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Atividade fotoprotetora e antioxidante de compostos fenólicos: uma revisão sistemática de testes in vitro
Photoprotective and antioxidant activity of phenolic compounds: a systematic review of in vitro tests
Actividad fotoprotectora y antioxidante de compuestos fenólicos: una revisión sistemática de ensayos in vitro
DOI:
https://doi.org/10.15446/rcciquifa.v51n2.97604Palabras clave:
Protetores solares, compostos fenólicos, técnicas in vitro, ensaio biológico (pt)Filtros solares, compuestos fenólicos, técnicas in vitro, ensayo biológico (es)
Sunscreens, phenolic compounds, in vitro techniques, biological assay (en)
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Introdução: os compostos fenólicos, devido a sua estrutura química, possuem a capacidade de absorver a energia ultravioleta e reduzir a formação de radicais livres. Objetivo: avaliar a atividade fotoprotetora e antioxidante de compostos fenólicos a partir da observação de resultados in vitro e verificar a importância do uso de modelos biológicos nessa perspectiva. Metodologia: foi realizada uma pesquisa de artigos publicados, na base de dados Pubmed, entre 2010 e 2020, que atendessem aos objetivos deste trabalho, 44 artigos foram selecionados. Resultados: os métodos instrumentais utilizados para avaliação da atividade fotoprotetora apresentaram boa correlação in vivo e mostram-se rápidos e eficazes na determinação do fator de proteção solar. Além desses, têm-se aplicado métodos biológicos para a avaliação de aspectos que não são mensurados por métodos físico-químicos, relacionado aos danos ao DNA, decorrentes da exposição solar. Para a avaliação da atividade antioxi-dante, o método do radical DPPH foi empregado em 92,6 % dos estudos analisados e foi observado que os antioxidantes podem incrementar a proteção solar e, ainda, auxiliar na estabilidade de filtros solares sintéticos. Conclusão: os compostos fenó-licos, especialmente aqueles com propriedades antioxidantes, podem ser utilizados como agentes fotoprotetores em formulações tópicas para reduzir os danos à pele induzidos pela radiação UV.
Introduction: Phenolic compounds, due to their chemical structure, can absorb ultraviolet energ y and reduce the formation of free radicals. Aim: To evaluate the photoprotective and antioxidant activity of phenolic compounds from the observa-tion of in vitro results and to verify the importance of the use of biological models in this perspective. Methodology: A search for articles published in the Pubmed database was carried out between 2010 and 2020, which met the objectives of this work, 44 articles were selected. Results: According to the literature, the instru-mental methods used to assess independent photoprotective activity, good correla-tion in vivo, and demonstrating rapid and effective determination of the sun protec-tion factor. In addition to these, biological methods have been provided for the evaluation of aspects not measured by physical-chemical methods, related to DNA damage, resulting from sun exposure. For the evaluation of antioxidant activity, the DPPH radical method was registered in 92.6 % of published studies and it was observed that antioxidants can increase sun protection and also help in the stability of synthetic sunscreens. Conclusion: Phenolic compounds, especially with antioxi-dant properties, can be used as photoprotective agents in topical formulations to reduce skin damage induced by UV radiation.
Introducción: los compuestos fenólicos, por su estructura química, tienen la capa-cidad de absorber la energía ultravioleta y reducir la formación de radicales libres. Objetivo: evaluar la actividad fotoprotectora y antioxidante de compuestos fenó-licos a partir de la observación de resultados in vitro y comprobar la importancia del uso de modelos biológicos en esta perspectiva. Metodología: se realizó una búsqueda de artículos publicados en la base de datos Pubmed entre 2010 y 2020, que cumplieron con los objetivos de este trabajo, se seleccionaron 44 artículos. Resul-tados: los métodos instrumentales utilizados para evaluar la actividad fotoprotec-tora mostraron una buena correlación in vivo y demostraron ser rápidos y eficientes en la determinación del factor de protección solar. Además de estos, se aplicaron métodos biológicos para evaluar aspectos no medidos por métodos físico-químicos, relacionados con el daño en el ADN por exposición solar. Para la evaluación de la actividad antioxidante se utilizó el método radical DPPH en el 92,6% de los estudios analizados y se observó que los antioxidantes pueden aumentar la protección solar y también ayudar en la estabilidad de los protectores solares sintéticos. Conclusión:los compuestos fenólicos, especialmente aquellos con propiedades antioxidantes, pueden utilizarse como agentes fotoprotectores en formulaciones tópicas para reducir el daño cutáneo inducido por la radiación UV.
Referencias
M. Dantas-Mota, A.N. da Boa-Morte, L.C.R. Cerqueira e Silva, F.A. Chinalia,Sunscreen protection factor enhancement through supplementation with Rambutan (Nephelium lappaceumL) ethanolic extract, J. Photochem. Photo-biol. B, Biol., 205, 111837 (2020). DOI: https://doi.org/10.1016/j.jphotobiol.2020.111837
D.H. McDaniel, J.M. Waugh, L.I. Jiang, T.J. Stephens, A. Yaroshinsky, C. Mazur, M. Wortzman, D.B. Nelson, Evaluation of the antioxidant capacity and protec-tive effects of a comprehensive topical antioxidant containing water-soluble, enzymatic, and lipid-soluble antioxidants, J. Clin. Aesthet. Dermatol., 12(4), 46-53 (2019).
E. Gregoris, G.P. Pereira-Lima, S. Fabris, M. Bertelle, M. Sicari, R. Stevanato, Antioxidant properties of Brazilian tropical fruits by correlation between diffe-rent assays, Biomed. Res. Int., 2013, 132759 (2013). DOI: https://doi.org/10.1155/2013/132759
J.P.S. Silveira, L.N. Seito, S. Eberlin, G.C. Dieamant, C. Nogueira, M.C.V. Pereda, et al., Photoprotective and antioxidant effects of Rhubarb: Inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1α and α-MSH produc-tion in human melanocytes, BMC Complement. Altern. Med., 13, 49 (2013). DOI: https://doi.org/10.1186/1472-6882-13-49
A.R. Nunes, A.L.M. Rodrigues, D.B. de Queiróz, I.G.P. Vieira, J.F.C. Neto, J.T.C. Junior, et al., Photoprotective potential of medicinal plants from Cerrado biome (Brazil) in relation to phenolic content and antioxidant activity, J. Photo-chem. Photobiol. B, Biol., 189, 119-123 (2018). DOI: https://doi.org/10.1016/j.jphotobiol.2018.10.013
S.C.C.Costa, C.B. Detoni, C.R.C. Branco, M.B. Botura, A. Branco, In vitrophotoprotective effects of Marcetia taxifolia ethanolic extract and its potential for sunscreen formulations, Braz. J. Pharmacogn., 25(4), 413-418 (2015). DOI: https://doi.org/10.1016/j.bjp.2015.07.013
A. Rajnochová-Svobodová, E. Gabrielová, L. Michaelides, P. Kosina, A. Ryšavá, J. Ulrichová, et al., UVA-photoprotective potential of silymarin and silybin, Arch. Dermatol. Res., 310(5), 413-424 (2018). DOI: https://doi.org/10.1007/s00403-018-1828-6
K.B. Wróblewska, A.R. Baby, M.T. Grombone-Guaratini, P.R.H. Moreno, In vitro antioxidant and photoprotective activity of five native Brazilian bamboo species, Ind. Crops Prod., 130, 208-215 (2019). DOI: https://doi.org/10.1016/j.indcrop.2018.12.081
M.K. Bulla, L. Hernandes, M.L. Baesso, A.C. Nogueira, A.C. Bento, B.B. Borto-luzzi, et al., Evaluation of photoprotective potential and percutaneous penetration by photoacoustic spectroscopy of the Schinus terebinthifolius Raddi extract, Photochem. Photobiol., 91(3), 558-566 (2015). DOI: https://doi.org/10.1111/php.12419
R. Stevanato, M. Bertelle, S. Fabris, Photoprotective characteristics of natural antioxidant polyphenols, Regulatory Toxicolog y and Pharmacolog y, 69, 71-77 (2014). DOI: https://doi.org/10.1016/j.yrtph.2014.02.014
R.V. Silva, S.C.C. Costa, C.R.C. Branco, A. Branco, In vitro photoprotective activity of the Spondias purpurea L. peel crude extract and its incorporation in a pharmaceutical formulation, Ind. Crops Prod., 83, 509-514 (2016). DOI: https://doi.org/10.1016/j.indcrop.2015.12.077
J.F.F.Orlanda, V.V. Vale, Análise fitoquímica e atividade fotoprotetora de extrato etanólico de Euphorbia tirucalli Linneau (Euphorbiaceae), Rev. Bras. Plantas Med., 17, 730-736 (2015). DOI: https://doi.org/10.1590/1983-084X/14_012
A. Hubner, F. Sobreira, A.V. Neto, C.A.S. de Oliveira-Pinto, M.F. Dario, I.E.C. Díaz, et al., The synergistic behavior of antioxidant phenolic compounds obtai-ned fromwinemaking waste’s valorization, increased the efficacy of a sunscreen system, Antioxidants (Basel), 8(11), 530 (2019). DOI: https://doi.org/10.3390/antiox8110530
A.S. Fernandes, J.L. Mazzei, H. Evangelista, M.R.C. Marques, E.R.A. Ferraz, I. Felzenszwalb, Protection against UV-induced oxidative stress and DNA damage by Amazon moss extracts, J. Photochem. Photobiol. B, Biol., 183, 331-341 (2018). DOI: https://doi.org/10.1016/j.jphotobiol.2018.04.038
Brasil, Ministério da Saúde, Agência Nacional de Vigilância Sanitária, Resolução da Diretoria Colegiada-RDC n° 30 de 01 de junho de 2012, Diário da República Federativa do Brasil, 1-8, 2012.
US Food and Drug Administration,Sunscreen drug products for over-the-coun-ter human use: proposed rule, [Internet]. Vol. 84, Federal Register, 2019,URL: https://www.federalregister.gov/documents/2019/02/26/2019-03019/suns-creen-drug- products-for-over-the-counter-human-use. Acesso em outubro, 2020.
A.D. Cvetkovska, S. Manfredini, P. Ziosi, S. Molesini, V. Dissette, I. Magri, et al., Factors affecting SPF in vitro measurement and correlation with in vivo results, Int. J. Cosmet. Sci., 39(3), 310-319 (2017). DOI: https://doi.org/10.1111/ics.12377
M.C.P.P. Mansur, S.G. Leitão-Reis, C. Cerqueira-Coutinho, A.B. Vermelho, R.S. Silva, O.A.F. Presgrave, et al., In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts, Rev. Bras. Farmacogn., 26(2), 251-258 (2016). DOI: https://doi.org/10.1016/j.bjp.2015.11.006
M.A. Khan, Sun protection factor determination studies of some sunscreen for-mulations used in cosmetics for their selection, J. Drug Deliv. Therap., 8(5-s), 149-151 (2018). DOI: https://doi.org/10.22270/jddt.v8i5-s.1924
H.C. Polonini, L.L. Lima, K.M. Gonçalves, A.M.R. Do Carmo, A.D. Da Silva, N.R.B. Raposo, Photoprotective activity of resveratrol analogues, Bioorg.Med. Chem., 21(4), 964-968 (2013). DOI: https://doi.org/10.1016/j.bmc.2012.11.052
I.F. Almeida, A.S. Pinto, C. Monteiro, H. Monteiro, L. Belo, J. Fernandes, et al., Protective effect of C. sativa leaf extract against UV mediated-DNA damage in a human keratinocyte cell line, J. Photochem. Photobiol. B, Biol., 144, 28-34 (2015). DOI: https://doi.org/10.1016/j.jphotobiol.2015.01.010
T. Baccarin, M. Mitjans, D. Ramos, E. Lemos-Senna, M.P. Vinardell, Photopro-tection by Punica granatum seed oil nanoemulsion entrapping polyphenol-rich ethyl acetate fraction against UVB-induced DNA damage in human keratino-cyte (HaCaT) cell line, J. Photochem. Photobiol. B, Biol., 153, 127-136 (2015). DOI: https://doi.org/10.1016/j.jphotobiol.2015.09.005
L.T.N. Ngoc,V.V. Tran, J.-Y. Moon,M. Chae,D. Park,Y.-C. Lee, Recent trends of sunscreen cosmetic: An update review, Cosmetics, 6(4), 64 (2019). DOI: https://doi.org/10.3390/cosmetics6040064
J.d.S. Mansur, M.N.R. Breder, M.C.d’A. Mansur, R.D. Azulay, Determinaçäo do fator de proteçäo solar por espectrofotometria, An. Bras. Dermatol., 61(3), 121-124 (1986).
M.D. Mota, R.Y.S. Costa, A.a.a. Silva-Guedes, L.C.R. Cerqueira e Silva, F.A. Chinalia, Guava-fruit extract can improve the UV-protection efficiency of synthetic filters in sun cream formulations, J. Photochem. Photobiol. B, Biol., 201, 111639 (2019). DOI: https://doi.org/10.1016/j.jphotobiol.2019.111639
B.L. Diffey, J. Robson, A new substrate to measure sunscreen protection fac-tors throughout the ultraviolet spectrum, J. Soc. Cosmet. Chem., 40(3), 127-133 (1989).
M. Hupel, N. Poupart, E.A. Gall, Development of a new in vitro method to eva-luate the photoprotective sunscreen activity of plant extracts against high UV-B radiation, Ta l a n t a, 86(1), 362-371 (2011). DOI: https://doi.org/10.1016/j.talanta.2011.09.029
S.I. Yang, S. Liu, G.J. Brooks, Y. Lanctot, J.V. Gruber, Reliable and simple spec-trophotometric determination of sun protection factor: A case study using orga-nic UV filter-based sunscreen products, J. Cosmet. Dermatol., 17(3), 518-522 (2018). DOI: https://doi.org/10.1111/jocd.12390
A.d.S.T. Cardoso, S.S. Santos, C.V. Silva, E.C.L. Cazedey, Green analytical methods for isosorbide dinitrate determination by UV spectrophotometry and stability indicating HPLC-PDA, Braz. J. Health Rev., 3(3), 5153-5161 (2020). DOI: https://doi.org/10.34119/bjhrv3n3-093
P. Buso, M. Radice, A. Baldisserotto, S. Manfredini, S. Vertuani, Guidelines for the development of herbal-based sunscreen, In: P.F. Builders (editor), Herbal Medicine [Internet], IntechOpen, London, 2017, [cited 2020, April 10]. URL: https://www.intechopen.com/chapters/58422 doi: 10.5772/intechopen.72712 DOI: https://doi.org/10.5772/intechopen.72712
A.P. Schuch, M.C.S. Moraes, T. Yagura, C.F.M. Menck, Highly sensitive biologi-cal assay for determining the photoprotective efficacy of sunscreen, Environ. Sci. Technol., 48(19), 11584-11590 (2014). DOI: https://doi.org/10.1021/es503721a
A.C.P. Da Silva, J.P. Paiva, R.R. Diniz, V.M. Dos Anjos, A.B.S.M. Silva, A.V. Pinto, et al., Photoprotection assessment of olive (Olea europaea L.) leaves extract standardized to oleuropein: In vitro and in silico approach for improved sunscreens, J. Photochem. Photobiol. B, Biol.,193, 162-171 (2019). DOI: https://doi.org/10.1016/j.jphotobiol.2019.03.003
S.A. Figueiredo, F.M.P. Vilela, C.A. Da Silva,T.M. Cunha, M.H. Dos Santos, M.J.V. Fonseca,In vitro and in vivo photoprotective/photochemopreventive potential of Garcinia brasiliensis epicarp extract, J. Photochem. Photobiol. B, Biol., 131, 65-73 (2014). DOI: https://doi.org/10.1016/j.jphotobiol.2014.01.004
A. García-Forero, D.A. Villamizar-Mantilla, L.A. Núñez, R.E. Ocazionez, E.E. Stashenko, J.L. Fuentes, Photoprotective and antigenotoxic effects of the fla-vonoids apigenin, naringenin and pinocembrin, Photochem. Photobiol., 95(4), 1010-1018 (2019). DOI: https://doi.org/10.1111/php.13085
S. Hu, F. Chen, M. Wang, Photoprotective effects of oxyresveratrol and kuwa-non O on DNA damage induced by UVA in human epidermal keratinocytes, Chem. Res. Toxicol., 28(3), 541-548 (2015). DOI: https://doi.org/10.1021/tx500497u
V. Kostyuk, A. Potapovich, A.R. Albuhaydar, W. Mayer, C. de Luca, L. Korkina, Natural substances for prevention of skin photoaging : Screening systems in the development of sunscreen and rejuvenation cosmetics, Rejuvenation Res., 21(2), 91-101 (2018). DOI: https://doi.org/10.1089/rej.2017.1931
S. Skrovankova, D. Sumczynski, J. Mlcek, T. Jurikova, J. Sochor, Bioactive com-pounds and antioxidant activity in different types of berries, Int. J. Mol. Sci., 16(10), 24673-24706 (2015). DOI: https://doi.org/10.3390/ijms161024673
M. Gasparrini, T.Y. Forbes-Hernandez, S. Afrin, P. Reboredo-Rodriguez, D. Cianciosi, B. Mezzetti, et al., Strawberry-based cosmetic formulations protect human dermal fibroblasts against UVA-induced damage, Nutrients, 9(6), 605 (2017). DOI: https://doi.org/10.3390/nu9060605
A.S. Fernandes, J.L. Mazzei, C.G. Oliveira, H. Evangelista, M.R.C. Marques, E.R.A. Ferraz, et al., Protection against UV-induced toxicity and lack of mutage-nicity of Antarctic Sanionia uncinata, Toxicolog y, 376, 126-136 (2017). DOI: https://doi.org/10.1016/j.tox.2016.05.021
M. Lefahal, N. Zaabat, R. Ayad, E. Makhloufi, L. Djarri, M. Benahmed,et al.,In vitro assessment of total phenolic and flavonoid contents, antioxidant and photo-protective activities of crude methanolic extract of aerial parts of Capnophyllum peregrinum (L.) Lange (Apiaceae) growing in Algeria, Medicines (Basel), 5(2), 26 (2018). DOI: https://doi.org/10.3390/medicines5020026
A. Pérez-Sánchez, E. Barrajón-Catalán, M. Herranz-López, J. Castillo, V. Micol, Lemon balm extract (Melissa officinalis, L.) promotes melanogenesis and pre-vents UVB-induced oxidative stress and DNA damage in a skin cell model, J. Dermatol. Sci., 84(2), 169-177 (2016). DOI: https://doi.org/10.1016/j.jdermsci.2016.08.004
A. Smerilli, S. Balzano, M. Maselli, M. Blasio, I. Orefice, C. Galasso, et al., Antio-xidant and photoprotection networking in the coastal diatom Skeletonema mari-noi, Antioxidants, 8(6), 154 (2019). DOI: https://doi.org/10.3390/antiox8060154
D.d.S. Baldivia, D.F. Leite, D.T.H. de Castro, J.F. Campos, U.P. Dos Santos, E.J. Paredes-Gamero, et al., Evaluation of in vitro antioxidant and anticancer proper-ties of the aqueous extract from the stem bark of Stryphnodendron adstringens, Int. J. Mol. Sci., 19(8), 2432 (2018). DOI: https://doi.org/10.3390/ijms19082432
T. Baccarin, E. Lemos-Senna, Potential application of nanoemulsions for skin delivery of pomegranate peel polyphenols, AAPS PharmSciTech, 18(8), 3307-3314 (2017). DOI: https://doi.org/10.1208/s12249-017-0818-x
C.M. Batista, A.V.F. Alves, L.A. Queiroz, B.S. Lima, R.N.P. Filho, A.A.S. Araújo, et al.,The photoprotective and anti-inflammatory activity of red propolis extract in rats, J. Photochem.Photobiol. B, Biol.,180, 198-207 (2018). DOI: https://doi.org/10.1016/j.jphotobiol.2018.01.028
R. Camacho-Sandoval, E.N. Sosa-Grande, E. González-González, A. Tenorio-Calvo, C.A. López-Morales, M. Velasco-Velázquez, et al., Development and validation of a bioassay to evaluate binding of adalimumab to cell membrane-anchored TNFα using flow cytometry detection, J. Pharm. Biomed. Anal., 155, 235-240 (2018). DOI: https://doi.org/10.1016/j.jpba.2018.03.057
L.Chen, J.Y. Hu, S . Q .Wa n g, The role of antioxidants in photoprotection: A criti-cal review, J. Am. Acad. Dermatol., 67(5), 1013-1024 (2012). DOI: https://doi.org/10.1016/j.jaad.2012.02.009
A.R.A. Da Silva, S.M. de Morais, M.M. Mendes-Marques, D.F. de Oliveira, C.C. Barros, R.R. de Almeida, et al., Chemical composition, antioxidant and antibac-terial activities of two Spondias species from Northeastern Brazil, Pharm. Biol., 50(6), 740-746 (2012). DOI: https://doi.org/10.3109/13880209.2011.627347
F.J. Martins, C.A. Caneschi, J.L.F. Vieira, W. Barbosa, N.R.B. Raposo, Antioxi-dant activity and potential photoprotective from Amazon native flora extracts, J. Photochem.Photobiol. B, Biol., 161, 34-39 (2016). DOI: https://doi.org/10.1016/j.jphotobiol.2016.05.012
R. Guimarães de Sousa, A.D. da Silva-Lima,E. Neves de Lima, Incremento da atividade fotoprotetora e antioxidante de cosméticos contendo extratos vegetais da caatinga, Braz. J. Nat. Sci., 3(1), 225-230 (2020). DOI: https://doi.org/10.31415/bjns.v3i1.83
A. Lohani, A.K. Mishra, A. Verma, Cosmeceutical potential of geranium and calendula essential oil: Determination of antioxidant activity and in vitro sun protection factor, J. Cosmet. Dermatol., 18(2), 550-557 (2019). DOI: https://doi.org/10.1111/jocd.12789
A.K. Mishra, A. Mishra, P. Chattopadhyay, Herbal cosmeceuticals for photo-protection from ultraviolet B radiation: A review, Trop. J. Pharm. Res., 10(3), 351-360 (2011). DOI: https://doi.org/10.4314/tjpr.v10i3.7
R. Guimarâes-Ramos, J. Feitosa-Moura, V. Da Silva-Lima, R. Da Conceição-Santos, A. Macário de Oliveira, L.A.L. Soares, Estudo comparativo da compo-sição fitoquímica, citotoxidade e potencias antioxidante e fotoprotetor da casca e folha de Erythrina velutina, Braz. J. Develop., 6(6), 33140-33158 (2020). DOI: https://doi.org/10.34117/bjdv6n6-026
M.A. Olszewska,In vitro antioxidant activity and total phenolic content of the inflorescences, leaves and fruits of Sorbus torminalis (L.) Crantz, Acta Pol. Pharm. Drug Res., 68(6), 945-953 (2011).
V. Dal-Prá, F.C. Lunelli, R.G. Vendruscolo, R. Martins, R. Wagner, A.P. Lazza-retti, et al., Ultrasound-assisted extraction of bioactive compounds from palm pressed fiber with high antioxidant and photoprotective activities, Ultrason. Sonochem., 36, 362-366 (2017). DOI: https://doi.org/10.1016/j.ultsonch.2016.12.021
S.R.G. de Lima-Saraiva, F.G.d.S. Oliveira, R.G. de Oliveira Junior, C. de Sousa-Araújo, A.P. de Oliveira,A.G.M. Pacheco,et al.,Chemical analysis and evaluation of antioxidant, antimicrobial, and photoprotective activities of Schinopsis brasi-liensis Engl. (Anacardiaceae), Sci. World J., 2017, ID 1713921 (2017). DOI: https://doi.org/10.1155/2017/1713921
A. Baldisserotto, P. Buso, M. Radice, V. Dissette, I. Lampronti, R. Gambari, et al., Moringa oleifera leaf extracts as multifunctional ingredients for “natural and organic” sunscreens and photoprotective preparations, Molecules, 23(3), 664 (2018). DOI: https://doi.org/10.3390/molecules23030664
L.C. Cefali, J.G. Franco, G.F. Nicolini, J.A. Ataide, P.G. Mazzola,In vitro antio-xidant activity and solar protection factor of blackberry and raspberry extracts in topical formulation, J. Cosmet. Dermatol., 18(2), 539-544 (2019). DOI: https://doi.org/10.1111/jocd.12842
W.A.d.S. Almeida, A.d.S. Antunes, R.G. Penido, H.S.d.G. Correa, A.M.d. Nas-cimento, A.L. Andrade, et al., Photoprotective activity and increase of SPF in sunscreen formulation using lyophilized red propolis extracts from Alagoas, Braz. J. Pharmacogn., 29(3), 373-380 (2019). DOI: https://doi.org/10.1016/j.bjp.2019.02.003
C.L.F. de Almeida, S.A. Brito, T.I. de Santana, H.B.A. Costa, C.H.R. de Car-valho Júnior, M.V. Da Silva, et al., Spondias purpurea L. (Anacardiaceae): Antio-xidant and antiulcer activities of the leaf hexane extract, Oxid. Med.Cell. Longev., 2017, ID 6593073 (2017). DOI: https://doi.org/10.1155/2017/6593073
J.C. Mejía-Giraldo, R. Winkler, C. Gallardo, A.M. Sánchez-Zapata, M.A. Puer-tas-Mejía,Photoprotective potential of Baccharis antioquensis (Asteraceae) as natural sunscreen, Photochem. Photobiol., 92(5), 742-752 (2016). DOI: https://doi.org/10.1111/php.12619
A.D. Permana, R.N. Utami, A.J. Courtenay, M.A. Manggau, R.F. Donnelly, L. Rahman, Phytosomal nanocarriers as platforms for improved delivery of natu-ral antioxidant and photoprotective compounds in propolis: An approach for enhanced both dissolution behaviour in biorelevant media and skin retention profiles, J. Photochem.Photobiol. B, Biol., 205, 111846 (2020). DOI: https://doi.org/10.1016/j.jphotobiol.2020.111846
R.G. de Oliveira, G.R. Souza, A.L. Guimarães, A.P. de Oliveira, A.C. Silva-Morais, E.C. Da Cruz-Araújo, et al., Dried extracts of Encholirium spectabile (Bromeliaceae) present antioxidant and photoprotective activities in vitro, J. Young Pharm., 5(3), 102-105 (2013). DOI: https://doi.org/10.1016/j.jyp.2013.08.005
M.N. Alam, N.J. Bristi, M. Rafiquzzaman, Review on in vivo and in vitro methods evaluation of antioxidant activity, Saudi Pharm. J., 21(2), 143-152 (2013). DOI: https://doi.org/10.1016/j.jsps.2012.05.002
J.B.L. Tan, Y.Y. Lim, Critical analysis of current methods for assessing the in vitro antioxidant and antibacterial activity of plant extracts, Food Chem., 172, 814-822 (2015). DOI: https://doi.org/10.1016/j.foodchem.2014.09.141
A. Karadag, B. Ozcelik, S. Saner, Review of methods to determine antioxidant capacities, Food Anal. Methods, 2(1), 41-60 (2009). DOI: https://doi.org/10.1007/s12161-008-9067-7
P. Prieto, M. Pineda, M. Aguilar, Spectrophotometric quantitation of antioxi-dant capacity through the formation of a phosphomolybdenum complex: speci-fic application to the determination of vitamin E, Anal.Biochem., 269, 337-341 (1999). DOI: https://doi.org/10.1006/abio.1999.4019
T.A. de Sousa-Araújo, V.T.N. de Almeida e Castro, E.L.C. de Amorim, U.P. de Albuquerque, Habitat influence on antioxidant activity and tannin concentra-tions of Spondias tuberosa, Pharm. Biol., 50(6), 754-759 (2012). DOI: https://doi.org/10.3109/13880209.2011.630673
C.O. Medina,B.O. Louchard, T. Gonçalves, Análise espectrofotométrica da ati-vidade fotoprotetora in vitro de extratos das folhas de Byrsonima sericea, Rev. Cienc. Farm. Basic. Aplic., 36(3), 391-398 (2015).
L.P.G. Milani, N.O.S. Garcia, M.C. Morais, A.L.S. Dias, N.L. Oliveira, E.C. Conceição, Extract from byproduct Psidium guajava standardized in ellagic acid: additivation of the in vitro photoprotective efficacy of a cosmetic formula-tion, Braz. J. Pharmacogn., 28(6), 692-696 (2018). DOI: https://doi.org/10.1016/j.bjp.2018.08.005
J. Marto, L.F. Gouveia, B.G. Chiari, A. Paiva, V. Isaac, P. Pinto, et al., The green generation of sunscreens: Using coffee industrial sub-products, Ind.Crops Prod., 80, 93-100 (2016). DOI: https://doi.org/10.1016/j.indcrop.2015.11.033
T.B.S. Catelan, L. Gaiola, B.F. Duarte, C.A.L. Cardoso, Evaluation of the in vitro photoprotective potential of ethanolic extracts of four species of the genus Cam-pomanesia, J. Photochem. Photobiol. B, Biol., 197, 111500 (2019). DOI: https://doi.org/10.1016/j.jphotobiol.2019.04.009
D.M. Kasote, S.S. Katyare, M.V. Hegde, H. Bae, Significance of antioxidant potential of plants and its relevance to therapeutic applications, Int. J. Biol. Sci., 11(8), 982-991 (2015). DOI: https://doi.org/10.7150/ijbs.12096
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