Publicado
Modulation of IL-6 in ameliorating arthritic conditions in rats by Rosa alba L flower extract and fraction
Modulación de IL-6 en la mejora de afecciones artríticas en ratas por extracto y fracción de flor de Rosa alba L
Modulação de IL-6 na melhora de condições artríticas em ratos por extrato e fração de flor de Rosa alba L
DOI:
https://doi.org/10.15446/rcciquifa.v52n1.103423Palabras clave:
Complete freund’s adjuvant, histopathology, HPTLC, interleukin, quercetin (en)Adyuvante completo de Freund, histopatología, HPTLC, interleucina, quercetina (es)
Adjuvante completo de Freund, histopatologia, HPTLC, interleucina, quercetina (pt)
Descargas
Introduction: rheumatoid arthritis characterized by joint inflammation and pain,
affecting millions of peoples around the world. Traditional system of medicine had
proven to be preventive and treating physical and mental illness. Objective: the
objective of the study is to assess anti-arthritic potential of the plant Rosa alba L by
considering CFA, formaldehyde and turpentine oil induced arthritic model. Material
and Method: ethanolic extract and its ethyl acetate fraction were considered for the
study and quercetin was quantitatively estimated by high performance thin layer chromatographic
(HPTLC) method. Moreover, hematological and biochemical studies
(IL-6) were performed in blood and serum of wistar albino rat. Then histopathological
studies had also been performed on rat hind paw joint. Result: phytochemical
screening estimated the presence of carbohydrates, phenolic compounds, flavonoids,
phytosterols, amino acids and fixed oil in ethanolic extract and ethyl acetate fraction of
the plant. Amount of quercetin in the flowers of the plant was found to be 0.26% w/w
by quantitative HPTLC method. The level of proinflammatory cytokines, interleukin
(IL-6) was considerably decreased (p<0.001) in the fraction treated group of rats at
400 mg/kg b.w by considering complete freund’s adjuvant (CFA) induced arthritic model.
Conclusion: Ameliorated hematological,hematological, biochemical and histopathological
parameters confirmed the antiarthritic potential of the plant.
Introducción: artritis reumatoide caracterizada por inflamación y dolor articular,
que afecta a millones de personas en todo el mundo. El sistema tradicional de medicina
había demostrado ser preventivo y tratar enfermedades físicas y mentales. Objetivo:
el objetivo del estudio es evaluar el potencial antiartrítico de la planta Rosa
alba L considerando el modelo artrítico inducido por CFA, formaldehído y aceite de
trementina. Material y método: el extracto etanólico y su fracción de acetato de etilo
se consideraron para el estudio y la quercetina se estimó cuantitativamente mediante
el método cromatográfico en capa fina de alto rendimiento (HPTLC). Además, se
realizaron estudios hematológicos y bioquímicos (IL-6) en sangre y suero de rata
albina wistar. A continuación, también se realizaron estudios histopatológicos en
la articulación de la pata trasera de rata. Resultado: el cribado fitoquímico estimó
la presencia de carbohidratos, compuestos fenólicos, flavonoides, fitoesteroles,
aminoácidos y aceite fijo en el extracto etanólico y la fracción de acetato de etilo de
la planta. Se encontró que la cantidad de quercetina en las flores de la planta era del
0,26% p / p por el método de HPTLC cuantitativo. El nivel de citocinas proinflamatorias,
interleucina (IL-6), disminuyó considerablemente (p<0,001) en el grupo
de ratas tratado con fracción a 400 mg/kg de peso corporal considerando el modelo
artrítico inducido por adyuvante de Freund (CFA) completo. Conclusión: la mejora
de los parámetros hematológicos, bioquímicos e histopatológicos confirmó el potencial
antiartrítico de la planta.
Introdução: artrite reumatóide caracterizada por inflamação e dor nas articulações,
afetando milhões de pessoas em todo o mundo. O sistema tradicional de medicina
provou ser preventivo e tratamento de doenças físicas e mentais. Objetivo: avaliar o
potencial antiartrítico da planta Rosa alba L, considerando o modelo artrítico induzido
por CFA, formaldeído e óleo de terebintina. Material e Método: o extrato
etanólico e sua fração acetato de etila foram considerados para o estudo e a quercetina
foi estimada quantitativamente pelo método de cromatografia em camada
delgada de alta eficiência (HPTLC). Além disso, estudos hematológicos e bioquímicos
(IL-6) foram realizados em sangue e soro de ratos wistar albinos. Em seguida,
estudos histopatológicos também foram realizados na articulação da pata traseira
do rato. Resultado: a triagem fitoquímica estimou a presença de carboidratos,
compostos fenólicos, flavonoides, fitoesteróis, aminoácidos e óleo fixo no extrato
etanólico e na fração acetato de etila da planta. A quantidade de quercetina nas
flores da planta foi de 0,26% p/p pelo método quantitativo de HPTLC. O nível
de citocinas pró-inflamatórias, interleucina (IL-6) foi consideravelmente diminuído
(p<0,001) no grupo de ratos tratados com fração a 400 mg/kg b.w, considerando o
modelo artrítico induzido por adjuvante completo de Freund (CFA). Conclusão: a
melhora dos parâmetros hematológicos, bioquímicos e histopatológicos confirmou
o potencial antiartrítico da planta.
Referencias
Q. Guo, Y. Wang, D. Xu, J. Nossent, N.J. Pavlos, J. Xu, Rheumatoid arthritis:
pathological mechanisms and modern pharmacologic therapies, Bone Res., 6, 15
(2018).
S. Safiri, A.A. Kolahi, D. Hoy, E. Smith, D. Bettampadi, M.A. Mansournia, A.
Almasi-Hashiani, A. Ashrafi-Asgarabad, M. Moradi-Lakeh, M. Qorbani, G.
Collins, A.D. Woolf, L. March, M. Cross, Global, regional and national burden
of rheumatoid arthritis 1990-2017: a systematic analysis of the Global Burden of
Disease study 2017, Ann. Rheum. Dis., 78, 1463-1471 (2019). DOI: https://doi.org/10.1136/annrheumdis-2019-215920
S.A. Tabish, Complementary and Alternative Healthcare: Is it Evidence-based?,
Int. J. Health Sci. (Qassim), 2, 5-9 (2008).
A. Verma, R. Srivastava, P.K. Sonar, R. Yadav, Traditional, phytochemical, and
biological aspects of Rosa alba L.: A systematic review, Futur. J. Pharm. Sci., 6,
(2020).
A. Georgieva, A. Dobreva, E. Tzvetanova, A. Alexandrova, M. Mileva, Comparative
study of phytochemical profiles and antioxidant properties of hydrosols
from Bulgarian Rosa alba L. and Rosa damascena Mill, J. Essent. Oil-Bear. Plants,
, 1362-1371 (2019).
M.M. Mileva, V.K. Kusovski, D.S. Krastev, A.M. Dobreva, A.S. Galabov, Chemical
composition, in vitro antiradical and antimicrobial activities of Bulgarian
Rosa alba L. essential oil against some oral pathogens, Int. J. Curr. Microbiol. App.
Sci., 3(7) 11-20 (2014). DOI: https://doi.org/10.12659/MSM.889857
N. Sethi, D. Nath, R. Singh, R. Srivastava, Antifertility and teratogenic activity
of some indigenous medicinal plants in rats, Fitoterapia, 61(1), 64-67 (1990).
G. Jovtchev, A. Stankov, A. Georgieva, A. Dobreva, R. Bakalova, I. Aoki, M.
Mileva, Cytotoxic and genotoxic potential of Bulgarian Rosa alba L. essential
oil – in vitro model study, Biotechnol. Biotechnol. Equip., 32, 513-519 (2018). DOI: https://doi.org/10.1080/13102818.2017.1423245
G. Avneet, S.M. Pal, S.S. Siddhraj, A review on herbal Ayurvedic medicinal plants
and its association with memory functions, J. Phytopharmacol., 7, 162-166 (2018). DOI: https://doi.org/10.31254/phyto.2018.7210
M. Fukada, E. Kano, M. Miyoshi, R. Komaki, T. Watanabe, Effect of ‘rose essential
oil’ inhalation on stress-induced skin-barrier disruption in rats and humans,
Chem. Senses, 37, 347-356 (2012). DOI: https://doi.org/10.1093/chemse/bjr108
L. Breton, N. Pineau, Bradykinin antagonists comprising rosaceae plant extracts,
Patent No. US 6,586,020 B1, 2003. DOI: https://doi.org/10.1016/S1351-4180(03)00931-0
M.M. Mileva, E. Krumova, J. Miteva-Staleva, N. Kostadinova, A. Dobreva, A.S.
Galabov, Chemical compounds, in vitro antioxidant and antifungal activities of
some plant essential oils belonging to Rosaceae family, Comptes rendus de l’Acad
’emie bulgare des Sciences, 67(10), 1363-1368 (2014).
P. Brzezinski, L. Martini, Rosacea treated with rose petals: a calembour that
affords intriguing results, Our Dermatology Online, 10, 393-395 (2019). DOI: https://doi.org/10.7241/ourd.20194.23
K. Hosni, Rosa × alba: source of essential minerals and volatile oils, Nat. Products
Bioprospect., 1, 57–61, (2011). DOI: https://doi.org/10.3917/spi.057.0061
K.R. Kirtikar, B.D. Basu, Indian medicinal plants, 2nd ed., Edited, Revised,
enlarged, and mostly rewritten by E. Blatter, J.F. Caius, and K.S. Mhaskar, Lalit
Mohan Basu, Allahābād, India, 1935.
J.B. Harbone, Methods of Extraction and Isolation, in Phytochemical Methods,
Chapman and Hall, London, 1998, pp. 60-66.
OECD, Test no. 423: Acute oral toxicity - acute toxic class method, Organisation
for Economic Co-operation and Development, 2002.
T. Opriessnig, L.G. Giménez-Lirola, P.G. Halbur, Polymicrobial respiratory disease
in pigs, Anim. Health Res. Rev., 12, 133-148 (2011). DOI: https://doi.org/10.1017/S1466252311000120
A.D. Fischer, A. Adeyemo, M.E. O’Leary, A. Bottaro, Animal models of rheumatoid
pain: experimental systems and insights, Arthritis Res. Ther., 19(1), 146
(2017).
M. Murakami, T. Hirano, The molecular mechanisms of chronic inflammation
development, Front. Immunol., 3, 323 (2012).
S. Ekambaram, S.S. Perumal, V. Subramanian, Evaluation of antiarthritic activity
of Strychnos potatorum Linn seeds in Freund’s adjuvant induced arthritic rat
model, BMC Complement. Altern. Med., 10, 56 (2010). DOI: https://doi.org/10.1186/1472-6882-10-56
S. Ito, E. Okuda-Ashitaka, T. Minami, Central and peripheral roles of prostaglandins
in pain and their interactions with novel neuropeptides nociceptin and
nocistatin, Neurosci. Res., 41, 299-332 (2001). DOI: https://doi.org/10.1016/S0168-0102(01)00289-9
V. Pallinti, N. Ganesan, M. Anbazhagan, G. Rajasekhar, Serum biochemical
markers in rheumatoid arthritis, Indian J. Biochem. Biophys., 46, 342-344 (2009).
S.F. Libregts, L. Gutiérrez, A.M. de Bruin, F.M. Wensveen, P. Papadopoulos, W.
van Ijcken, Z. Ozgür, S. Philipsen, M.A. Nolte, Chronic IFN-γ production in
mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis
through an IRF-1/PU.1 axis, Blood, 118(9), 2578-2588 (2011). DOI: https://doi.org/10.1182/blood-2010-10-315218
W. Ansar, S. Ghosh, Biology of C reactive protein in health and disease, 1st ed.,
Springer, New Delhi, India, 2016.
M. Milovanovic, E. Nilsson, P. Järemo, Relationships between platelets and
inflammatory markers in rheumatoid arthritis, Clin. Chim. Acta, 343, 237-240
(2004).
K. Yuan, Q. Zhu, Q. Lu, H. Jiang, M. Zhu, X. Li, G. Huang, A. Xu, Quercetin
alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities,
J. Nutr. Biochem., 84, 108454 (2020). DOI: https://doi.org/10.1016/j.jnutbio.2020.108454
Cómo citar
APA
ACM
ACS
ABNT
Chicago
Harvard
IEEE
MLA
Turabian
Vancouver
Descargar cita
CrossRef Cited-by
1. Muhammad Usman Bari, Bilal Aslam, Faisal Muhammad Naeem, Asif Hussain, Wafa Majeed, Ibrahim A. Alhidary, Samia H. Abdelrahman, Simona Taricone. (2024). The protective effects of Acorus calamus L. rhizome extracts against rheumatoid arthritis-associated dyslipidemia, oxidative stress, and liver injury in rats . Journal of Applied Animal Research, 52(1) https://doi.org/10.1080/09712119.2024.2402045.
Dimensions
PlumX
Visitas a la página del resumen del artículo
Descargas
Licencia

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
El Departamento de Farmacia de la Facultad de Ciencias de la Universidad Nacional de Colombia autoriza la fotocopia de artículos y textos para fines de uso académico o interno de las instituciones citando la fuente. Las ideas emitidas por los autores son responsabilidad expresa de estos y no de la revista.
Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons de Atribución 4.0 aprobada en Colombia. Consulte la normativa en: http://co.creativecommons.org/?page_id=13