Actividad Antitumoral y toxicidad de (+)-Curcufenol y de Curcudiol Aislados de la Esponja Marina Didisus oxeata

Antitumor activity and toxicity of Curcuphenol and Curcudiol isolated from marine sponge

El extracto metanólico, el extracto clorofórmico, el curcufenol y el curcudiol obtenido de la esponja fueron evaluados frente a Artemia salina obteniéndose una concentración letal media de 0.54, 5.57, 3.10 y 0.70 m g/mL, respectivamente. También se probó su actividad antitumoral mediante el bioensayo de tumorogénesis inducida por Agrobacterium tumefaciens en disco de zanahoria, produciéndose inhibición en concentraciones mayores de 60 m g/mL.

Two pure compounds were isolated by column chromatography from the chloroformic and methanolic extracts of the marine sponge Didicus oxeata and were identified by spectroscopic methods as the sesquiterpenes (+)-Curcuphenol and Curcudiol. The methanolic, chloroformic extracts, (+)-Curcuphenol and Curcudiol showed LC₅₀ of 0.54, 5.57, 3.10 and 0.70 m g/mL in Artemia salina larvae respectively. The same extracts and isolated compounds presented antitumour activity in concentrations major than 60 m g/mL by the method of Agrobacterium tumefacins in carrot disc.