Published

2019-09-01

A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design

Un prototipo de solución espumante de bajo costo para la limpieza de párpados y el manejo de síntomas en pacientes con blefaritis crónica: un diseño de mezcla I-óptimo

DOI:

https://doi.org/10.15446/rcciquifa.v48n3.84982

Keywords:

Blepharitis, mixture design, I-optimal, foaming solutions, tea tree oil, sodium lauryl sulfate (en)
Blefaritis, diseño de mezcla, diseño I-óptimo, solución espumosa, aceite de árbol de té, lauril sulfato sódico (es)

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Authors

  • Francisco Javier Burgos-Flórez Department of Mechanical Engineering, Rational use of energy and environment preservation Group (UREMA), Universidad del Norte, Barranquilla
  • Roxana de las Salas Department of Nursing, Nursing Research Group, Universidad del Norte, Barranquilla
lepharitis is a common chronic eye condition that causes eyelid inflammation, leading to inflamed, irritated, sticky and itchy eyelids and flaking of the skin. For its treatment, patients often need indefinite use of an eyelid cleaning solution which usually cost more than 20 USD per 80 ml bottle and lasts, on average, one month. For those patients unable to afford the treatment, physicians recommend the use of a do it yourself (DIY) solution. However, the efficacy of DIY eyelid solutions might fluctuate according to the type of blepharitis present in the patient and inadequate pH stabilization of the solution might promote additional itchiness, irritation, and dryness of the skin and eyes. Thus, we propose an optimized DIY solution prototype for symptom management in patients with chronic blepharitis. The formulation contains a significant ratio of tea tree oil and resulted in suitable pH and foam expansion values. The low cost and ease of preparation of the designed formulation make it an affordable, effective alternative in the treatment of chronic blepharitis.

La blefaritis crónica es una condición ocular que causa inflamación en los párpados, dando como resultado párpados irritados, pegadizos y descamación de la piel. Pacientes con esta condición necesitan usualmente de la aplicación de una solución de limpieza de párpados que cuesta en promedio 20 USD por cada 80 ml de solución y tiene un rendimiento de un mes. Para aquellos pacientes incapaces de costear el tratamiento, los médicos recomiendan el uso de soluciones hazlo tú mismo (DIY en inglés). Sin embargo, la eficacia de estas en el tratamiento de la condición puede fluctuar de acuerdo con el tipo de blefaritis presente. Adicionalmente, una inadecuada estabilización del pH de la solución puede promover una mayor irritación, resequedad y picazón en la piel y en los ojos. Por lo tanto, en este trabajo proponemos un prototipo experimental de solución DIY para el manejo sintomático de pacientes con blefaritis crónica. La formulación contiene una proporción significativa de aceite de árbol de té y posee un pH adecuado y alta producción de espuma para su correcta aplicación en la piel. El bajo costo y facilidad de preparación hacen de ella una alternativa efectiva y asequible en el tratamiento de la blefaritis crónica.

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How to Cite

APA

Burgos-Flórez, F. J. and de las Salas, R. (2019). A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design. Revista Colombiana de Ciencias Químico-Farmacéuticas, 48(3). https://doi.org/10.15446/rcciquifa.v48n3.84982

ACM

[1]
Burgos-Flórez, F.J. and de las Salas, R. 2019. A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design. Revista Colombiana de Ciencias Químico-Farmacéuticas. 48, 3 (Sep. 2019). DOI:https://doi.org/10.15446/rcciquifa.v48n3.84982.

ACS

(1)
Burgos-Flórez, F. J.; de las Salas, R. A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design. Rev. Colomb. Cienc. Quím. Farm. 2019, 48.

ABNT

BURGOS-FLÓREZ, F. J.; DE LAS SALAS, R. A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 48, n. 3, 2019. DOI: 10.15446/rcciquifa.v48n3.84982. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/84982. Acesso em: 8 mar. 2025.

Chicago

Burgos-Flórez, Francisco Javier, and Roxana de las Salas. 2019. “A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design”. Revista Colombiana De Ciencias Químico-Farmacéuticas 48 (3). https://doi.org/10.15446/rcciquifa.v48n3.84982.

Harvard

Burgos-Flórez, F. J. and de las Salas, R. (2019) “A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design”, Revista Colombiana de Ciencias Químico-Farmacéuticas, 48(3). doi: 10.15446/rcciquifa.v48n3.84982.

IEEE

[1]
F. J. Burgos-Flórez and R. de las Salas, “A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design”, Rev. Colomb. Cienc. Quím. Farm., vol. 48, no. 3, Sep. 2019.

MLA

Burgos-Flórez, F. J., and R. de las Salas. “A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design”. Revista Colombiana de Ciencias Químico-Farmacéuticas, vol. 48, no. 3, Sept. 2019, doi:10.15446/rcciquifa.v48n3.84982.

Turabian

Burgos-Flórez, Francisco Javier, and Roxana de las Salas. “A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design”. Revista Colombiana de Ciencias Químico-Farmacéuticas 48, no. 3 (September 1, 2019). Accessed March 8, 2025. https://revistas.unal.edu.co/index.php/rccquifa/article/view/84982.

Vancouver

1.
Burgos-Flórez FJ, de las Salas R. A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 2019 Sep. 1 [cited 2025 Mar. 8];48(3). Available from: https://revistas.unal.edu.co/index.php/rccquifa/article/view/84982

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