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Evaluation of dermal and ocular safety of natural products based on Murraya paniculata, Eucalyptus sp. and Indigofera suffruticosa Mill. in New Zealand rabbits
Evaluación de la seguridad dérmica y oftálmica de productos naturales a base de Murraya paniculata, Eucalyptus sp. e Indigofera suffruticosa Mill. en conejos Nueva Zelanda
DOI:
https://doi.org/10.15446/rfmvz.v71n2.111493Keywords:
acute dermal irritability, Murraya paniculata, Eucalyptus sp., Indigofera suffruticosa Mill (en)irritabilidad aguda dérmica, irritabilidad aguda oftálmica, Murraya paniculata, Eucalyptus sp., Indigofera suffruticosa Mill. (es)
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This study was conducted to evaluate the acute dermal and ocular irritant potential of three natural products obtained from medicinal plants Murraya paniculata (PNI), Eucalyptus sp. (PNII), and Indigofera suffruticosa Mill. (PNIII) for topical use in veterinary medicine. For the assessment of acute dermal and ocular irritability, methodologies from the Organization for Economic Cooperation and Development (OECD) were employed through guidelines 404 and 405, respectively, using New Zealand albino rabbits. The evaluated products showed no signs or symptoms of irritation/corrosion on the skin and eyes, exhibiting dermal and ocular irritation indices within the range of classification of non-irritating substances, according to the OECD Harmonized Integrated Classification System.
El presente trabajo se llevó a cabo para evaluar el potencial irritante agudo dérmico y ocular de tres productos naturales obtenidos de las plantas medicinales Murraya paniculata (PNI), Eucalyptus sp. (PNII) e Indigofera suffruticosa Mill. (PNIII) para su uso en la medicina veterinaria por vía tópica. Para la evaluación de la irritabilidad aguda dérmica y oftálmica, se aplicaron las metodologías de la Organización para la Cooperación y el Desarrollo Económico (OCDE) a través de las guías 404 y 405, respectivamente, empleando conejos albinos Nueva Zelanda. Los productos evaluados no evidenciaron signos ni síntomas de irritación/corrosión en la piel y los ojos, mostrando índices de irritación dérmica y ocular dentro del rango de clasificación de sustancias no irritantes, según el Sistema de Clasificación Integrado Armonizado de la OCDE.
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Copyright (c) 2024 E. Rodríguez-Leblanch, Y. Gonzáles-Pérez, Y. Duverger-González, Y. Mora-Tassé, O. Fong-Lores, P.A. Suárez-Arias, L. Pérez-Paredes, H. Salas-Martínez
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