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Medicinal plants of the Verbenaceae family active against yeast fungi: Systematic review and perspectives 2015-2022
Plantas medicinales de la familia Verbenaceae activas frente a hongos levaduriformes: Revisión sistemática y perspectivas 2015-2022
Plantas medicinais da família Verbenaceae ativadas frente a hongos levaduriformes: Revisão sistemática e perspectivas 2015-2022
DOI:
https://doi.org/10.15446/rcciquifa.v53n2.114423Keywords:
Mycosis, medicinal plants, antifungal agents, plant extracts, essential oils, Verbenaceae (en)Infecciones micóticas, plantas medicinales, agentes antifúngicos, extractos vegetales, aceites esenciales, Verbenaceae (es)
Infecções micóticas, plantas medicinais, agentes antifúngicos, extratos vegetais, óleos essenciais, Verbenaceae (pt)
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Introduction: Opportunistic fungal infections have increased in recent decades, requiring the search for therapeutic alternatives, also considering the appearance of new species and the increase in resistance to antifungals. Objective: This study describes plants of the Verbenaceae family with therapeutic potential against yeast fungi. Methodology: A systematic review was carried from 2015 to 2020, using different databases, applying inclusion and exclusion criteria, also exploring recent perspectives to 2022. Results and discussion: 5 genera and 14 species with potential antifungal activity were found, highlighting the genus Lippia which showed greater activity. The essential oil of the leaves was the most studied natural product, mainly active against Candida albicans and Cryptococcus neoformans. Phytochemical analysis report mostly terpene-type metabolites such as carvacrol, thymol, linanol, and geraniol. For the determination of MIC, the in vitro technique of microdilution in broth was the most reported. Recent studies support the importance of species, including Lantana montevidensis (Spreng.) Briq., for their modulating activity of antifungal drugs. Conclusions: Five genera with potential activity were found: Aloysia, Lantana, Lippia, Stachytarpheta and Verbena; being of interest the species Lippia berlandieri Schauer and Lippia graveolens Kunth for its high activity against C. albicans and Cryptococcus neoformans. The importance of species of the Verbenaceae family for future research is recognized, which will allow the development of natural therapeutic alternatives against infections caused by yeast-like fungi.
Introducción: Las infecciones fúngicas oportunistas han aumentado en las últimas décadas requiriéndose la búsqueda de alternativas terapéuticas, considerando además la aparición de nuevas especies y el aumento de la resistencia a los antifúngicos. Objetivo: Este estudio describe plantas de la familia Verbenaceae con potencial terapéutico frente a hongos levaduriformes. Metodología: Se realizó una revisión sistemática de 2015 a 2020 empleando bases de datos, aplicando criterios de inclusión y exclusión, explorando además perspectivas recientes a 2022. Resultados y discusión: Se encontraron 5 géneros y 14 especies con potencial actividad antifúngica, resaltándose el género Lippia el cual demostró mayor actividad. El aceite esencial de hojas fue el producto natural más estudiado, principalmente activo frente a Candida albicans y Cryptococcus neoformans; los análisis fitoquímicos reportan en su mayoría metabolitos tipo terpeno como carvacrol, timol, linanol y geraniol. Para la determinación de CIM, la técnica in vitro de microdilución en caldo fue la más reportada. Estudios recientes respaldan la importancia de especies, entre ellas Lantana montevidensis (Spreng.) Briq., por su actividad moduladora de fármacos antifúngicos. Conclusión: Se encontraron cinco géneros con potencial actividad: Aloysia, Lantana, Lippia, Stachytarpheta y Verbena; siendo de interés las especies Lippia berlandieri Schauer y Lippia graveolens Kunth por su alta actividad frente a C. albicans y C. neoformans. Se reconoce la importancia de especies de la familia Verbenaceae para futuras investigaciones, que permitan desarrollar alternativas terapéuticas naturales contra infecciones causadas por hongos levaduriformes.
Introdução: As infecções fúngicas oportunistas aumentaram nas últimas décadas, exigindo a busca de alternativas terapêuticas, considerando também o aparecimento de novas espécies e o aumento da resistência aos antifúngicos. Objetivo: Este estudo descreve plantas da família Verbenaceae com potencial terapêutico frente a grandes levaduriformes. Metodologia: Foi realizada uma revisão sistemática de 2015 a 2020, empregando bases de dados, aplicando critérios de inclusão e exclusão, explorando outras perspectivas recentes para 2022. Resultados e discussão: Encontrar 5 gêneros e 14 espécies com potencial atividade antifúngica, resaltando o gênero Lippia el cual demostró mayor actividad. O óleo essencial de folhas de chá foi o produto natural mais estudado, principalmente ativo contra Candida albicans e Cryptococcus neoformans; a análise fitoquímica relatada em seus principais metabólitos, como terpeno, como carvacrol, timol, linanol e geraniol. Para a determinação do CIM, a técnica de microdiluição in vitro em caldo foi mais relatada. Estudos recentes respaldaram a importância das espécies, entre elas Lantana montevidensis (Spreng.) Briq., por sua atividade moduladora de medicamentos antifúngicos. Conclusão: Foram encontrados cinco gêneros com atividade potencial: Aloysia, Lantana, Lippia, Stachytarpheta e Verbena; sendo de interesse as espécies Lippia berlandieri Schauer e Lippia graveolens Kunth por sua alta atividade frente a C. albicans e C. neoformans. Se você reconhecer a importância das espécies da família Verbenaceae para futuras investigações, permitirá desenvolver alternativas terapêuticas naturais contra infecções causadas por fungos levaduriformes.
References
Y. Schmiedel, S. Zimmerli, Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia,
Swiss Medical Weekly, 146, w14281 (2016). Doi: https://doi.org/10.4414/smw.2016.14281
S. Vallabhaneni, R.K. Mody, T. Walker, T. Chiller, The global burden of fungal diseases, Infectious Disease Clinics of North America, 30(1), 1-11 (2016). Doi: https://doi.org/10.1016/j.idc.2015.10.004
O.T. Ezeokoli, O. Gcilitshana, C.H. Pohl, Risk factors for fungal co-infections in critically ill COVID-19 patients, with a focus on immunosuppressants, Journal of Fungi, 7(7), 545 (2021). Doi: https://doi.org/10.3390/jof7070545
G. Segrelles-Calvo, G.R. de Araújo, S. Frases, Systemic mycoses: a potential alert for complications in COVID-19 patients, Future Microbiology, 15(14), 1405-1413 (2020). Doi: https://doi.org/10.2217/fmb-2020-0156
S. Zurita, Situation of anti-fungal resistance of species of the genus Candida in Peru, Revista Peruana de Medicina Experimental y Salud Pública, 35(1), 126-131 (2018). Doi: https://doi.org/10.17843/rpmesp.2018.351.3563
J.A. Cortés, P. Reyes, C.H. Gómez, S.I. Cuervo, P. Rivas, C.A. Casas, et al., Clinical and epidemiological characteristics and risk factors for mortality in patients with candidemia in hospitals from Bogotá, Colombia, The Brazilian Journal of Infectious Diseases, 18(6), 631-637 (2014). Doi: https://doi.org/10.1016/j.bjid.2014.06.009
R. Selb, V. Fuchs, B. Graf, A. Hamprecht, M. Hogardt, L. Sedlacek, R. Sánchez, Molecular typing and in vitro resistance of Cryptococcus neoformans clinical isolates obtained in Germany between 2011 and 2017, Int. J. Med. Microbiol., 309(6), 1-8 (2019). Doi: https://doi.org/10.1016/j.ijmm.2019.151336
F. Bongomin, R.O. Oladele, S. Gago, C.B. Moore, M.D. Richardson, A systematic review of fluconazole resistance in clinical isolates of Cryptococcus species, Mycoses, 61(5), 290-297 (2018). Doi: https://doi.org/10.1111/myc.12747
S.R. Lockhart, J. Guarner, Emerging and reemerging fungal infections, Seminars in Diagnostic Pathology, 36(3), 177-181 (2019). Doi: https://doi.org/10.1053/j.semdp.2019.04.010
M. Nucci, G. Barreiros, L.F. Guimarães, V.A.S. Deriquehem, A.C. Castiñeiras, S.A. Nouér, Increased incidence of candidemia in a tertiary care hospital with the COVID-19 pandemic, Mycoses, 64(2), 152-156 (2021). Doi: https://doi.org/10.1111/myc.13225
A. Chowdhary, B. Tarai, A. Singh, A. Sharma, Multidrug-resistant Candida auris infections in critically ill coronavirus disease patients, India, April–July 2020, Emerg. Infectious Diseases, 26(11), 2694-2696 (2020). Doi: https://doi.org/10.3201/eid2611.203504
B. Posteraro, R. Torelli, A. Vella, P.M. Leone, G. De Angelis, E. De Carolis, G. Ventura, M. Sanguinetti, M. Fantoni, Pan-echinocandin-resistant Candida glabrata bloodstream infection complicating COVID-19: A fatal case report, Journal of Fungi, 6(3), 163-174 (2020). Doi: https://doi.org/10.3390/jof6030163
I. Quiles, J. Garc.a, Antif.ngicos de uso sist.mico, Revista Iberoamericana de Micolog.a, 38(2), 42-46 (2021). Doi: https://doi.org/10.1016/j.riam.2021.04.004
A. Rasool, K.M. Bhat, A.A. Sheikh, A. Jan, S. Hassan, Medicinal plants: Role, distribution and future, Journal of Pharmacognosy and Phytochemistry, 9(2), 2111-2114 (2020). URL: https://www.phytojournal.com/archives/2020.v9.i2.11165/medicinal-plants-role-distribution-and-future
C.C. Achilonu, O.U. Udensi, Systematic review of antimicrobial activities of medicinal plants against bacterial and fungal microbes: a research trend in Africa from 1980 to 2019, Research Square, 1-22 (2022). Doi: https://doi.org/10.21203/rs.3.rs-1529001/v1
A.M. Viljoen, S. Subramoney, S.F. van Vuuren, K.H.C Başer, B. Demirci, The composition, geographical variation and antimicrobial activity of Lippia javanica (Verbenaceae) leaf essential oils, Journal of Ethnopharmacology, 96(1-2), 271-277 (2005). Doi: https://doi.org/10.1016/j.jep.2004.09.017
A. Muñoz-Acevedo, M.C. González, O.J. Castillo, C.P, Guzmán, S. Rodríguez-Acosta, M. Cervantes-Díaz, et al., Promising antimicrobial agents from some Latin American medicinal plants against disease-causing pathogens in humans and animals, en: M. Rai, I. Kosalec (editores), Promising Antimicrobials from Natural Products, Springer, Cham, Switzerland, 2022, pp. 241-279. URL: https://link.springer.com/chapter/10.1007/978-3-030-83504-0_11
L. Betancur-Galvis, B. Zapata, A. Baena, J. Bueno, C.A. Ruíz-Nova, E. Stashenko, A.C. Mesa-Arango, Antifungal, cytotoxic and chemical analyses of essential oils of Lippia origanoides HBK grown in Colombia, Revista Salud UIS, 43(2), 141-148 (2011). URL: https://revistas.uis.edu.co/index.php/revistasaluduis/article/view/2397
J. Henao, L.J. Muñoz, E. Ríos, L. Padilla, G.A. Giraldo, Evaluación de la actividad antimicrobiana de los extractos de la planta Lippia origanoides H.B.K. cultivada en el Departamento del Quindío, Revista de Investigaciones Universidad del Quindío, 19(1), 159–164 (2009). Doi: https://doi.org/10.33975/riuq.vol19n1.784
C.M. Pérez-Zamora, C.A. Torres, M.B. Nuñez, Antimicrobial activity and chemical composition of essential oils from Verbenaceae species growing in South America, Molecules, 23(3), 544 (2018). Doi: https://doi.org/10.3390/molecules23030544
Z. Xu, L. Chang, Verbenaceae, en: Identification and Control of Common Weeds, Vol. 3, Springer Netherlands, Dordrecht, 2017, p. 163. Doi: https://doi.org/10.1007/978-981-10-5403-7_7
E.O. Sousa, F.S.S. Barreto, F.F.G. Rodrigues, A.R. Campos, J.G.M. Costa, Chemical composition of the essential oils of Lantana camara L. and Lantana montevidensis Briq. and their synergistic antibiotic effects on aminoglycosides, Journal of Essential Oil Research, 24(5), 447-452 (2012). Doi: https://doi.org/10.1080/10412905.2012.703494
U. Nogueira de Aguiar, S.G. de Lima, M.d.S. Rocha, A.M.d.G. Lopes-Citó, A.J. Pereira-Sousa, R. Morais-Silva, I.S. Alcantara-Silva, J.G. Martins da Costa, Chemical composition and modulation of antibiotic activity of essential oil of Lantana caatingensis M. (Verbenaceae), Industrial Crops and Products, 74, 165-170 (2015). Doi: https://doi.org/10.1016/j.indcrop.2015.04.011
C.M. Pérez-Zamora, C.A. Torres, M.I. Aguado, A.J. Bela, M.B. Nuñez, C. Bregni, Actividad antibacteriana de los aceites esenciales de Aloysia polystachya y Lippia turbinata (Verbenaceae), Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 15(4), 199-205 (2016). URL: https://www.blacpma.ms-editions.cl/index.php/blacpma/article/view/274
T.G. Santos, J. Laemmle, R.A. Rebelo, E.M. Dalmarco, B. Cruz, A.P. Schmit, A.L.B. Zeni, Chemical composition and antimicrobial activity of Aloysia gratissima (Verbenaceae) leaf essential oil, Journal of Essential Oil Research, 27(2), 125-130 (2015). Doi: https://doi.org/10.1080/10412905.2015.1006737
J. Acero-Godoy, T. Guzmán-Hernández, C. Muñoz-Ruiz, Revisión documental de uso de los aceites esenciales obtenidos de Lippia alba (Verbenaceae), como alternativa antibacteriana y antifúngica, Revista Tecnología en Marcha, 32(1), 3-11 (2019). URL: https://www.scielo.sa.cr/pdf/tem/v32n1/0379-3982-tem-32-01-3.pdf
V. Tangarife-Castaño, J. Correa-Royero, B. Zapata-Londoño, C. Durán, E. Stashenko, A.C. Mesa-Arango, Anti-Candida albicans activity, cytotoxicity and interaction with antifungal drugs of essential oils and extracts from aromatic and medicinal plants, Infectio, 15(3), 160-167 (2011). Doi: https://doi.org/10.1016/S0123-9392(11)70080-7
A.K. Pardo, J.J. Arenas, M. Gómez, F.M. Lora, J.E. Gómez, Determinación de la actividad antifúngica de extractos de Lantana camara frente a Candida spp., Infectio, 15(4), 235-242 (2011). Doi: https://doi.org/10.1016/S0123-9392(11)70737-8
S.E. Giraldo-Quintero, M.C. Bernal-Lizarazú, A. Morales-Robayo, A.Z. Pardo-Lobo, L. Gamba-Molano, Descripción del uso tradicional de plantas medicinales en mercados populares de Bogotá, D.C., Nova, 13(23), 73-80 (2015). Doi: https://doi.org/10.22490/24629448.1707
N.A. Navarrete-Barragán, E.F. Pita-Ospina, R.M. Sánchez-Mora, S.E. Giraldo-Quintero, M.C. Bernal-Lizarazú, Actividad in vitro de los extractos etanólicos de Lantana camara L., Petiveria alliacea L. y Lippia dulcis T. frente a bacterias patógenas, Nova, 18(33), 53-71 (2020). Doi: https://doi.org/10.22490/24629448.3700
L.R. Jaimes-Duarte, J.F. Hoyos-Argote, Plantas medicinales de la familia Verbenaceae con potencial antifúngico contra hongos levaduriformes, Trabajo de grado, Universidad de la Salle, Bogotá D.C., 2020. 54 p. URL: https://ciencia.lasalle.edu.co/biologia/91
M.K. Swamy, M.S. Akhtar, U.R. Sinniah, Antimicrobial properties of plant essential oils against human pathogens and their mode of action: An updated review, Evidence-Based Complementary and Alternative Medicine, 2016, 3012462, (2016). Doi: https://doi.org/10.1155/2016/3012462
E.E. Elemike, D.C. Onwudiwe, A.C. Ekennia, R.C. Ehiri, N.J. Nnaji, Phytosynthesis of silver nanoparticles using aqueous leaf extracts of Lippia citriodora: Antimicrobial, larvicidal and photocatalytic evaluations, Materials Science and Engineering: C, 75, 980-989 (2017). Doi: https://doi.org/10.1016/j.msec.2017.02.161
A.B. Miller, R.G. Cates, M. Lawrence, J.A.F. Soria, L.V. Espinoza, J.V. Martinez, D.A. Arbizú, The antibacterial and antifungal activity of essential oils extracted from Guatemalan medicinal plants, Pharmaceutical Biology, 53(4), 548-554 (2015). Doi: https://doi.org/10.3109/13880209.2014.932391
P.M. Liew, Y.K. Yong, Stachytarpheta jamaicensis (L.) Vahl: from traditional usage to pharmacological evidence, Evidence-Based Complementary and Alternative Medicine, 2016, 7842340 (2016). Doi: https://doi.org/10.1155/2016/7842340
F. Reyes-Jurado, T. Cervantes-Rincón, H. Bach, A. López-Malo, E. Palou, Antimicrobial activity of Mexican oregano (Lippia berlandieri), thyme (Thymus vulgaris), and mustard (Brassica nigra) essential oils in gaseous phase, Industrial Crops and Products, 13, 90-95 (2019). Doi: https://doi.org/10.1016/j.indcrop.2019.01.036
A. Sartoratto, A.L.M. Machado, C. Delarmelina, G.M. Figueira, M.C.T. Duarte, V.L.G. Rehder, Composition and antimicrobial activity of essential oils from aromatic plants used in Brazil, Brazilian Journal of Microbiology, 35(4), 275-280 (2004). Doi: https://doi.org/10.1590/S1517-83822004000300001
W. Sales de Almeida, S.G. de Lima, H. Medeiros-Barreto, L.M. de Sousa-Andrade, L. Fonseca, C. Athayde-Sobrinho, A.R. Beserra-Santos, M.C. Sanches-Muratori, Chemical composition and antimicrobial activity of the essential oil of Lippia lasiocalycina Cham. (Verbenaceae), Industrial Crops and Products, 125, 236-240 (2018). Doi: https://doi.org/10.1016/j.indcrop.2018.09.007
N. Santos, R.C. Pascon, M.A. Vallim, C.R. Figueiredo, M.G. Soares, J.H.G. Lago, P. Sartorelli, Cytotoxic and antimicrobial constituents from the essential oil of Lippia alba (Verbenaceae), Medicines, 3(3), 22 (2016). Doi: https://doi.org/10.3390/medicines3030022
S. Córdoba, W. Vivot, W. Szusz, G. Albo, Antifungal activity of essential oils against Candida species isolated from clinical samples, Mycopathologia, 184(5), 615-623 (2019). Doi: https://doi.org/10.1007/s11046-019-00364-5
C. Scotto, P. Burger, M. Khodjet, M. Ginouves, G. Prevot, D. Blanchet, P.G. Delprete, X. Fernandez, Corrigendum of the article: Composition and antifungal activity of the essential oil of Nashia inaguensis Millsp. (Verbenaceae) cultivated in French Guiana, Journal of Essential Oil Research, 29(6), 507-509 (2017). Doi: https://doi.org/10.1080/10412905.2017.1369466
W.H. Perera, H.R. Bizzo, P.E. Gama, C.S. Alviano, F.R.G. Salimena, D.S. Alviano, S.G. Leitão, Essential oil constituents from high altitude Brazilian species with antimicrobial activity: Baccharis parvidentata Malag., Hyptis monticola Mart. ex Benth. and Lippia origanoides Kunth, Journal of Essential Oil Research, 29(2), 109-116 (2016). Doi: https://doi.org/10.1080/10412905.2016.1210039
D.I.V. Brito, M.F. Morais-Braga, F.A.B. Cunha, R.S. Albuquerque, J.N.P Carneiro, M.S. Lima, N.F. Leite, C.E.S. Souza, J.C. Andrade, L.B.B. Alencar, A.K.L.S. Lavor, F.G. Figueredo, L.F. Lima, H.D.M. Coutinho, Análise fitoquímica e atividade antifúngica do óleo essencial de folhas de Lippia sidoides Cham. e do Timol contra cepas de Candida spp., Revista Brasileira de Plantas Medicinais (Campinas), 17(4), 836-844 (2015). Doi: https://doi.org/10.1590/1983-084X/14_060
E.E. Essien, T.M. Walker, J.S. Newby, W.N. Setzer, O. Ekundayo, Characterization and antimicrobial activity of essential oils of Stachytarpheta indica (Linn.) Vahl and Mariscus alternifolius Vahl, Journal of Medicinally Active Plants, 5(2), 47-52 (2017). Doi: https://doi.org/10.7275/R5DR2SNN
S.R. De Morais, T.L.S. Oliveira, L.P. De Oliveira, L.M. Faustino, E. Cardoso, M.H. Rezende, T.d.S. Fiuza, E.A. Costa, P.H. Ferri, J.R. de Paula, Essential oil composition, antimicrobial and pharmacological activities of Lippia sidoides Cham. (Verbenaceae) from São Gonçalo do Abaeté, Minas Gerais, Brazil, Pharmacognosy Magazine, 12(48), 262-270 (2016). URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096271/pdf/PM-12-262.pdf
M.V.N. Mbunde, F. Mabiki, E. Innocent, P.G. Andersson, Antifungal activity of single and combined extracts of medicinal plants from Southern Highlands of Tanzania, Journal of Pharmacognosy and Phytochemistry, 8(1), 181-187 (2019). URL: https://www.phytojournal.com/archives?year=2019&vol=8&issue=1&ArticleId=6722
A. Teka, J. Rondevaldova, Z. Asfaw, S. Demissew, P. Van Damme, L. Kokoska, W. Vanhove, In vitro antimicrobial activity of plants used in traditional medicine in Gurage and Silti Zones, south central Ethiopia, BMC Complementary Medicine and Therapies, 15, 286 (2017). Doi: https://doi.org/10.1186/s12906-015-0822-1
M. Ghasempour, S.M. Omran, A.A. Moghadamnia, F. Shafiee, Effect of aqueous and ethanolic extracts of Lippia citriodora on Candida albicans, Electronic Physician, 8(8) 2752-2758 (2016). Doi: https://doi.org/10.19082/2752
G. Lara-Issasi, C. Salgado, J. Pedraza-Chaverri, O.N. Medina-Campos, A. Morales, M.A. Águila, M. Avilés, B.E. Rivero-Cruz, V. Navarro, R. Ríos-Gómez, M.I. Aguilar, Antimicrobial, antioxidant activities, and HPLC determination of the major components of Verbena carolina (Verbenaceae), Molecules, 24(10), 1970 (2019). Doi: https://doi.org/10.3390/molecules24101970
S. Herrera, R. López, E. García, M. Estarrón, Mexican oregano (Lippia graveolens) essential oil-in-water emulsions: impact of emulsifier type on the antifungal activity of Candida albicans, Food Science and Biotechnology, 28, 441-448 (2019). Doi: https://doi.org/10.1007/s10068-018-0499-6
R.C. dos Santos, A.A. de Melo Filho, E.A. Chagas, J.A. Takahashi, V.P Ferraz, I.M. Fernandez, P.R.E. Ribeiro, A.C.G. Reis de Melo, L.C. Holanda, Chemical composition, antimicrobial and anti-acetylcholinesterase activities of essential oil from Lantana camara (Verbenaceae) flowers, Journal of Medicinal Plants Research, 9(35), 922-928 (2015). Doi: https://doi.org/10.5897/JMPR2015.5919
L. Rezig, M. Saada, N. Trabelsi, S. Tammar, H. Limam, I. Bettaieb-Rebey, A. Smaoui, G. Sghaier, G. Del Re, R. Ksouri, K. Msaada, Chemical composition, antioxidant and antimicrobial activities of Aloysia triphylla L. Essential oils and methanolic extract, Italian Journal of Food Science, 31(3), 556-572 (2019). Doi: https://doi.org/10.14674/IJFS-1373
C. Giordani, R. Santin, M.B. Cleff, Levantamento de extratos vegetais com ação anti-Candida no período de 2005-2013, Revista Brasileira de Plantas Medicinais, (Campinas), 17(1), 175-185 (2015). Doi: https://doi.org/10.1590/1983-084X/12_072
Y.O. Hay, M.A. Abril-Sierra, L.G. Sequeda-Castañeda, C. Bonnafous, C. Raynaud, Evaluation of combinations of essential oils and essential oils with hydrosols on antimicrobial and antioxidant activities, Journal of Pharmacy & Pharmacognosy Research, 6(3), 216-230 (2018). Doi: https://doi.org/10.56499/jppres17.310_6.3.216
Y. Pájaro-González, A.F. Oliveros-Díaz, J. Cabrera-Barraza, J. Cerra-Dominguez, F. Díaz-Castillo, F, Chapter 1 - A review of medicinal plants used as antimicrobials in Colombia, en: F. Chassagne (editor), Medicinal Plants as Anti-Infectives, Academic Press, Toulouse, 2022, p. 3-57. Doi: https://doi.org/10.1016/B978-0-323-90999-0.00005-7
E. Stashenko, J.R Martínez, Chapter 8. Study of essential oils obtained from tropical plants grown in Colombia, en: H. El-Shemy (editor), Essential oils: oils of nature, IntechOpen Limited, London, 2019, p. 1-28. Doi: https://doi.org/10.5772/intechopen.87199
J. Correa-Royero, V. Tangarife, C. Durán, E. Stashenko, A. Mesa-Arango, In vitro antifungal activity and cytotoxic effect of essential oils and extracts of medicinal and aromatic plants against Candida krusei and Aspergillus fumigatus, Revista Brasileira de Farmacognosia, 20(5), 734-741 (2010). Doi: https://doi.org/10.1590/S0102-695X2010005000021
A.L. Bandoni, D. Retta, P.M.D.L. Lira, C.M. van Baren, ¿Son realmente útiles los aceites esenciales?, Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 8(5), 317-322 (2009). URL: https://www.redalyc.org/pdf/856/85611977001.pdf
P.S. Costa, E.B. de Souza, E.H. Salles, R.O. dos Santos, Atividade antimicrobiana e potencial terapêutico do gênero Lippia sensu lato (Verbenaceae), Hoehnea, 44(2), 158-171 (2017). Doi: https://doi.org/10.1590/2236-8906-68/2016
T. Vila, J.A. Romo, C.G. Pierce, S.F. McHardy, S.P. Saville, J.L. Lopez-Ribot, Targeting Candida albicans filamentation for antifungal drug development, Virulence, 8(2), 150-158 (2017). Doi: https://doi.org/10.1080/21505594.2016.1197444
V.K. Chin, T.Y. Lee, B. Rusliza, P.P. Chong, Dissecting Candida albicans infection from the perspective of C. albicans virulence and omics approaches on host–pathogen interaction: A review, Internationl Journal of Molecular Sciences, 17(10), 1643 (2016). Doi: https://doi.org/10.3390/ijms17101643
R. Pérez-Torrado, A. Querol, Opportunistic strains of Saccharomyces cerevisiae: A potential risk sold in food products, Frontiers in Microbiology, 6, 1522 (2016). Doi: https://doi.org/10.3389/fmicb.2015.01522
M. Balouiri, M. Sadiki, S.K. Ibnsouda, Methods for in vitro evaluating antimicrobial activity: A review, Journal of Pharmaceutical Analysis, 6(2), 71-79 (2016). Doi: https://doi.org/10.1016/j.jpha.2015.11.005
L. Scorzoni, F. Sangalli-Leite, J.de Lacorte-Singulani, A.C.A. de Paula e Silva, C.B. Costa-Orlandi, A.M. Fusco-Almeida, M.J.S. Mendes-Giannini, Searching new antifungals: The use of in vitro and in vivo methods for evaluation of natural compounds, Journal of Microbiological Methods, 123, 68-78 (2016). Doi: https://doi.org/10.1016/j.mimet.2016.02.005
N. Vaou, E. Stavropoulou, C. Voidarou, C. Tsigalou, E. Bezirtzoglou, Towards advances in medicinal plant antimicrobial activity: A review study on challenges and future perspectives, Microorganisms, 9(10), 2041 (2021). Doi: https://doi.org/10.3390/microorganisms9102041
I. Bautista-Hernández, C.N. Aguilar, G.C.G. Martínez-Ávila, C. Torres-León, A. Ilina, A. C. Flores-Gallegos, D.K. Verma, M.L. Chávez-González, Mexican oregano (Lippia graveolens Kunth) as source of bioactive compounds: A review, Molecules, 26(17), 5156 (2021). Doi: https://doi.org/10.3390/molecules26175156
N. Jaradat, M. Hawash, M.N. Abualhasan, M. Qadi, M. Ghanim, E. Massarwy, S.A. Ammar, N. Zmero, M. Arar, F. Hussein, L. Issa, A. Mousa, A. Zarour, Spectral characterization, antioxidant, antimicrobial, cytotoxic, and cyclooxygenase inhibitory activities of Aloysia citriodora essential oils collected from two Palestinian regions, BMC Complementary Medicine and Therapies, 21, 143 (2021). Doi: https://doi.org/10.1186/s12906-021-03314-1
J.d.L. Silva, P.S. Pereira, C.V. Barros-Oliveira, M.A. de Freitas, J.R. de Lima-Silva, A. Rodrigues-Costa, C.D.d.M. Oliveira-Tintino, M.F.B. Morais-Braga, A.E. Duarte, H.D. Melo-Coutinho, L.M. Barros, Study of the capacity of the essential oil of Lantana montevidensis to modulate the action of fluconazole on Candida albicans and Candida tropicalis strains, Journal of Medical Mycology, 31(3), 101171 (2021). Doi: https://doi.org/10.1016/j.mycmed.2021.101171
H.Y. Bernal, H. García-Martínez, G.F. Quevedo-Sánchez, Pautas para el conocimiento, conservación y uso sostenible de las plantas medicinales nativas en Colombia. Estrategia Nacional para la Conservación de Plantas, Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Bogotá, 2011, 236 p. URL: http://repository.humboldt.org.co/handle/20.500.11761/31427
C.M. Lozano, M.A. Vasquez-Tineo, M. Ramírez, M.I. Infante, In vitro antimicrobial activity of tropical medicinal plants used in Santo Domingo, Dominican Republic: Part 2, Pharmacognosy Communications, 11(1), 52-60 (2021). Doi: https://doi.org/10.5530/pc.2021.1.11
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