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Aporte al desarrollo de un nanogel para la liberación controlada de latanoprost
Contribution to the development of a nanogel for the controlled release of latanoprost
Contribuição para o desenvolvimento de um nanogel para liberação controlada de latanoprost
DOI:
https://doi.org/10.15446/rcciquifa.v52n2.110754Keywords:
Nanogel , gelatina , latanoprost, emulsión-gelación , glaucoma (es)Nanogel, controlled release, latanoprost, ocular administration, glaucoma (en)
Nanogel, gelatina, latanoprost, emulsão-gelificação, glaucoma (pt)
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Introducción: el glaucoma es considerado como la segunda causa de ceguera en el mundo. El desarrollo de alternativas que brinden una mejor calidad de vida ha sido uno de los propósitos más importantes en el campo de las ciencias farmacéuticas. Los nanogeles debido a su alto contenido de agua y tamaño nanométrico son una alternativa adecuada para la administración ocular. Objetivo: diseñar un prototipo de nanogeles a base de gelatina mediante el método emulsión-gelación para la administración ocular de latanoprost, que fueron caracterizados por su tamaño y distribución de tamaños, capacidad de sorción, eficiencia de carga, propiedades viscoelásticas, isotonicidad y citotoxicidad. Resultados: se obtuvieron nanogeles con un tamaño entre 225 a 874 nm, un rendimiento entre 16-30%, una capacidad de sorción entre 22-46% y una eficiencia de carga del 58%. Adicionalmente, estos sistemas se ajustan a una cinética Korsmeyer Peppas. Las propiedades reológicas muestran un comportamiento viscoelástico con flujo pseudoplástico recomendable para lograr una residencia controlada en la conjuntiva y esclerótica del ojo. Los nanogeles obtenidos no fueron citotóxicos para fibroblastos e isotónicos. Conclusiones: los resultados obtenidos indican que los nanogeles con latanoprost son una alternativa en el tratamiento del glaucoma.
Introduction: Glaucoma is considered the second cause of blindness in the world. The development of alternatives that provide a better quality of life has been one of the most important purposes of pharmaceutical sciences. Due to their high-water content and nanometric size, nanogels are a suitable alternative for ocular administration. Aim: To design a prototype gelatin-based nanogel using the emulsion-gelation method for the ocular administration of latanoprost, characterized by their size and size distribution, sorption capacity, loading efficiency, viscoelastic properties, isotonicity, and cytotoxicity. Results: Nanogels with a size between 225 and 874 nm, a yield between 16-30%, a sorption capacity between 22-46%, and loading efficiency of 58% were obtained. Additionally, these systems conform to Korsmeyer-Peppa’s kinetics. The rheological properties show a viscoelastic behavior with a pseudoplastic flow that is recommended to achieve a controlled residence in the conjunctiva and sclera of the eye. The nanogels obtained were not cytotoxic for fibroblasts and were isotonic. Conclusions: The results obtained indicate that nanogels with latanoprost are an alternative in the treatment of glaucoma.
Introdução: o glaucoma é considerado a segunda causa de cegueira no mundo. O desenvolvimento de alternativas que proporcionem uma melhor qualidade de vida tem sido um dos propósitos mais importantes no campo das ciências farmacêuticas. Devido ao seu alto teor de água e tamanho nanométrico, os nanogéis são uma alternativa adequada para administração ocular. Objetivo: projetar um protótipo de nanogel à base de gelatina usando o método de emulsão-gelificação para administração ocular de latanoprost, que foram caracterizados por tamanho e distribuição de tamanho, capacidade de sorção, eficiência de carregamento, propriedades viscoelásticas, isotonicidade e citotoxicidade. Resultados: nanogéis com tamanho entre 225 a 874 nm, rendimento entre 16-30%, capacidade de sorção entre 22-46% e eficiência de carga de 58% foram obtidos. Além disso, esses sistemas estão em conformidade com a cinética de Korsmeyer Peppas. As propriedades reológicas mostram um comportamento viscoelástico com fluxo pseudoplástico que é recomendado para alcançar uma residência controlada na conjuntiva e esclera do olho. Os nanogéis obtidos foram não citotóxicos para fibroblastos e isotônicos. Conclusões: os resultados obtidos indicam que os nanogéis com latanoprost são uma alternativa no tratamento do glaucoma.
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