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Influence of the Synthesis Route on the Structural and Magnetic Properties of La0.7Sr0.3MnO3 Nanoparticles
Influencia de la ruta de síntesis en las propiedades estructurales y magnéticas de nanopartículas de La0.7Sr0.3MnO3
DOI:
https://doi.org/10.15446/ing.investig.116281Keywords:
ceramic synthesis, hyperthermia applications, manganites, Pechini synthesis, sol-gel synthesis (en)aplicaciones de hipertermia, manganitas, síntesis cerámica, síntesis sol-gel, síntesis Pechini (es)
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Cancer is one of the leading causes of death worldwide, significantly impacting public health, with current treatment options that often have side effects on patients. In this context, magnetic hyperthermia emerges as a non-invasive alternative that utilizes magnetic nanoparticles to generate heat and destroy cancer cells. In this vein, this research sought to synthesize magnetic La0.7Sr0.3MnO3 (LSMO) nanoparticles in order to study the effect of the synthesis route on the production of nanoparticles with optimal properties for biomedical applications. LSMO samples were synthesized via the sol-gel, ceramic, and Pechini methods. These samples were characterized through X-ray diffraction (XRD), small-angle X-ray scattering (SAXS), thermogravimetric analysis (TGA), and vibrating sample magnetometry (VSM) in order to study their structure, morphology, and magnetic behavior. The nanoparticles obtained via the Pechini method exhibited the best crystalline structure, the smallest size, and reduced magnetic properties. This work allowed identifying the ceramic method as the synthesis route that produces nanoparticles suitable for biomedical applications, as demonstrated through the numerical calculation of the specific absorption rate (SAR). The results indicated that the SAR of nanoparticles synthesized using this method is 30 times greater than that of samples synthesized using the other two methods under equal field amplitude and frequency conditions.
El cáncer es una de las principales causas de muerte a nivel mundial y tiene un impacto significativo en la salud pública, con opciones de tratamiento actuales que suelen generar efectos secundarios en los pacientes. En este contexto, la hipertermia magnética surge como una alternativa no invasiva que utiliza nanopartículas magnéticas para generar calor y destruir células cancerígenas. Dado lo anterior, esta investigación buscó sintetizar nanopartículas magnéticas de La0.7Sr0.3MnO3 (LSMO) para estudiar el efecto de la ruta de síntesis en la producción de nanopartículas con propiedades óptimas para aplicaciones biomédicas. Las muestras de LSMO fueron sintetizadas mediante los métodos sol-gel, cerámico y Pechini. Estas muestras fueron caracterizadas mediante difracción de rayos X (XRD), dispersión de rayos X a bajo ángulo (SAXS), análisis termogravimétrico (TGA) y magnetometría de muestra vibrante (VSM), con el fin de estudiar su estructura, morfología y comportamiento magnético. Las nanopartículas obtenidas mediante el método Pechini presentaron la mejor estructura cristalina, el menor tamaño y propiedades magnéticas reducidas. Este trabajo permitió identificar el método cerámico como la ruta de síntesis que produce nanopartículas adecuadas para aplicaciones biomédicas, como se demostró mediante el cálculo numérico de la tasa específica de absorción (SAR). Los resultados indicaron que el SAR de las nanopartículas sintetizadas con este método es 30 veces mayor que el de las muestras sintetizadas mediante los otros dos métodos bajo iguales condiciones de amplitud de campo y frecuencia.
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