho Laboratório de Imunologia e Microbiologia das Infecções Respiratórias, Programa de Mestrado em Biologia Microbiana, Universidade CEUMA, Maranhão
  • Aline de Oliveira Rezende Laboratório de Imunologia e Microbiologia das Infecções Respiratórias, Programa de Mestrado em Biologia Microbiana, Universidade CEUMA, Maranhão
  • Daniel de Brito Pontes Laboratório de Imunologia e Microbiologia das Infecções Respiratórias, Programa de Mestrado em Biologia Microbiana, Universidade CEUMA, Maranhão
  • Rayana Larissa Pinheiro Soares Ferreira Laboratório de Imunologia e Microbiologia das Infecções Respiratórias, Programa de Mestrado em Biologia Microbiana, Universidade CEUMA, Maranhã
  • Danilo de Araújo Morais Laboratório de Imunologia e Microbiologia das Infecções Respiratórias, Programa de Mestrado em Biologia Microbiana, Universidade CEUMA, Maranhão
  • Rafaela Pontes Albuquerque Laboratório de Imunologia e Microbiologia das Infecções Respiratórias, Programa de Mestrado em Biologia Microbiana, Universidade CEUMA, Maranhão
  • Lídio Gonçalves Lima-Neto Laboratório de Imunologia e Microbiologia das Infecções Respiratórias, Programa de Mestrado em Biologia Microbiana, Universidade CEUMA, Maranhão
  • Luís Cláudio Nascimento da Silva Laboratório de Imunologia e Microbiologia das Infecções Respiratórias, Programa de Mestrado em Biologia Microbiana, Universidade CEUMA, Maranhão
  • Cláudia Quintino da Rocha Centro de Ciência e Tecnologia, Departamento de Química, Universidade Federal do Maranhão
  • Letícia Machado Gonçalves Programa de Pós-Graduação em Odontologia, Universidade CEUMA, Maranhão
  • Luís Ângelo Macedo Santiago Programa de Pósgraduação em Biodiversidade e Biotecnologia da Rede Bionorte, Maranhão
  • Renata Mondego-Oliveira Rede Nordeste de Biotecnologia, Programa, Universidade Federal do Maranhão, Maranhão
  • Rafael Cardoso Carvalho Laboratório de Imunologia e Microbiologia das Infecções Respiratórias, Programa de Mestrado em Biologia Microbiana, Universidade CEUMA, Maranhão
  • Eduardo Martins de Sousa Laboratório de Imunologia e Microbiologia das Infecções Respiratórias, Programa de Mestrado em Biologia Microbiana, Universidade CEUMA, Maranhão

Bixa orellana L. is a native plant from Brazil, but it is also present in other tropical countries such as Peru, Colombia, Ecuador, Mexico, Indonesia, India and East Africa. It is popularly known as Urucum in Brazil. This review shows the potential of bioactive compounds derived from B. orellana to treat infectious diseases due their antimicrobial and antioxidant properties. This plant is also related as an anti-inflammatory agent for treatment of pulmonary diseases, or even as eye drops for redness. Its leaves are used for treatment of snakebite, diarrhea, gonorrhea, hepatitis, gastritis, diuretic, antipyretic, and for skin disease. This popular knowledge has encouraged the identification of bioactive compounds in this plant. Compounds as β-cryptoxanthin, geranylgeraniol, lutein, procyanidin B2, procyanidin B3, ellagitannin isomer and ellagic acid deoxyhexose have been described. These compounds inhibited pathogenic microorganisms such as bacteria, fungi, protozoan and viruses. In addition, some compounds with anti-inflammatory and antioxidant activities were also described. In this sense, B. orellana is a promising source of compounds that could be applied in antimicrobial therapy. This review work may help in the understanding and incentive of new research for antimicrobial discoveries using different B. orellana compounds.

Bixa orellana L. es una planta nativa de Brasil, pero también está presente en otros países tropicales como Perú, Colombia, Ecuador, México, Indonesia, India y África Oriental. Es conocida popularmente como Urucum en Brasil. Esta revisión expone el potencial de los compuestos bioactivos derivados de B. orellana para tratar enfermedades debido a sus propiedades antimicrobianas y antioxidantes. Esta planta también está relacionada como un agente antiinflamatorio para el tratamiento de enfermedades pulmonares e incluso como gotas para los ojos para el enrojecimiento. Sus hojas se utilizan para el tratamiento de la mordedura de serpiente, diarrea, gonorrea, hepatitis, gastritis, diuréticos, antipiréticos y para enfermedades de la piel. Ese conocimiento popular ha fomentado la identificación de compuestos bioactivos en esa planta. Los compuestos β-criptoxantina, geranilgeraniol, luteína, procianidina B2, procianidina B3, isómero elagitanino y ácido elágico desoxihexosa inhibieron microorganismos patógenos como bacterias, hongos, protozoos y virus. En ese sentido, B. orellana es una fuente prometedora de compuestos que podrían aplicarse en la terapia antimicrobiana. Este trabajo de revisión puede ayudar a comprender e incentivar nuevas investigaciones para los descubrimientos de antimicrobianos que utilizan diferentes compuestos de B. orellana.

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Cómo citar

APA

Moraes Neto, R. N., Guedes Coutinho, G. ., de Oliveira Rezende, A. ., de Brito Pontes, D. ., Pinheiro Soares Ferreira, R. L., de Araújo Morais, D., Pontes Albuquerque, R. ., Lima-Neto, L. G. ., Nascimento da Silva, L. C. ., Quintino da Rocha, C. ., Machado Gonçalves, L. ., Macedo Santiago, L. Ângelo ., Mondego-Oliveira , R. ., Cardoso Carvalho, R. . y Martins de Sousa, E. . (2020). Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases. Revista Colombiana de Ciencias Químico-Farmacéuticas, 49(3). https://doi.org/10.15446/rcciquifa.v49n3.91247

ACM

[1]
Moraes Neto, R.N., Guedes Coutinho, G. , de Oliveira Rezende, A. , de Brito Pontes, D. , Pinheiro Soares Ferreira, R.L., de Araújo Morais, D., Pontes Albuquerque, R. , Lima-Neto, L.G. , Nascimento da Silva, L.C. , Quintino da Rocha, C. , Machado Gonçalves, L. , Macedo Santiago, L. Ângelo ., Mondego-Oliveira , R. , Cardoso Carvalho, R. y Martins de Sousa, E. 2020. Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases. Revista Colombiana de Ciencias Químico-Farmacéuticas. 49, 3 (nov. 2020). DOI:https://doi.org/10.15446/rcciquifa.v49n3.91247.

ACS

(1)
Moraes Neto, R. N.; Guedes Coutinho, G. .; de Oliveira Rezende, A. .; de Brito Pontes, D. .; Pinheiro Soares Ferreira, R. L.; de Araújo Morais, D.; Pontes Albuquerque, R. .; Lima-Neto, L. G. .; Nascimento da Silva, L. C. .; Quintino da Rocha, C. .; Machado Gonçalves, L. .; Macedo Santiago, L. Ângelo .; Mondego-Oliveira , R. .; Cardoso Carvalho, R. .; Martins de Sousa, E. . Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases. Rev. Colomb. Cienc. Quím. Farm. 2020, 49.

ABNT

MORAES NETO, R. N.; GUEDES COUTINHO, G. .; DE OLIVEIRA REZENDE, A. .; DE BRITO PONTES, D. .; PINHEIRO SOARES FERREIRA, R. L.; DE ARAÚJO MORAIS, D.; PONTES ALBUQUERQUE, R. .; LIMA-NETO, L. G. .; NASCIMENTO DA SILVA, L. C. .; QUINTINO DA ROCHA, C. .; MACHADO GONÇALVES, L. .; MACEDO SANTIAGO, L. Ângelo .; MONDEGO-OLIVEIRA , R. .; CARDOSO CARVALHO, R. .; MARTINS DE SOUSA, E. . Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 49, n. 3, 2020. DOI: 10.15446/rcciquifa.v49n3.91247. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/91247. Acesso em: 20 abr. 2025.

Chicago

Moraes Neto, Roberval Nascimento, Gabrielle Guedes Coutinho, Aline de Oliveira Rezende, Daniel de Brito Pontes, Rayana Larissa Pinheiro Soares Ferreira, Danilo de Araújo Morais, Rafaela Pontes Albuquerque, Lídio Gonçalves Lima-Neto, Luís Cláudio Nascimento da Silva, Cláudia Quintino da Rocha, Letícia Machado Gonçalves, Luís Ângelo Macedo Santiago, Renata Mondego-Oliveira, Rafael Cardoso Carvalho, y Eduardo Martins de Sousa. 2020. «Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases». Revista Colombiana De Ciencias Químico-Farmacéuticas 49 (3). https://doi.org/10.15446/rcciquifa.v49n3.91247.

Harvard

Moraes Neto, R. N., Guedes Coutinho, G. ., de Oliveira Rezende, A. ., de Brito Pontes, D. ., Pinheiro Soares Ferreira, R. L., de Araújo Morais, D., Pontes Albuquerque, R. ., Lima-Neto, L. G. ., Nascimento da Silva, L. C. ., Quintino da Rocha, C. ., Machado Gonçalves, L. ., Macedo Santiago, L. Ângelo ., Mondego-Oliveira , R. ., Cardoso Carvalho, R. . y Martins de Sousa, E. . (2020) «Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases», Revista Colombiana de Ciencias Químico-Farmacéuticas, 49(3). doi: 10.15446/rcciquifa.v49n3.91247.

IEEE

[1]
R. N. Moraes Neto, «Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases», Rev. Colomb. Cienc. Quím. Farm., vol. 49, n.º 3, nov. 2020.

MLA

Moraes Neto, R. N., G. . Guedes Coutinho, A. . de Oliveira Rezende, D. . de Brito Pontes, R. L. Pinheiro Soares Ferreira, D. de Araújo Morais, R. . Pontes Albuquerque, L. G. . Lima-Neto, L. C. . Nascimento da Silva, C. . Quintino da Rocha, L. . Machado Gonçalves, L. Ângelo . Macedo Santiago, R. . Mondego-Oliveira, R. . Cardoso Carvalho, y E. . Martins de Sousa. «Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases». Revista Colombiana de Ciencias Químico-Farmacéuticas, vol. 49, n.º 3, noviembre de 2020, doi:10.15446/rcciquifa.v49n3.91247.

Turabian

Moraes Neto, Roberval Nascimento, Gabrielle Guedes Coutinho, Aline de Oliveira Rezende, Daniel de Brito Pontes, Rayana Larissa Pinheiro Soares Ferreira, Danilo de Araújo Morais, Rafaela Pontes Albuquerque, Lídio Gonçalves Lima-Neto, Luís Cláudio Nascimento da Silva, Cláudia Quintino da Rocha, Letícia Machado Gonçalves, Luís Ângelo Macedo Santiago, Renata Mondego-Oliveira, Rafael Cardoso Carvalho, y Eduardo Martins de Sousa. «Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases». Revista Colombiana de Ciencias Químico-Farmacéuticas 49, no. 3 (noviembre 3, 2020). Accedido abril 20, 2025. https://revistas.unal.edu.co/index.php/rccquifa/article/view/91247.

Vancouver

1.
Moraes Neto RN, Guedes Coutinho G, de Oliveira Rezende A, de Brito Pontes D, Pinheiro Soares Ferreira RL, de Araújo Morais D, Pontes Albuquerque R, Lima-Neto LG, Nascimento da Silva LC, Quintino da Rocha C, Machado Gonçalves L, Macedo Santiago L Ângelo, Mondego-Oliveira R, Cardoso Carvalho R, Martins de Sousa E. Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 3 de noviembre de 2020 [citado 20 de abril de 2025];49(3). Disponible en: https://revistas.unal.edu.co/index.php/rccquifa/article/view/91247

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1. Wenyi Zhou, Lei Zhao, Kai Wang, Catherine M. G. C. Renard, Carine Le Bourvellec, Zhuoyan Hu, Xuwei Liu. (2024). Plant leaf proanthocyanidins: from agricultural production by-products to potential bioactive molecules. Critical Reviews in Food Science and Nutrition, 64(32), p.11757. https://doi.org/10.1080/10408398.2023.2244079.

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