Publicado

2026-07-27

Mimosa pudica and Alpinia officinarum extracts: antimicrobial activity anti-inflammatory potential and cytotoxicity

Extractos de Mimosa pudica y Alpinia officinarum: actividad antimicrobiana, potencial antiinflamatorio y citotoxicidad

DOI:

https://doi.org/10.15446/abc.v31n2.124113

Palabras clave:

Anti-infective agents, Botanical extracts, Cell death, Secondary metabolites (en)
Agentes antiinfecciosos, Extractos botánicos, Metabolitos secundarios, Muerte celular (es)

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Autores/as

Mimosa pudica and Alpinia officinarum are largely used in different countries to treat infectious diseases as well as digestive disorders and inflammatory conditions. Despite their long history of traditional use, the pharmacological properties of both plants are poorly described, including their antimicrobial potential. This study investigated the effectiveness of the ethanolic extracts of M. pudica and A. officinarum against bacterial clinical isolates.  The minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) tests and assessed their anti-inflammatory potential and cytotoxicity in vitro. Qualitative methods were used, and ultra-high-performance liquid chromatography coupled to high-resolution tandem mass spectrometry (UHPLC-HRMS/MS) to investigate the phytochemical properties of the extracts. M. pudica and A. officinarum were active against the clinical isolates of Pseudomonas aeruginosa at 8 µg/mL, and both displayed anti-inflammatory properties. UHPLC-HRMS/MS analysis indicated a total of 24 phytocompounds in M. pudica extract and seven in A. officinarum. Only M. pudica presented an acceptable cytotoxicity index for further studies on the antimicrobial potential of chromatographic fractions and isolated phytomolecules. In addition, the data supports research on the safety of A. officinarum in the context of traditional medicine.

Mimosa pudica y Alpinia officinarum se utilizan ampliamente en distintos países para el tratamiento de enfermedades infecciosas, así como de trastornos digestivos y condiciones inflamatorias. A pesar de su larga historia de uso tradicional, las propiedades farmacológicas de ambas plantas están escasamente descritas, incluido su potencial antimicrobiano. En este estudio se investigó la eficacia de los extractos etanólicos de M. pudica y A. officinarum frente a aislados clínicos bacterianos. Se realizaron ensayos de concentración mínima inhibitoria (CMI) y concentración mínima bactericida (CMB), y evaluamos su potencial antiinflamatorio y citotoxicidad in vitro. Se utilizaron métodos cualitativos y cromatografía líquida de ultra-alto rendimiento acoplada a espectrometría de masas de alta resolución en tándem (UHPLC-HRMS/MS) para investigar las propiedades fitoquímicas de los extractos. M. pudica y A. officinarum mostraron actividad frente a los aislados clínicos de Pseudomonas aeruginosa a 8 µg/mL, y ambas presentaron propiedades antiinflamatorias. El análisis UHPLC-HRMS/MS indicó un total de 24 fitocompuestos en el extracto de M. pudica y siete en el de A. officinarum. Solo M. pudica presentó un índice de citotoxicidad aceptable para futuros estudios sobre el potencial antimicrobiano de fracciones cromatográficas y fitomoléculas aisladas. Además, los datos fundamentan investigaciones sobre la seguridad de A. officinarum en el contexto de la medicina tradicional.

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APA

Silva Oliveira, J. da, Dias, N. F. A. H., Silveira, B. L. da, Kohlhoff, M., Ceravolo, I. P. & Dias-Souza, M. V. (2026). Mimosa pudica and Alpinia officinarum extracts: antimicrobial activity anti-inflammatory potential and cytotoxicity. Acta Biológica Colombiana, 31(2), 26–35. https://doi.org/10.15446/abc.v31n2.124113

ACM

[1]
Silva Oliveira, J. da, Dias, N.F.A.H., Silveira, B.L. da, Kohlhoff, M., Ceravolo, I.P. y Dias-Souza, M.V. 2026. Mimosa pudica and Alpinia officinarum extracts: antimicrobial activity anti-inflammatory potential and cytotoxicity. Acta Biológica Colombiana. 31, 2 (may 2026), 26–35. DOI:https://doi.org/10.15446/abc.v31n2.124113.

ACS

(1)
Silva Oliveira, J. da; Dias, N. F. A. H.; Silveira, B. L. da; Kohlhoff, M.; Ceravolo, I. P.; Dias-Souza, M. V. Mimosa pudica and Alpinia officinarum extracts: antimicrobial activity anti-inflammatory potential and cytotoxicity. Acta biol. Colomb. 2026, 31, 26-35.

ABNT

SILVA OLIVEIRA, J. da; DIAS, N. F. A. H.; SILVEIRA, B. L. da; KOHLHOFF, M.; CERAVOLO, I. P.; DIAS-SOUZA, M. V. Mimosa pudica and Alpinia officinarum extracts: antimicrobial activity anti-inflammatory potential and cytotoxicity. Acta Biológica Colombiana, [S. l.], v. 31, n. 2, p. 26–35, 2026. DOI: 10.15446/abc.v31n2.124113. Disponível em: https://revistas.unal.edu.co/index.php/actabiol/article/view/124113. Acesso em: 10 ago. 2026.

Chicago

Silva Oliveira, Josimar da, Naiara Fernanda Avelar Horta Dias, Bianca Luzia da Silveira, Markus Kohlhoff, Isabela Penna Ceravolo, y Marcus Vinícius Dias-Souza. 2026. «Mimosa pudica and Alpinia officinarum extracts: antimicrobial activity anti-inflammatory potential and cytotoxicity». Acta Biológica Colombiana 31 (2):26-35. https://doi.org/10.15446/abc.v31n2.124113.

Harvard

Silva Oliveira, J. da, Dias, N. F. A. H., Silveira, B. L. da, Kohlhoff, M., Ceravolo, I. P. y Dias-Souza, M. V. (2026) «Mimosa pudica and Alpinia officinarum extracts: antimicrobial activity anti-inflammatory potential and cytotoxicity», Acta Biológica Colombiana, 31(2), pp. 26–35. doi: 10.15446/abc.v31n2.124113.

IEEE

[1]
J. da Silva Oliveira, N. F. A. H. Dias, B. L. da Silveira, M. Kohlhoff, I. P. Ceravolo, y M. V. Dias-Souza, «Mimosa pudica and Alpinia officinarum extracts: antimicrobial activity anti-inflammatory potential and cytotoxicity», Acta biol. Colomb., vol. 31, n.º 2, pp. 26–35, may 2026.

MLA

Silva Oliveira, J. da, N. F. A. H. Dias, B. L. da Silveira, M. Kohlhoff, I. P. Ceravolo, y M. V. Dias-Souza. «Mimosa pudica and Alpinia officinarum extracts: antimicrobial activity anti-inflammatory potential and cytotoxicity». Acta Biológica Colombiana, vol. 31, n.º 2, mayo de 2026, pp. 26-35, doi:10.15446/abc.v31n2.124113.

Turabian

Silva Oliveira, Josimar da, Naiara Fernanda Avelar Horta Dias, Bianca Luzia da Silveira, Markus Kohlhoff, Isabela Penna Ceravolo, y Marcus Vinícius Dias-Souza. «Mimosa pudica and Alpinia officinarum extracts: antimicrobial activity anti-inflammatory potential and cytotoxicity». Acta Biológica Colombiana 31, no. 2 (mayo 21, 2026): 26–35. Accedido agosto 10, 2026. https://revistas.unal.edu.co/index.php/actabiol/article/view/124113.

Vancouver

1.
Silva Oliveira J da, Dias NFAH, Silveira BL da, Kohlhoff M, Ceravolo IP, Dias-Souza MV. Mimosa pudica and Alpinia officinarum extracts: antimicrobial activity anti-inflammatory potential and cytotoxicity. Acta biol. Colomb. [Internet]. 21 de mayo de 2026 [citado 10 de agosto de 2026];31(2):26-35. Disponible en: https://revistas.unal.edu.co/index.php/actabiol/article/view/124113

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