Publicado

2022-02-04

Coumarin (2H-1-Benzopyran-2-one) act against planktonic and biofilm forms of Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa

La cumarina (2H-1-Benzopiran-2-ona) actúa contra las formas planctónicas y de biopelícula de Staphylococcus aureus, Klebsiella pneumoniae y Pseudomonas aeruginosa

A cumarina (2H-1-benzopiran-2-ona) age contra as formas planctônicas e de biofilme de Staphylococcus aureus, Klebsiella pneumoniae e Pseudomonas aeruginosa

Palabras clave:

Coumarin, antibacterial activity, biofilms, 2H-1-Benzopyran-2-one (en)
Cumarina, actividad antibacterial, biopelículas, 2H-1-Benzopiran-2-ona (es)
Cumarina, atividade antibacteriana, biofilmes, 2H-1-benzopirano-2-ona (pt)

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Autores/as

  • Laísa Vilar Cordeiro Department of Pharmaceutical Science, Health Sciences Center, Federal University of Paraíba, 58033-455, João Pessoa
  • Helivaldo Diógenes da Silva Souza Biochemistry Department, Biosciences Center, Federal University of Rio Grande do Norte, Natal
  • Giulian César da Silva Sá Chemistry Department, Exact and Natural Sciences Center, Federal University of Paraíba, João Pessoa
  • Aleson Pereira Sousa Department of Pharmaceutical Science, Health Sciences Center, Federal University of Paraíba, 58033-455, João Pessoa
  • Thiago Ramalho de Figueiredo Department of Pharmaceutical Science, Health Sciences Center, Federal University of Paraíba, 58033-455, João Pessoa
  • Maria das Neves Silva Neta Department of Pharmaceutical Science, Health Sciences Center, Federal University of Paraíba, 58033-455, João Pessoa
  • José Maria Barbosa Filho Department of Pharmaceutical Science, Health Sciences Center, Federal University of Paraíba, 58033-455, João Pessoa
  • Edeltrudes de Oliveira Lima Department of Pharmaceutical Science, Health Sciences Center, Federal University of Paraíba, 58033-455, João Pessoa

Introduction: biofilm-related infections caused by Staphylococcus aureus, Klebsi-ella pneumoniae and Pseudomonas aeruginosa are difficult to treat and few effective pharmacological options are currently available for this purpose. In this context, coumarin (2H-1-Benzopyran-2-one) has been reported to have antibacterial and antibiofilm activity, but this potential remains poorly understood. Aim: to investi-gate the action of coumarin on planktonic and biofilm forms of S. aureus, K. pneu-moniae and P. aeruginosa. Results: a minimum inhibitory concentration (MIC) of coumarin ranging from 256 to 1024 μg/mL was observed, with a remarkable ability to inhibit the formation of biofilms and to act on mature biofilms in concentrations close to MIC. Conclusion: coumarin has strong activity against planktonic and biofilm forms on the three species of great relevance in the clinical scenario. These results are interesting to enable a pharmacological alternative for the treatment of these infections.

Introducción: las infecciones relacionadas con la biopelícula causadas por Staphylo-coccus aureus, Klebsiella pneumoniae y Pseudomonas aeruginosa son difíciles de tratar y actualmente existen pocas opciones farmacológicas eficaces para este propósito. En este contexto, se ha informado que la cumarina (2H-1-Benzopiran-2-ona) tiene actividad antibacteriana y antibiofilm, pero este potencial sigue siendo poco cono-cido. Objetivo: investigar la acción de la cumarina sobre formas planctónicas y de biopelículas de S. aureus, K. pneumoniae y P. aeruginosa. Resultados: se observó una concentración inhibitoria mínima (CMI) de cumarina en el rango de 256 a 1024 μg/mL, con una notable capacidad para inhibir la formación de biofilms y actuar sobre biofilms maduros en concentraciones cercanas a la CMI. Conclusión: la cumarina tiene una fuerte actividad contra las formas planctónicas y biofilm sobre las tres espe-cies de gran relevancia en el escenario clínico. Estos resultados son interesantes para habilitar una alternativa farmacológica para el tratamiento de estas infecciones.

IIntrodução: as infecções relacionadas ao biofilme causadas por Staphylococcus aureus, Klebsiella pneumoniae e Pseudomonas aeruginosa são difíceis de tratar e poucas opções farmacológicas eficazes estão disponíveis atualmente para esse propó-sito. Nesse contexto, foi relatado que a cumarina (2H-1-benzopirano-2-ona) tem atividade antibacteriana e antibiofilme, mas esse potencial permanece pouco conhe-cido. Objetivo: investigar a ação da cumarina sobre as formas planctônicas e de biofilme de S. aureus, K. pneumoniae e P. aeruginosa. Resultados: observou-se uma concentração inibitória mínima (CIM) de cumarina variando de 256 a 1024 μg/mL, com notável capacidade de inibir a formação de biofilmes e de atuar sobre biofilmes maduros em concentrações próximas à CIM. Conclusão: a cumarina possui forte atividade contra as formas planctônicas e de biofilme sobre as três espécies de grande relevância no cenário clínico. Esses resultados são interessantes para possibilitar uma alternativa farmacológica para o tratamento dessas infecções.

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