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Dosymmetric estimates of 99mTc (MAA) and 133Xe in newborn lungs using Cristy-Eckerman / Segars representations
Estimaciones dosimétricas del 99mTc (MAA) y 133Xe en los pulmones de recién nacidos utilizando las representaciones de Cristy-Eckerman/Segars
DOI:
https://doi.org/10.15446/mo.n64.99290Keywords:
MIRD dosimetry, Cristy-Eckerman /segars representations, lungs (en)representaciones Cristy-Eckerman/Segars, pulmones, dosimetría MIRD (es)
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Using the Cristy-Eckerman (C-E) / Segars anatomical representations and the MIRD formalism, the Absorbed doses in lungs of newborn patients scanned with radiopharmaceuticals 133Xe (ventilation) and 99mTc (MAA) (perfusion) are estimated. These representations are phantoms used in Monte Carlo calculations to determine specific absorbed fractions, which, associated with the pharmaceutical residence time, determine the absorbed dose. Concerns about the dosimetric impact of using these ventilation / perfusion agents, as well as the use of different phantoms, were explored in newborn patients. When the lungs were scanned with 99mTc (MAA), the relative difference in total dose between the C-E / Segars anatomical representations was 1.0%. When the lungs were scanned with 133Xe, the relative difference in total dose between the anthropomorphic representations of C-E / Segars was 0.5%. Regardless of the radiopharmaceutical used for the pulmonary studies of a newborn patient, the substitution of the C-E representation for that of Segars does not reflect very significant changes in the calculation of the absorbed dose in the lungs, where the greatest dosimetric contribution is its self-dose, which is supplied mainly by the electrons produced during the 99mTc and 133Xe decay.
Usando las representaciones anatómicas de Cristy-Eckerman (C-E) / Segars y el formalismo MIRD, se estiman las dosis absorbidas en pulmones de pacientes recién nacidos explorados con radiofarmacos 133Xe (Ventilación) y 99mTc (MAA) (perfusión). Estas representaciones son fantomas utilizados en los cálculos de Monte Carlo en la determinación de fracciones absorbidas específicas, que asociadas al tiempo de residencia farmacéutica determinan la dosis absorbida. Preocupaciones sobre el impacto dosimétrico de usar estos agentes ventilación /perfusión, así como el uso de diferentes fantomas, se exploraron en pacientes recién nacidos. Cuando a los pulmones se exploran con 99mTc(MAA), la diferencia relativa en la dosis total entre las representaciones anatómicas de C-E / Segars fue de 1,0 %. Cuando a los pulmones se exploran con 133Xe, la diferencia relativa en la dosis total entre las representaciones antropomórficas de C-E / Segars fue de 0,5 %. Independientemente del radiofármaco utilizado para los estudios pulmonares de un paciente recién nacido, la sustitución de la representación de C-E por la de Segars no refleja cambios significativos en el cálculo de la dosis absorbida en los pulmones, donde la mayor contribución dosimétrica es su autodosis que es suministrada principalmente por los electrones producidos a lo largo de la desintegración del 99mTc y 133Xe.
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1. Marcial V. Vasquez, Héctor R. Vega, Santos L. Acuña, Huber E. Rodriguez, Marcela A. Vasquez, Hipólito F. Flores, Santos M. Tantaquispe. (2024). RADIOPHARMACEUTICAL RENAL DOSIMETRY USING SNYDER / CRISTY-ECKERMAN / SEGARS ANTHROPOMORPHIC REPRESENTATIONS. MOMENTO, (68), p.1. https://doi.org/10.15446/mo.n68.102552.
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