Modelos en desarrollo de terapias derivadas de biotecnologia

Gustavo Jaimes Monroy

Published

2007-01-01

Modelos en desarrollo de terapias derivadas de biotecnologia

Models on the development of therapies derived from biotechnology

Keywords:

ARN de interferencia, terapia antisentido, ribozimas, aptámeros, oligonucleótidos formadores de hélices triples, señuelos (es)
Interference RNA, antisense therapy, ribozymes, aptamers, oligonucleotides triplex helix formers, decoys. (en)

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Authors

Gustavo Jaimes Monroy

Abstract (es)
Abstract (en)

El objetivo de la terapia génica para el tratamiento del cáncer es eliminar las células tumorales preservando el tejido normal. Diversas estrategias para llevar acabo este objetivo han demostrado resultados promisorios en el laboratorio, incluyendo moléculas que pueden tener blancos específicamente predeterminados en secuencias en el ADN y el ARNm; estas secuencias proporcionan un medio para modular la función de genes endógenos. Diferentes tipos de moléculas: inductores de hélices triples, oligodeoxinucleótidos antisentido, ribozimas, ARN de interferencia, aptámeros y señuelos son revisados en este documento.

The objective of gene therapy for the treatment of cancer is to kill tumor cells but preserve normal tissue. A variety of strategies to achieve these aims have demonstrated promising results in the laboratory, including molecules that can specifically target pre-determined sequences in the DNA or RNAm; that sequences provide a means to modulate endogenous gene function. The different types of molecules: triplex forming molecules, antisense oligodeoxynucleotides, ribozymes, RNA interference, aptamers and decoys, are reviewed in this paper.

How to Cite

APA

Jaimes Monroy, G. (2007). Modelos en desarrollo de terapias derivadas de biotecnologia. Revista Colombiana de Ciencias Químico-Farmacéuticas, 36(1). https://revistas.unal.edu.co/index.php/rccquifa/article/view/1568

ACM

[1]

Jaimes Monroy, G. 2007. Modelos en desarrollo de terapias derivadas de biotecnologia. Revista Colombiana de Ciencias Químico-Farmacéuticas. 36, 1 (Jan. 2007).

ACS

(1)

Jaimes Monroy, G. Modelos en desarrollo de terapias derivadas de biotecnologia. Rev. Colomb. Cienc. Quím. Farm. 2007, 36.

ABNT

JAIMES MONROY, G. Modelos en desarrollo de terapias derivadas de biotecnologia. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 36, n. 1, 2007. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/1568. Acesso em: 22 jan. 2025.

Chicago

Jaimes Monroy, Gustavo. 2007. “Modelos en desarrollo de terapias derivadas de biotecnologia”. Revista Colombiana De Ciencias Químico-Farmacéuticas 36 (1). https://revistas.unal.edu.co/index.php/rccquifa/article/view/1568.

Harvard

Jaimes Monroy, G. (2007) “Modelos en desarrollo de terapias derivadas de biotecnologia”, Revista Colombiana de Ciencias Químico-Farmacéuticas, 36(1). Available at: https://revistas.unal.edu.co/index.php/rccquifa/article/view/1568 (Accessed: 22 January 2025).

IEEE

[1]

G. Jaimes Monroy, “Modelos en desarrollo de terapias derivadas de biotecnologia”, Rev. Colomb. Cienc. Quím. Farm., vol. 36, no. 1, Jan. 2007.

MLA

Jaimes Monroy, G. “Modelos en desarrollo de terapias derivadas de biotecnologia”. Revista Colombiana de Ciencias Químico-Farmacéuticas, vol. 36, no. 1, Jan. 2007, https://revistas.unal.edu.co/index.php/rccquifa/article/view/1568.

Turabian

Jaimes Monroy, Gustavo. “Modelos en desarrollo de terapias derivadas de biotecnologia”. Revista Colombiana de Ciencias Químico-Farmacéuticas 36, no. 1 (January 1, 2007). Accessed January 22, 2025. https://revistas.unal.edu.co/index.php/rccquifa/article/view/1568.

Vancouver

1.

Jaimes Monroy G. Modelos en desarrollo de terapias derivadas de biotecnologia. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 2007 Jan. 1 [cited 2025 Jan. 22];36(1). Available from: https://revistas.unal.edu.co/index.php/rccquifa/article/view/1568

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