Publicado

2023-03-23

Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina

Determinación de compuestos bioactivos fenólicos y evaluación de las actividades antioxidante y hemolítica en los extractos metanólicos de Tradescantia zebrina

Determinação de compostos fenólicos bioativos e avaliação das atividades antioxidante e hemolítica em extratos metanólicos de Tradescantia zebrina

DOI:

https://doi.org/10.15446/rcciquifa.v51n3.101403

Palabras clave:

Tradescantia zebrina, antioxidants, phenolic compounds, HPLC-DAD, biological activity (en)
Tradescantia zebrina, antioxidantes, compuestos fenólicos, HPLC-DAD, actividad biológica (es)
Tradescantia zebrina, antioxidantes, compostos fenólicos, HPLC-DAD, atividade biológica (pt)

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Autores/as

  • Vagner Cardoso da Silva Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia.
  • Bárbara Elizabeth Alves de Magalhães Institute of Chemistry, Federal University of Bahia (UFBA), 147 Barão de Jeremoabo Street, Ondina, 40170-115, Salvador, Bahia.
  • Tatiana Barbosa dos Santos Magalhães Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia.
  • Elisalva Teixeira Guimarães Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia.
  • Alessandra da Silva Guedes Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia.
  • Milleno Dantas Mota Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia.
  • Walter Nei Lopes dos Santos Institute of Chemistry, Federal University of Bahia (UFBA), 147 Barão de Jeremoabo Street, Ondina, 40170-115, Salvador, Bahia.
  • Bruno Antonio Veloso Cerqueira Universidade do Estado da Bahia (UNEB)
  • Aníbal de Freitas Santos Júnior Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia. https://orcid.org/0000-0002-3022-0771
Introduction: Tradescantia zebrina is a species used mainly in South America, with few reports about its chemical composition and bioactivity. Aim: To determine phenolic bioactive compounds, for the first time in the literature, and the antioxidant and hemolytic activities of extracts (dried and in natura) of this species. Methods: The extracts were obtained by maceration in methanol and the total phenolic and flavonoid contents were expressed in mg equivalent of gallic acid (EAG)/g and quercetin (EQ) of extract, respectively. The antioxidant potential was evaluated by DPPH• and ABTS•+ radical capture methods. The identification and quantification of phenolic bioactive compounds was performed by high performance liquid chromatography coupled to a diode detector (HPLC-DAD) and, the hemolytic activity assay was performed by diffusion in blood agar, using the disk antiobiogram technique. Results: The total phenolic and flavonoid contents in the extracts (in natura and dried) were 67.68 and 233.94 mg EAG/g and 29.70 and 10.99 mg EQ/g of concentrated extract, respectively. Phenolic acids (caffeic, ellagic, ferulic, ρ-coumaric and protocatechuic), flavonoids (chrysin and rutin) and a phenolic aldehyde (vanillin) were determined by high performance liquid chromatography-diodearray detector (HPLC-DAD). The antioxidant activities were confirmed by inhibition of DPPH• (44.08%) and ABTS•+ (46.99%) radicals for in natura samples, respectively. Conclusion: The tested methanolic extracts of Tradescantia zebrina did not present toxicities when tested for hemolytic activity after 72 hours. Therefore, Tradescantia zebrina is a potential source of bioactive substances
 
 

Introducción: Tradescantia zebrina es una especie utilizada principalmente en Suda-mérica, hay pocos reportes sobre su composición química y bioactividad. Objetivo: determinar compuestos bioactivos fenólicos, por primera vez en la literatura, y las actividades antioxidante y hemolítica de extractos (secos e in natura) de esta especie. Métodos: los extractos se obtuvieron por maceración en metanol y los contenidos de fenoles y flavonoides totales se expresaron en mg equivalentes de ácido gálico (EAG)/g y quercetina (EQ) de extracto, respectivamente. El potencial antioxidante fue evaluado por los métodos de captura de radicales DPPH• y ABTS•+. La identifica-ción y cuantificación de compuestos bioactivos fenólicos se realizó por cromatografía líquida de alta resolución acoplada a detector de diodo (HPLC-DAD) y el ensayo de actividad hemolítica se realizó por difusión en agar sangre, utilizando la técnica de antiobiograma de disco. Resultados: los contenidos de fenoles y flavonoides totales en los extractos (in natura y secos) fueron 67,68 y 233,94 mg EAG/g y 29,70 y 10,99 mg EQ/g de extracto concentrado, respectivamente. Los ácidos fenólicos (cafeico, elágico, ferúlico, ρ-cumárico y protocatequiico), los flavonoides (crisina y rutina) y un aldehído fenólico (vainillina) se determinaron mediante cromatografía líquida de alta resolución-detector de diodos (HPLC-DAD). Las actividades antioxidantes fueron confirmadas por la inhibición de los radicales DPPH• (44,08%) y ABTS•+(46,99%) para muestras in natura, respectivamente. Conclusión: los extractos metanólicos de Tradescantia zebrina probados no presentaron toxicidades cuando se probaron para la actividad hemolítica después de 72 horas. Por lo tanto, Tradescantia zebrina es una fuente potencial de sustancias bioactivas.

Introdução: Tradescantia zebrina é uma espécie utilizada principalmente na América do Sul, há poucos relatos sobre sua composição química e bioatividade. Objetivo: determinar compostos bioativos fenólicos, pela primeira vez na literatura, e as atividades antioxidante e hemolítica de extratos (secos e in natura) desta espécie.Métodos: os extratos foram obtidos por maceração em methanol e os teores de compostos fenólicos e flavonóides totais foram expressos em mg equivalente de ácido gálico (EAG)/g e quercetina (EQ) de extrato, respectivamente. O potencial antioxidante foi avaliado pelos métodos de captura do radical DPPH• e ABTS•+. A identificação e quantificação de compostos bioativos fenólicos foi realizada por cromatografia líquida de alta eficiência acoplada a detector de diodo, na região do ultravioleta e o ensaio de atividade hemolítica foi realizado por difusão em ágar sangue, pela técnica de antiobiograma em discos. Resultados: os teores de fenóis totais e flavonoides nos extratos (in natura e seco) foram 67,68 e 233,94 mg EAG/g e 29,70 e 10,99 mg EQ/g de extrato concentrado, respectivamente. Ácidos fenólicos (caféico, elágico, ferúlico, ρ-cumárico e protocatecúico), flavonoides (crisina e rutina) e um aldeído fenólico (vanilina) foram determinados por cromatografia líquida de alta eficiência-detector de diodo (CLAE-DAD). As atividades antioxidantes foram confirmadas pela inibição dos radicais DPPH• (44,08%) e ABTS•+ (46,99%) para amostras in natura, respectivamente. Conclusão: os extratos metanólicos de Tradescantia zebrina testados não apresentaram toxicidade quando testados para atividade hemolítica após 72 horas. Portanto, Tradescantia zebrina é uma fonte potencial de substâncias bioativas.

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Cómo citar

APA

da Silva, V. C., Magalhães, B. E. A. de, Magalhães, T. B. dos S., Guimarães, E. T., Guedes, A. da S., Mota, M. D., dos Santos, W. N. L., Cerqueira, B. A. V. . y Santos Júnior, A. de F. (2023). Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina. Revista Colombiana de Ciencias Químico-Farmacéuticas, 51(3). https://doi.org/10.15446/rcciquifa.v51n3.101403

ACM

[1]
da Silva, V.C., Magalhães, B.E.A. de, Magalhães, T.B. dos S., Guimarães, E.T., Guedes, A. da S., Mota, M.D., dos Santos, W.N.L., Cerqueira, B.A.V. y Santos Júnior, A. de F. 2023. Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina. Revista Colombiana de Ciencias Químico-Farmacéuticas. 51, 3 (mar. 2023). DOI:https://doi.org/10.15446/rcciquifa.v51n3.101403.

ACS

(1)
da Silva, V. C.; Magalhães, B. E. A. de; Magalhães, T. B. dos S.; Guimarães, E. T.; Guedes, A. da S.; Mota, M. D.; dos Santos, W. N. L.; Cerqueira, B. A. V. .; Santos Júnior, A. de F. Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina. Rev. Colomb. Cienc. Quím. Farm. 2023, 51.

ABNT

DA SILVA, V. C.; MAGALHÃES, B. E. A. de; MAGALHÃES, T. B. dos S.; GUIMARÃES, E. T.; GUEDES, A. da S.; MOTA, M. D.; DOS SANTOS, W. N. L.; CERQUEIRA, B. A. V. .; SANTOS JÚNIOR, A. de F. Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 51, n. 3, 2023. DOI: 10.15446/rcciquifa.v51n3.101403. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/101403. Acesso em: 26 jul. 2024.

Chicago

da Silva, Vagner Cardoso, Bárbara Elizabeth Alves de Magalhães, Tatiana Barbosa dos Santos Magalhães, Elisalva Teixeira Guimarães, Alessandra da Silva Guedes, Milleno Dantas Mota, Walter Nei Lopes dos Santos, Bruno Antonio Veloso Cerqueira, y Aníbal de Freitas Santos Júnior. 2023. «Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina». Revista Colombiana De Ciencias Químico-Farmacéuticas 51 (3). https://doi.org/10.15446/rcciquifa.v51n3.101403.

Harvard

da Silva, V. C., Magalhães, B. E. A. de, Magalhães, T. B. dos S., Guimarães, E. T., Guedes, A. da S., Mota, M. D., dos Santos, W. N. L., Cerqueira, B. A. V. . y Santos Júnior, A. de F. (2023) «Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina», Revista Colombiana de Ciencias Químico-Farmacéuticas, 51(3). doi: 10.15446/rcciquifa.v51n3.101403.

IEEE

[1]
V. C. da Silva, «Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina», Rev. Colomb. Cienc. Quím. Farm., vol. 51, n.º 3, mar. 2023.

MLA

da Silva, V. C., B. E. A. de Magalhães, T. B. dos S. Magalhães, E. T. Guimarães, A. da S. Guedes, M. D. Mota, W. N. L. dos Santos, B. A. V. . Cerqueira, y A. de F. Santos Júnior. «Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina». Revista Colombiana de Ciencias Químico-Farmacéuticas, vol. 51, n.º 3, marzo de 2023, doi:10.15446/rcciquifa.v51n3.101403.

Turabian

da Silva, Vagner Cardoso, Bárbara Elizabeth Alves de Magalhães, Tatiana Barbosa dos Santos Magalhães, Elisalva Teixeira Guimarães, Alessandra da Silva Guedes, Milleno Dantas Mota, Walter Nei Lopes dos Santos, Bruno Antonio Veloso Cerqueira, y Aníbal de Freitas Santos Júnior. «Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina». Revista Colombiana de Ciencias Químico-Farmacéuticas 51, no. 3 (marzo 23, 2023). Accedido julio 26, 2024. https://revistas.unal.edu.co/index.php/rccquifa/article/view/101403.

Vancouver

1.
da Silva VC, Magalhães BEA de, Magalhães TB dos S, Guimarães ET, Guedes A da S, Mota MD, dos Santos WNL, Cerqueira BAV, Santos Júnior A de F. Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 23 de marzo de 2023 [citado 26 de julio de 2024];51(3). Disponible en: https://revistas.unal.edu.co/index.php/rccquifa/article/view/101403

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