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Actividad antinociceptiva de triterpenos aislados de Clusia ellipticifolia
Antinociceptive activity of triterpenes isolated from Clusia ellipticifolia
Keywords:
Clusia ellipticifolia – Guttiferae – Ácido betulinico – Friedelinol – Friedelina – Actividad antinociceptiva. (es)Clusia ellipticifolia – Guttiferae - Betulinic acid – Friedelinol – Friedeline - Antinociceptive activity. (en)
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Con base en los usos tradicional de varias especies de la familia Guttiferae, tres compuestos fueron aislados del extracto metabólico de la corteza de Clusia ellipticifolia y identificados por medio de métodos químicos y espectroscópicos como ácid betulinico, friedelinol and friedelina. El estudio farmacológico por el modelo de contorsiones abdominales inducidas por ácido acético mostró actividad antinociceptiva muy significante para los compuestos aislados siendo la mas alta fue atribuida al ácido betulinico.
On the base of the traditional use, from the methanolic extract of the stem bark of Clusia ellipticifolia of the family Guttiferae, three pure triterpenoid compounds were isolated and identified as betulinic acid, friedelinol and friedeline, by means of chemical and spectroscopic methods. The pharmacological study by the abdominal contortions model induced by acetic acid showed significant antinociceptive activities to the studied substances and the highest effect was attributed to the betulinic acid.
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Copyright (c) 2004 Revista Colombiana de Ciencias Químico-Farmacéuticas
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