Published

2019-05-01

Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats

Efecto de la administración del aceite esencial de Lippia alba sobre la obesidad y los marcadores T2DM en ratas wistar

DOI:

https://doi.org/10.15446/rcciquifa.v48n2.82718

Keywords:

Cytokines, essential oil, Lippia alba, metabolism, obesity, type 2 diabetes mellitus (en)
Metabolismo, aceite esencial, Lippia alba, adipocitoquinas, obesidad, DMT2 (es)

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Authors

  • Maria Victoria Acevedo-Estupiñan Universidad Industrial de Santander - Medicine School - Basic Sciences Department - Research Group on Tropical Diseases -CINTROP
  • Elena Stashenko Universidad Industrial de Santander - Basic Science School - Chemistry Department - Research Center for Agro-industrialization of Tropical Medicinal Aromatic Plant Species (CENIVAM)
  • Fernando Rodríguez-Sanabria Universidad Industrial de Santander - Medicine School - Basic Sciences Research Department - Group on Tropical Diseases (CINTROP) and Research Group of Human Genetics
Introduction: Lippia alba (Mill) N.E. Brown (Verbenaceae) is an aromatic plant from Central America, South America, and the Caribbean, it is traditionally used by the Colombian population to treat various diseases such as diabetes and hypertension. The purpose of this research was to evaluate the metabolic effects of Lippia alba essential oil (EO) oral administration on obesity and diabetes markers in Wistar rats. Methods: control and Streptozotocin (STZ) diabetes induced rats were used to evaluate the EO metabolic effects. Glucose and triglycerides were measured using commercial colorimetric kits, the animals’ weight was followed for 21 days treatment and TNF- and adiponectin concentration was determined with ELISA technique. Results: The consumption of EO shows body weight gain regulation, lower glucose and cholesterol levels in normal rats and lower TNF- in comparison with the Glibenclamide treated rats between the STZ diabetic groups. No toxic effects were founded. Conclusions: The EO exerts a benefical metabolic effect in rats, therefore it is interesting to be evaluate a future in human beings with T2DM or overweight.
Introducción: Lippia alba (Mill) N.E. Brown (Verbenaceae) más conocida como pronto alivio, es una planta aromática de Centro, Sur América y el Caribe que se utiliza tradicionalmente en Colombia para el tratamiento de diversas enfermedades, como la diabetes e hipertensión. El objetivo del trabajo fue evaluar el efecto metabólico del aceite esencial de Lippia alba (Mill), administrado oralmente, sobre moléculas relacionadas con obesidad y diabetes en ratas Wistar. Métodos: se pesaron los animales diariamente. Después de 21 días de tratamiento con el AE se determinó en plasma la glucosa, triglicéridos con kits comerciales y las adipocitoquinas (adiponectina y factor de necrosis tumoral alfa (TNF) marcadores de resistencia a la acción de la insulina) por la técnica de ELISA. Resultados: el consumo de AE mostró una regulación en la ganancia de peso corporal y disminución en los niveles de glucosa y triglicéridos en los animales normales que recibieron el AE. Dentro de los grupos con diabetes inducida, el grupo tratado con AE mostró menores valores de TNF- comparado con el grupo tratado con glibenclamida. Conclusiones: el AE ejerce un efecto benéfico en el metabolismo de los animales, por lo tanto, es interesante para ser evaluado en seres humanos con diabetes o sobrepeso.

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How to Cite

APA

Acevedo-Estupiñan, M. V., Stashenko, E. and Rodríguez-Sanabria, F. (2019). Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats. Revista Colombiana de Ciencias Químico-Farmacéuticas, 48(2), 411–424. https://doi.org/10.15446/rcciquifa.v48n2.82718

ACM

[1]
Acevedo-Estupiñan, M.V., Stashenko, E. and Rodríguez-Sanabria, F. 2019. Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats. Revista Colombiana de Ciencias Químico-Farmacéuticas. 48, 2 (May 2019), 411–424. DOI:https://doi.org/10.15446/rcciquifa.v48n2.82718.

ACS

(1)
Acevedo-Estupiñan, M. V.; Stashenko, E.; Rodríguez-Sanabria, F. Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats. Rev. Colomb. Cienc. Quím. Farm. 2019, 48, 411-424.

ABNT

ACEVEDO-ESTUPIÑAN, M. V.; STASHENKO, E.; RODRÍGUEZ-SANABRIA, F. Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 48, n. 2, p. 411–424, 2019. DOI: 10.15446/rcciquifa.v48n2.82718. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/82718. Acesso em: 22 jan. 2025.

Chicago

Acevedo-Estupiñan, Maria Victoria, Elena Stashenko, and Fernando Rodríguez-Sanabria. 2019. “Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats”. Revista Colombiana De Ciencias Químico-Farmacéuticas 48 (2):411-24. https://doi.org/10.15446/rcciquifa.v48n2.82718.

Harvard

Acevedo-Estupiñan, M. V., Stashenko, E. and Rodríguez-Sanabria, F. (2019) “Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats”, Revista Colombiana de Ciencias Químico-Farmacéuticas, 48(2), pp. 411–424. doi: 10.15446/rcciquifa.v48n2.82718.

IEEE

[1]
M. V. Acevedo-Estupiñan, E. Stashenko, and F. Rodríguez-Sanabria, “Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats”, Rev. Colomb. Cienc. Quím. Farm., vol. 48, no. 2, pp. 411–424, May 2019.

MLA

Acevedo-Estupiñan, M. V., E. Stashenko, and F. Rodríguez-Sanabria. “Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats”. Revista Colombiana de Ciencias Químico-Farmacéuticas, vol. 48, no. 2, May 2019, pp. 411-24, doi:10.15446/rcciquifa.v48n2.82718.

Turabian

Acevedo-Estupiñan, Maria Victoria, Elena Stashenko, and Fernando Rodríguez-Sanabria. “Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats”. Revista Colombiana de Ciencias Químico-Farmacéuticas 48, no. 2 (May 1, 2019): 411–424. Accessed January 22, 2025. https://revistas.unal.edu.co/index.php/rccquifa/article/view/82718.

Vancouver

1.
Acevedo-Estupiñan MV, Stashenko E, Rodríguez-Sanabria F. Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 2019 May 1 [cited 2025 Jan. 22];48(2):411-24. Available from: https://revistas.unal.edu.co/index.php/rccquifa/article/view/82718

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1. P. K. A. Magalhães, E. N. Araujo, A. M. Santos, M. B. Vanderlei, C. C. L. Souza, M. S. Correia, S. A. Fonseca, J. M. J. S. Pavão, M. A. Souza, J. G. Costa, A. F. Santos, T. J. Matos-Rocha. (2022). Ethnobotanical and ethnopharmacological study of medicinal plants used by a traditional community in Brazil’s northeastern. Brazilian Journal of Biology, 82 https://doi.org/10.1590/1519-6984.237642.

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