Publicado

2022-02-04

Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures

Método extendido de Hildebrand y modelo de Yalkowsky- Roseman en la estimación de la solubilidad de sulfadiazina y sulfametazina en algunas mezclas {etilenglicol (1) + agua (2)} a varias temperaturas

Método de Hildebrand estendido e modelo de Yalkowsky-Roseman na estimativa da solubilidade de sulfadiazina e sulfametazina em algumas misturas {etileno glicol (1) + água (2)} em várias temperaturas

DOI:

https://doi.org/10.15446/rcciquifa.v50n3.100240

Palabras clave:

Sulfadiazine, sulfamethazine, extended Hildebrand model, Yalkowsky- Roseman, solubility, cosolvent mixtures (en)
Sulfadiazina, sulfametazina, método estendido de Hildebrand, ecuación de Yalkowsky-Roseman., Solubilidade, misturas de cossolventes (pt)
Sulfadiazina, sulfametazina, método extendido de Hildebrand, Yalkowsky-Roseman, solubilidad, mezclas cosolventes (es)

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Autores/as

  • Martha Sofía Vargas-Santana Environmental Management and Engineering
  • Ana María Cruz-González Sifati Group Ingeniería S.A.S., Grupo de Investigaciones Ciencia, Ingeniería e Innovación, Palermo, Huila
  • Nestor Enrique Cerquera Universidad Surcolombiana, Faculty of Engineering, Agricultural Engineering Program, Hydro Engineering and Agricultural Development Research Group (GHIDA), Avenida Pastrana Borrero-Carrera 1, Neiva, Huila
  • Alana Sofia Escobar Rodriguez Sifati Group Ingeniería S.A.S., Grupo de Investigaciones Ciencia, Ingeniería e Innovación, Palermo, Huila
  • Rossember E. Cardenas Grupo de Fisicoquímica y Análisis Matemático, Facultad de Ciencias y Humanidades, Fundación Universidad de América, Avenida Circunvalar N.° 20-53, Bogotá D.C.
  • Omar Calderón-Losada Grupo de Fisicoquímica y Análisis Matemático, Facultad de Ciencias y Humanidades, Fundación Universidad de América, Avenida Circunvalar N.° 20-53
  • Claudia Patricia Ortiz Corporación Universitaria Minuto de Dios-UNIMINUTO, Programa de Administración en Salud Ocupacional, Grupo de Investigación en Seguridad y Salud en el Trabajo, Neiva, Huila
  • Daniel Ricardo Delgado Universidad Cooperativa de Colombia, Department of Engineering, Grupo de Investigación de Ingenierías UCC-Neiva, Calle 11 N.° 1-51, Neiva, Huila

Aim: extended Hildebrand Solubility Approach (EHSA) and Yalkowsky Roseman (YR) were applied to evaluate the solubility of sulfadiazine, and sulfamethazine in ethylene glycol + water mixtures. Methodology: reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations.Results: a good predictive character of EHSA (with mean deviations lower than 3.0%) were found by using regular polynomials in order two correlating the inter-action parameter W with the Hildebrand solubility parameter of solvent mixtures without drug ; however, the results obtained from YR model show relatively high deviations greater than 50%.

Objetivo: aplicar los enfoques de los modelos de Solubilidad Extendido de Hilde-brand (EHSA) y Yalkowsky Roseman (YR) para evaluar la solubilidad de sulfa-diazina y sulfametazina en mezclas de etilenglicol + agua. Metodología: para los cálculos se utilizaron las solubilidades experimentales en equilibrio reportadas y algunas propiedades de fusión de estos fármacos. Resultados: en particular, se encontró un buen carácter predictivo de EHSA (con desviaciones medias inferiores al 3,0%) utilizando polinomios regulares en orden dos correlacionando el parámetro de interacción W con el parámetro de solubilidad de Hildebrand de mezclas de disolventes sin fármaco; sin embargo, los resultados obtenidos del modelo YR mues-tran desviaciones relativamente altas superiores al 50%

Objetivo: aplicar as abordagens dos modelos de Solubilidade Estendida de Hilde-brand (EHSA) e Yalkowsky Roseman (YR) para avaliar a solubilidade de sulfadia-zina e sulfametazina em misturas de etilenoglicol + água. Metodologia: as solubi-lidades de equilíbrio experimental relatadas e algumas propriedades de fusão dessas drogas foram usadas para os cálculos. Resultados: em particular, foi encontrado um bom caráter preditivo de EHSA (com desvios médios menores que 3,0%) usando polinômios regulares na ordem dois, correlacionando o parâmetro de interação W com o parâmetro de solubilidade de Hildebrand de misturas de solventes sem fármaco; no entanto, os resultados obtidos com o modelo YR mostram desvios rela-tivamente altos superiores a 50%

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Cómo citar

APA

Vargas-Santana, M. S., Cruz-González, A. M., Cerquera, N. E. ., Escobar Rodriguez, A. S., Cardenas, R. E. ., Calderón-Losada, O. ., Ortiz, C. P. . & Delgado, D. R. (2022). Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures. Revista Colombiana de Ciencias Químico-Farmacéuticas, 50(3). https://doi.org/10.15446/rcciquifa.v50n3.100240

ACM

[1]
Vargas-Santana, M.S., Cruz-González, A.M., Cerquera, N.E. , Escobar Rodriguez, A.S., Cardenas, R.E. , Calderón-Losada, O. , Ortiz, C.P. y Delgado, D.R. 2022. Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures. Revista Colombiana de Ciencias Químico-Farmacéuticas. 50, 3 (feb. 2022). DOI:https://doi.org/10.15446/rcciquifa.v50n3.100240.

ACS

(1)
Vargas-Santana, M. S.; Cruz-González, A. M.; Cerquera, N. E. .; Escobar Rodriguez, A. S.; Cardenas, R. E. .; Calderón-Losada, O. .; Ortiz, C. P. .; Delgado, D. R. Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures. Rev. Colomb. Cienc. Quím. Farm. 2022, 50.

ABNT

VARGAS-SANTANA, M. S.; CRUZ-GONZÁLEZ, A. M.; CERQUERA, N. E. .; ESCOBAR RODRIGUEZ, A. S.; CARDENAS, R. E. .; CALDERÓN-LOSADA, O. .; ORTIZ, C. P. .; DELGADO, D. R. Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 50, n. 3, 2022. DOI: 10.15446/rcciquifa.v50n3.100240. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/100240. Acesso em: 27 dic. 2025.

Chicago

Vargas-Santana, Martha Sofía, Ana María Cruz-González, Nestor Enrique Cerquera, Alana Sofia Escobar Rodriguez, Rossember E. Cardenas, Omar Calderón-Losada, Claudia Patricia Ortiz, y Daniel Ricardo Delgado. 2022. «Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures». Revista Colombiana De Ciencias Químico-Farmacéuticas 50 (3). https://doi.org/10.15446/rcciquifa.v50n3.100240.

Harvard

Vargas-Santana, M. S., Cruz-González, A. M., Cerquera, N. E. ., Escobar Rodriguez, A. S., Cardenas, R. E. ., Calderón-Losada, O. ., Ortiz, C. P. . y Delgado, D. R. (2022) «Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures», Revista Colombiana de Ciencias Químico-Farmacéuticas, 50(3). doi: 10.15446/rcciquifa.v50n3.100240.

IEEE

[1]
M. S. Vargas-Santana, «Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures», Rev. Colomb. Cienc. Quím. Farm., vol. 50, n.º 3, feb. 2022.

MLA

Vargas-Santana, M. S., A. M. Cruz-González, N. E. . Cerquera, A. S. Escobar Rodriguez, R. E. . Cardenas, O. . Calderón-Losada, C. P. . Ortiz, y D. R. Delgado. «Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures». Revista Colombiana de Ciencias Químico-Farmacéuticas, vol. 50, n.º 3, febrero de 2022, doi:10.15446/rcciquifa.v50n3.100240.

Turabian

Vargas-Santana, Martha Sofía, Ana María Cruz-González, Nestor Enrique Cerquera, Alana Sofia Escobar Rodriguez, Rossember E. Cardenas, Omar Calderón-Losada, Claudia Patricia Ortiz, y Daniel Ricardo Delgado. «Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures». Revista Colombiana de Ciencias Químico-Farmacéuticas 50, no. 3 (febrero 4, 2022). Accedido diciembre 27, 2025. https://revistas.unal.edu.co/index.php/rccquifa/article/view/100240.

Vancouver

1.
Vargas-Santana MS, Cruz-González AM, Cerquera NE, Escobar Rodriguez AS, Cardenas RE, Calderón-Losada O, Ortiz CP, Delgado DR. Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 4 de febrero de 2022 [citado 27 de diciembre de 2025];50(3). Disponible en: https://revistas.unal.edu.co/index.php/rccquifa/article/view/100240

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