Publicado

2023-03-23

Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina

Determinación de compuestos bioactivos fenólicos y evaluación de las actividades antioxidante y hemolítica en los extractos metanólicos de Tradescantia zebrina

Determinação de compostos fenólicos bioativos e avaliação das atividades antioxidante e hemolítica em extratos metanólicos de Tradescantia zebrina

DOI:

https://doi.org/10.15446/rcciquifa.v51n3.101403

Palabras clave:

Tradescantia zebrina, antioxidants, phenolic compounds, HPLC-DAD, biological activity (en)
Tradescantia zebrina, antioxidantes, compuestos fenólicos, HPLC-DAD, actividad biológica (es)
Tradescantia zebrina, antioxidantes, compostos fenólicos, HPLC-DAD, atividade biológica (pt)

Descargas

Autores/as

  • Vagner Cardoso da Silva Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia.
  • Bárbara Elizabeth Alves de Magalhães Institute of Chemistry, Federal University of Bahia (UFBA), 147 Barão de Jeremoabo Street, Ondina, 40170-115, Salvador, Bahia.
  • Tatiana Barbosa dos Santos Magalhães Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia.
  • Elisalva Teixeira Guimarães Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia.
  • Alessandra da Silva Guedes Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia.
  • Milleno Dantas Mota Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia.
  • Walter Nei Lopes dos Santos Institute of Chemistry, Federal University of Bahia (UFBA), 147 Barão de Jeremoabo Street, Ondina, 40170-115, Salvador, Bahia.
  • Bruno Antonio Veloso Cerqueira Universidade do Estado da Bahia (UNEB)
  • Aníbal de Freitas Santos Júnior Department of Life Sciences (DCV), State University of Bahia (UNEB), Campus I, 2555 Silveira Martins Street, Cabula, 41150-000, Salvador, Bahia. https://orcid.org/0000-0002-3022-0771
Introduction: Tradescantia zebrina is a species used mainly in South America, with few reports about its chemical composition and bioactivity. Aim: To determine phenolic bioactive compounds, for the first time in the literature, and the antioxidant and hemolytic activities of extracts (dried and in natura) of this species. Methods: The extracts were obtained by maceration in methanol and the total phenolic and flavonoid contents were expressed in mg equivalent of gallic acid (EAG)/g and quercetin (EQ) of extract, respectively. The antioxidant potential was evaluated by DPPH• and ABTS•+ radical capture methods. The identification and quantification of phenolic bioactive compounds was performed by high performance liquid chromatography coupled to a diode detector (HPLC-DAD) and, the hemolytic activity assay was performed by diffusion in blood agar, using the disk antiobiogram technique. Results: The total phenolic and flavonoid contents in the extracts (in natura and dried) were 67.68 and 233.94 mg EAG/g and 29.70 and 10.99 mg EQ/g of concentrated extract, respectively. Phenolic acids (caffeic, ellagic, ferulic, ρ-coumaric and protocatechuic), flavonoids (chrysin and rutin) and a phenolic aldehyde (vanillin) were determined by high performance liquid chromatography-diodearray detector (HPLC-DAD). The antioxidant activities were confirmed by inhibition of DPPH• (44.08%) and ABTS•+ (46.99%) radicals for in natura samples, respectively. Conclusion: The tested methanolic extracts of Tradescantia zebrina did not present toxicities when tested for hemolytic activity after 72 hours. Therefore, Tradescantia zebrina is a potential source of bioactive substances
 
 

Introducción: Tradescantia zebrina es una especie utilizada principalmente en Suda-mérica, hay pocos reportes sobre su composición química y bioactividad. Objetivo: determinar compuestos bioactivos fenólicos, por primera vez en la literatura, y las actividades antioxidante y hemolítica de extractos (secos e in natura) de esta especie. Métodos: los extractos se obtuvieron por maceración en metanol y los contenidos de fenoles y flavonoides totales se expresaron en mg equivalentes de ácido gálico (EAG)/g y quercetina (EQ) de extracto, respectivamente. El potencial antioxidante fue evaluado por los métodos de captura de radicales DPPH• y ABTS•+. La identifica-ción y cuantificación de compuestos bioactivos fenólicos se realizó por cromatografía líquida de alta resolución acoplada a detector de diodo (HPLC-DAD) y el ensayo de actividad hemolítica se realizó por difusión en agar sangre, utilizando la técnica de antiobiograma de disco. Resultados: los contenidos de fenoles y flavonoides totales en los extractos (in natura y secos) fueron 67,68 y 233,94 mg EAG/g y 29,70 y 10,99 mg EQ/g de extracto concentrado, respectivamente. Los ácidos fenólicos (cafeico, elágico, ferúlico, ρ-cumárico y protocatequiico), los flavonoides (crisina y rutina) y un aldehído fenólico (vainillina) se determinaron mediante cromatografía líquida de alta resolución-detector de diodos (HPLC-DAD). Las actividades antioxidantes fueron confirmadas por la inhibición de los radicales DPPH• (44,08%) y ABTS•+(46,99%) para muestras in natura, respectivamente. Conclusión: los extractos metanólicos de Tradescantia zebrina probados no presentaron toxicidades cuando se probaron para la actividad hemolítica después de 72 horas. Por lo tanto, Tradescantia zebrina es una fuente potencial de sustancias bioactivas.

Introdução: Tradescantia zebrina é uma espécie utilizada principalmente na América do Sul, há poucos relatos sobre sua composição química e bioatividade. Objetivo: determinar compostos bioativos fenólicos, pela primeira vez na literatura, e as atividades antioxidante e hemolítica de extratos (secos e in natura) desta espécie.Métodos: os extratos foram obtidos por maceração em methanol e os teores de compostos fenólicos e flavonóides totais foram expressos em mg equivalente de ácido gálico (EAG)/g e quercetina (EQ) de extrato, respectivamente. O potencial antioxidante foi avaliado pelos métodos de captura do radical DPPH• e ABTS•+. A identificação e quantificação de compostos bioativos fenólicos foi realizada por cromatografia líquida de alta eficiência acoplada a detector de diodo, na região do ultravioleta e o ensaio de atividade hemolítica foi realizado por difusão em ágar sangue, pela técnica de antiobiograma em discos. Resultados: os teores de fenóis totais e flavonoides nos extratos (in natura e seco) foram 67,68 e 233,94 mg EAG/g e 29,70 e 10,99 mg EQ/g de extrato concentrado, respectivamente. Ácidos fenólicos (caféico, elágico, ferúlico, ρ-cumárico e protocatecúico), flavonoides (crisina e rutina) e um aldeído fenólico (vanilina) foram determinados por cromatografia líquida de alta eficiência-detector de diodo (CLAE-DAD). As atividades antioxidantes foram confirmadas pela inibição dos radicais DPPH• (44,08%) e ABTS•+ (46,99%) para amostras in natura, respectivamente. Conclusão: os extratos metanólicos de Tradescantia zebrina testados não apresentaram toxicidade quando testados para atividade hemolítica após 72 horas. Portanto, Tradescantia zebrina é uma fonte potencial de substâncias bioativas.

Referencias

J.B.L. Tan, W.J. Yap, S.W. Tan, Y.Y. Lim, S. M. Lee, Antioxidant content, antioxidant activity, and antibacterial activity of five plants from the Commelinaceae family, Antioxidants, 3, 758-769 (2014).

A.J. Alonso-Castro, M.L. Villarreal, L.A. Salazar-Olivo, M. Gomez-Sanchez, F. Dominguez, A. Garcia-Carranca, Mexican medicinal plants used for cancer treatment: pharmacological, phytochemical and ethnobotanical studies, J Ethnopharmacol., 133, 945-972 (2011).

O.R. Alara, N.H. Abdurahman, C.I Ukaegbu, Extraction of phenolic compounds: a review, Curr. Res. Food Sci., 4, 200-214 (2021).

S.V.S. da Silva, O.M. Barboza, J.T. Souza, É. N. Soares, C.C. dos Santos, L.V. Pacheco, I.P. Santos, T.B.S. Magalhães, M.B.P. Soares, E.T. Guimarães, C. S. Meira, S.L. Costa, V.D.A. da Silva, L.L.B. de Santana, A. de Freitas-Santos Júnior, Structural design, synthesis and antioxidant, antileishmania, anti-inflammatory and anticancer activities of a novel quercetin acetylated derivative, Molecules, 26, 6923 (2021).

D. Stagos, Antioxidant activity of polyphenolic plant extracts, Antioxidants (Basel), 9, 19 (2020).

C. Manach, A. Mazur, A. Scalbert, Polyphenols and prevention of cardiovascular diseases, Curr. Opin. Lipidol., 16, 77-84 (2005).

E. Niki, Assessment of antioxidant capacity in vitro and in vivo, Free Radic. Biol. Med., 49, 503-515 (2010).

A.R. Tapas, D.M. Sakarkar, R.B. Kakde, Flavonoids as nutraceuticals: a review, Trop. J. Pharm. Res., 7, 1089-1099 (2008).

N. Baghalpour, S.A. Ayatollahi, N. Naderi, T. Hosseinabadi, Y. Taheri, J. Mahroo- Bakhtiyari, Z.K. Shinwari, A.T. Khalil, J. Sharifi-Rad, Antinociceptive and antiinflammatory studies on Tradescantia zebrina, Pak. J. Bot., 53, 357-365 (2021).

Z. Olivo-Vidal, J. Ruiz-Ruiz, V.S. Mayday, C. Irecta-Nájera, D.L.H. Ochoa, X.M. Sánchez-Chino, Pharmacological potential of Tradescantia zebrina leaf extracts, J. Biomed. Eng. Res., 4, 31-37 (2020).

S.Y. Cheah, C.Y. Magdalene, C.Z. Eldwin-Lim, M.H. Wong, S. Amir, S. Daniel, Y.C. Liow, S. Ketnipha, K. Karenjit, G.A. Gabriel, J.H. Chin, In-vitro antioxidant and acetylcholinesterase inhibitory activities of Tradescantia zebrina, Res. J. Pharm. Biol. Chem. Sci., 8, 82-87 (2017).

H.F.S. Moura, F.S. Dias, L.B. Souza e Souza, B.E.A. Magalhães, C.A. Tannus, W.C. Carvalho, G.C. Brandão, W.N.L. dos Santos, M.G.A. Korn, D.C.M.B. Santos, M.V. Lopes, D.A. Santana, A.F. Santos Júnior, Evaluation of multielement/ proximate composition and bioactive phenolics contents of unconventional edible plants from Brazil using multivariate analysis techniques, Food Chem., 363, 129995 (2021).

H. Nybom, K. Weising, B. Rotter, DNA fingerprinting in botany: past, present, future, Investig. Genet., 5, 1 (2014).

R.R. Sá, R.A. Matos, V.C. Silva, J.C. Caldas, M.C.S. Sauthier, W.N.L. dos Santos, H.I.F. Magalhães, A.F. Santos Júnior, Determination of bioactive phenolics in herbal medicines containing Cynara scolymus, Maytenus ilicifolia Mart ex Reiss and Ptychopetalum uncinatum by HPLC-DAD, Microchem. J., 135, 10-15 (2017).

R.R. Sá, J.C. Caldas, D.A. Santana, M.V. Lopes, W.N.L. dos Santos, M.G.A. Korn, A.F. Santos Júnior, Multielementar/centesimal composition and determination of bioactive phenolics in dried fruits and capsules containing Goji berries (Lycium barbarum L.), Food Chem., 273, 15-23 (2019).

L. Yun, S. Yao, Y. Chang-Liang, G. De-An, Quality assessment of herbal medicines based on chemical fingerprints combined with chemometrics approach: a review, J. Pharm. Biomed. Anal., 185, 113215 (2020).

J. Felix-Silva, I.M. Tomaz, M.G. Silva, K.S.C.R. Santos, A.A. Silva-Júnior, M.C.R.D. Carvalho, L.A.L. Soares, M.F. Fernandes-Pedrosa, Botanical and chemical identification of plant species of popular use in Rio Grande do Norte, Brazil, Rev. Bras. Plantas Med., 14, 548-555 (2012).

C.S. Paula, V.C.D. Canteli, M.C.S. Verdam, M. Kalegari, R. Campos, B.C.K. Hirota, O.G.M. Miguel, M.D. Miguel, Antioxidant activity and preliminary toxicity of the extracts and fractions obtained from the leaves and stem bark of Dasyphyllum tomentosum (Spreng.) Cabrera, Rev. Bras. Plantas Med., 16, 189- 195 (2014).

M. Kalegari, M.D. Miguel, J.D.F.G. Dias, A.L.L. Lordello, C.P.D. Lima, C.M.S. Miyazaki, S.M. Zanin, M.C. Verdam, O.G. Miguel, Phytochemical constituents and preliminary toxicity evaluation of leaves from Rourea induta Planch. (Connaraceae), Braz. J. Pharm. Sci., 47, 635-642 (2011).

M. Bonoli, V. Verardo, E. Marconi, M.F. Caboni, Antioxidant phenols in barley (Hordeum vulgare L.) flour: comparative spectrophotometric study among extraction methods of free and bound phenolic compounds, J. Agric. Food Chem., 52, 5195-5200 (2004).

R.G. Woisky, A. Salatino, Analysis of propolis: some parameters and procedures for chemical quality control, J. Apic. Res., 37, 99-105 (1998).

W. Brand-Williams, M.E. Cuvelier, C. Berset, Use of a free radical method to evaluate antioxidant activity, LWT - Food Sci. Technol., 28, 25-30 (1995).

N. Nenadis, L.F. Wang, M. Tsimidou, H.Y. Zhang, Estimation of scavenging activity of phenolic compounds using the ABTS(*+) assay. J. Agric. Food Chem., 52, 4669-4674 (2004).

B.E.A. Magalhães, D.A. Santana, I.M.J. Silva, L.A.C. Minho, M.A. Gomes, J.R.G.S. Almeida, W.N.L. dos Santos, Determination of phenolic composition of oilseed whole flours by HPLC-DAD with evaluation using chemometric analyses, Microchem. J., 155, 104683 (2020).

Brazilian Health Surveillance Agency (ANVISA), Resolution of the Collegiate Board of Directors - RDC, No. 166 of July 24, 2017, Providing for the validation of analytical methods and other provisions, Ministry of Health of Brazil, URL: https://www.in.gov.br/materia/-/asset_publisher/Kujrw0TZC2Mb/ content/id/19194581/do1-2017-07-25-resolucao-rdc-n-166-de-24-de-julhode- 2017-19194412, acessado em janeiro de 2022.

Clinical and Laboratory Standards Institute (CLSI), Performance standards for antimicrobial disk susceptibility tests; approved standard—eighth edition, NCCLS document M2-A8 (2015), URL: https://clsi.org/media/1631/ m02a12_sample.pdf, accessed em janeiro de 2022.

P.M. Elbl, G.F. Melo-de-Pinna, N.L. Menezes, Morphology and anatomy of leaf miners in two species of Commelinaceae (Commelina diffusa Burm. f. and Floscopa glabrata (Kunth) Hassk), Acta Bot. Bras., 24, 283-328 (2010).

H.A. Carvalho, Use of Tradescantia to monitor the clastogenic effects of ionizing radiation, Rev. Radiol. Bras., 38, 459-462 (2005).

J.A. Marchese, G.M. Figueira, The use of pre and post-harvest technologies and good agricultural practices in the production of medicinal and aromatic plants, Rev. Bras. Plantas Med., 7, 86-96 (2005).

E. Ahmed, M. Arshad, M.Z. Khan, M.S. Amjad, H.M. Sadaf, I. Riaz, S. Sabir, N. Ahmad, Sabaoon, Secondary metabolites and their multidimensional prospective in plant life, J. Pharmacogn. Phytochem., 6, 205-214 (2017).

D. Esquenazi, M.D. Wigg, M.M. Miranda, H.M. Rodrigues, J.B. Tostes, S. Rozental, A.J. Da Silva, C.S. Alviano, Antimicrobial and antiviral activities of polyphenolics from Cocos nucifera Linn. (Palmae) husk fiber extract, Res. Microbiol., 153, 647-652 (2002).

R. Gutam, S.M. Jachak, Recent developments in anti-inflammatory natural products, Med. Res. Rev., 29, 767-820 (2009).

M. Negri, T.P. Salci, C.S. Shinobu-Mesquita, I.R.G. Capoci, T.I.E. Svidzinski, E.S. Kioshima, Early state research on antifungal natural products, Molecules, 19, 2925-2956 (2014).

O. Sagdic, I. Ozturk, G. Ozkan, H. Yetim, L. Ekici, M.T. Yilmaz, RP-HPLC– DAD analysis of phenolic compounds in pomace extracts from five grape cultivars: Evaluation of their antioxidant, antiradical and antifungal activities in orange and apple juices, Food Chem., 126, 1749-1758 (2011).

C.S.M. Alaba, C.L. Chichioco-Hernandez, 15-Lipoxygenase inhibition of Commelina benghalensis, Tradescantia fluminensis, Tradescantia zebrina, Asian Pac. J. Trop. Biomed., 4, 184-188 (2014).

S.K. To, Stability of plant pigments in Tradescantia zebrina and Ixora coccinea Linn as potential food colorant with antioxidant activity (2020), URL: https:// eprints.tarc.edu.my/14408/#:~:text=For%20Tradescantia%20Zebrina%20 showed%20the,0.91%20%25)%20at%20pH%207.&text=Tradescantia%20Zebrina% 20and%20Ixora%20Coccinea%20Linn%20extracts%20have%20lower%20 viability,used%20as%20a%20food%20colorant, acessado em janeiro de 2022.

T. Katsube, Y. Tsurunaga, M. Sugiyama, T. Furuno, Y. Yamasaki, Effect of airdrying temperature on antioxidant capacity and stability of polyphenolic compounds in mulberry (Morus alba L.) leaves, Food Chem., 113, 964-969 (2009).

M. Gomes, B. Magalhães, W. Santos, J.R. Almeida, Influence of seasonality on phytochemical composition, phenolic content and antioxidant activity of Neoglaziovia variegata (Bromeliaceae), Biointerface Res. Appl. Chem., 12, 2889-2904 (2021).

S. Kabtni, D. Sdouga, I. Bettaib Rebey, M. Save, N. Trifi-Farah, M.L. Fauconnier, S. Marghali, Influence of climate variation on phenolic composition and antioxidant capacity of Medicago minima populations, Sci. Rep., 10, 8293 (2020).

M.A. Guadarrama-Olivera, De los “Matalis”, “señoritas embarcadas” y otras Commelinas en Tabasco, Kulxulkab, 17, 79-86 (2010).

L. Gobbo-Neto, N.P. Lopes, Medicinal plants: factors of influence on the content of secondary metabolites, Quim. Nova, 30, 374-381 (2007).

T. Afsar, S. Razak, M.R. Khan, S. Mawash, A. Almajwal, M. Shabir, I.U. Haq, Evaluation of antioxidant, anti-hemolytic and anticancer activity of various solvent extracts of Acacia hydaspica R. Parker aerial parts, BMC Complement. Altern. Med., 16, 258 (2016).

T.D. Coates, Physiology and pathophysiology of iron in hemoglobin-associated diseases, Free Radic. Biol. Med., 72, 23-40 (2014).

E.B. Carvalho, E.L. Borges, L.M.B. Carlos, M.A.M. Silva, S.M.M. Magalhães, F.V.B.A.F. Gomes, M.J.C. Carvalho, A.T.S. Quixadá, Effect of the infusion pumps of solutions on the degree of hemolysis, Rev. Bras. Hematol. Hemoter., 29, 149-152 (2007).

Cómo citar

APA

da Silva, V. C., Magalhães, B. E. A. de, Magalhães, T. B. dos S., Guimarães, E. T., Guedes, A. da S., Mota, M. D., dos Santos, W. N. L., Cerqueira, B. A. V. . y Santos Júnior, A. de F. (2023). Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina. Revista Colombiana de Ciencias Químico-Farmacéuticas, 51(3). https://doi.org/10.15446/rcciquifa.v51n3.101403

ACM

[1]
da Silva, V.C., Magalhães, B.E.A. de, Magalhães, T.B. dos S., Guimarães, E.T., Guedes, A. da S., Mota, M.D., dos Santos, W.N.L., Cerqueira, B.A.V. y Santos Júnior, A. de F. 2023. Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina. Revista Colombiana de Ciencias Químico-Farmacéuticas. 51, 3 (mar. 2023). DOI:https://doi.org/10.15446/rcciquifa.v51n3.101403.

ACS

(1)
da Silva, V. C.; Magalhães, B. E. A. de; Magalhães, T. B. dos S.; Guimarães, E. T.; Guedes, A. da S.; Mota, M. D.; dos Santos, W. N. L.; Cerqueira, B. A. V. .; Santos Júnior, A. de F. Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina. Rev. Colomb. Cienc. Quím. Farm. 2023, 51.

ABNT

DA SILVA, V. C.; MAGALHÃES, B. E. A. de; MAGALHÃES, T. B. dos S.; GUIMARÃES, E. T.; GUEDES, A. da S.; MOTA, M. D.; DOS SANTOS, W. N. L.; CERQUEIRA, B. A. V. .; SANTOS JÚNIOR, A. de F. Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 51, n. 3, 2023. DOI: 10.15446/rcciquifa.v51n3.101403. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/101403. Acesso em: 15 mar. 2025.

Chicago

da Silva, Vagner Cardoso, Bárbara Elizabeth Alves de Magalhães, Tatiana Barbosa dos Santos Magalhães, Elisalva Teixeira Guimarães, Alessandra da Silva Guedes, Milleno Dantas Mota, Walter Nei Lopes dos Santos, Bruno Antonio Veloso Cerqueira, y Aníbal de Freitas Santos Júnior. 2023. «Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina». Revista Colombiana De Ciencias Químico-Farmacéuticas 51 (3). https://doi.org/10.15446/rcciquifa.v51n3.101403.

Harvard

da Silva, V. C., Magalhães, B. E. A. de, Magalhães, T. B. dos S., Guimarães, E. T., Guedes, A. da S., Mota, M. D., dos Santos, W. N. L., Cerqueira, B. A. V. . y Santos Júnior, A. de F. (2023) «Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina», Revista Colombiana de Ciencias Químico-Farmacéuticas, 51(3). doi: 10.15446/rcciquifa.v51n3.101403.

IEEE

[1]
V. C. da Silva, «Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina», Rev. Colomb. Cienc. Quím. Farm., vol. 51, n.º 3, mar. 2023.

MLA

da Silva, V. C., B. E. A. de Magalhães, T. B. dos S. Magalhães, E. T. Guimarães, A. da S. Guedes, M. D. Mota, W. N. L. dos Santos, B. A. V. . Cerqueira, y A. de F. Santos Júnior. «Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina». Revista Colombiana de Ciencias Químico-Farmacéuticas, vol. 51, n.º 3, marzo de 2023, doi:10.15446/rcciquifa.v51n3.101403.

Turabian

da Silva, Vagner Cardoso, Bárbara Elizabeth Alves de Magalhães, Tatiana Barbosa dos Santos Magalhães, Elisalva Teixeira Guimarães, Alessandra da Silva Guedes, Milleno Dantas Mota, Walter Nei Lopes dos Santos, Bruno Antonio Veloso Cerqueira, y Aníbal de Freitas Santos Júnior. «Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina». Revista Colombiana de Ciencias Químico-Farmacéuticas 51, no. 3 (marzo 23, 2023). Accedido marzo 15, 2025. https://revistas.unal.edu.co/index.php/rccquifa/article/view/101403.

Vancouver

1.
da Silva VC, Magalhães BEA de, Magalhães TB dos S, Guimarães ET, Guedes A da S, Mota MD, dos Santos WNL, Cerqueira BAV, Santos Júnior A de F. Determination of phenolic bioactive compounds and evaluation of the antioxidant and hemolytic activities in the methanolic extracts of Tradescantia zebrina. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 23 de marzo de 2023 [citado 15 de marzo de 2025];51(3). Disponible en: https://revistas.unal.edu.co/index.php/rccquifa/article/view/101403

Descargar cita

CrossRef Cited-by

CrossRef citations0

Dimensions

PlumX

Plum Print visual indicator of research metrics
  • Captures
  • Mendeley - Readers: 15
-
see details

Visitas a la página del resumen del artículo

951

Descargas

Licencia

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

El Departamento de Farmacia de la Facultad de Ciencias de la Universidad Nacional de Colombia  autoriza la fotocopia de artículos y textos para fines de uso académico o interno de las instituciones citando la fuente. Las ideas emitidas por los autores son responsabilidad expresa de estos y no de la revista.

Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons de Atribución 4.0 aprobada en Colombia. Consulte la normativa en: http://co.creativecommons.org/?page_id=13