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A descrição teórica da detecção eletroanalítica do letrozol, assistida pelo compósito VO(OH)-polipirrol, obtido catodicamente
Theoretical description for the letrozol electroanalytical determination, assisted by the cathodically obtained composite VO(OH)-polypyrrole
DOI:
https://doi.org/10.15446/rcciquifa.v48n3.84985Palavras-chave:
letrozol, elétrodos quimicamente modificados, polipirrol, oxihidróxido de vanádio, estado estacionário estável (pt)letrozol, chemically modified electrodes, polypyrrole, vanadium oxyhydroxide, stable steady-state (en)
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O processo da determinação eletroanalítica do fármaco letrozol, assistida pelo compósito VO(OH)-polipirrol, obtido mediante um processo catódico, foi descrito teoricamente. Tanto para a síntese do compósito, como para o processo eletroanalítico foi sugerido e analisado, mediante a teoria de estabilidade linear e análise de bifurcações, um modelo matemático. Foi mostrado que, ao contrário da eletrossíntese de polipirrol catódica, iniciada por um composto na solução, o polipirrol resultante tem uma morfologia mais “centrada” aos centros ativos da matriz, dopados pelos cátions VO2+. No entretanto, tanto a síntese do compósito, como o seu desempenho eletroanalítico com o letrozol podem ser considerados eficientes.
The process of the electroanalytical determination of letrozol drug, assisted by the cathodically obtained VO(OH)-Polypyrrole, has been theoretically described. For both the composite synthesis and electroanalytical function a mathematical model has been suggested and analyzed by means of linear stability theory and bifurcation analysis. It was shown that, contrarily to the cathodic polypyrrole electrosynthesis, initiated by a compound in a solution, the resulting cathodic polypyrrole has more “centred” morphology, in the relation to the matrix active centers, doped by VO2+ cations. Nevertheless, either the synthesis of the composite, or its electroanalytical function with letrozole may be considered efficient.
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