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Effect of the Incorporation a Commercial Ricinus com-munis Extract on the Morphology and Properties of Poly(lactic acid) Electrospun Mats
Efecto de la incorporación de un extracto comercial de Ricinus commu-nis en la morfología y las propiedades de las matrices electro-hiladas de poliácido láctico
DOI:
https://doi.org/10.15446/ing.investig.116685Keywords:
nanofibers, phytopharmaceuticals, tissue engineering, drug delivery, biomaterials (en)Nanofibras, Fitofármacos, Ingeniería de tejidos, Liberación de fármacos, Biomateriales (es)
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Chronic skin wounds represent a major challenge in healthcare, necessitating the development of advanced biomaterials capable of promoting healing while maintaining structural integrity. In this study, poly(lactic acid) (PLA) nanofibrous mats were produced via electrospinning and loaded with a commercial extract of Ricinus communis (castor seed oil) as a potential dressing material. The process was performed in two phases: first, the optimal electrospinning parameters (voltage and flow rate) were selected by means of an analysis of variance (ANOVA); subsequently, the castor oil extract was incorporated into the PLA solution. Morphological and chemical analyses were carried out using scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR). The wettability and absorption capacity were evaluated through contact angle measurements and swelling tests. The incorporation of castor oil increased swelling by 60% without affecting the contact angle (132°), indicating reductions in hydrophobicity without compromising surface characteristics. Additionally, the presence of excipients in the commercial extract affected the thermal behavior and crystallinity of the PLA. These findings highlight the potential of electrospun PLA mats containing Ricinus communis extract as functional wound dressing materials, combining biocompatibility, structural performance, and tunable physical properties for chronic wound management.
Las heridas cutáneas crónicas representan un desafío importante en el ámbito de la salud, lo que requiere el desarrollo de biomateriales avanzados capaces de promover la cicatrización a la vez que se mantiene la integridad estructural. En este estudio se produjeron mantas fibrosas de poli(ácido láctico) (PLA) mediante electrohilado y se incorporó un extracto comercial de Ricinus communis (aceite de ricino) como posible material para apósitos. El proceso se realizó en dos fases: primero, se seleccionaron los parámetros óptimos de electrohilado (voltaje y caudal) mediante un análisis de varianza (ANOVA); posteriormente, se incorporó el extracto al polímero. Se realizaron análisis morfológicos y químicos mediante microscopía electrónica de barrido (SEM) y espectroscopía infrarroja por transformada de Fourier (FTIR). La mojabilidad y la capacidad de absorción se evaluaron mediante ensayos de hinchamiento y mediciones del ángulo de contacto. La incorporación del extracto incrementó el grado de hinchamiento en un 60 % sin alterar el ángulo de contacto (132°), indicando una menor hidrofobicidad sin comprometer la superficie. Además, los excipientes del extracto afectaron el comportamiento térmico y la cristalinidad del PLA. Estos resultados destacan el potencial de las mantas electrohiladas de PLA con extracto de Ricinus communis como apósitos funcionales, combinando biocompatibilidad, desempeño estructural y propiedades físicas ajustables para el manejo de heridas crónicas.
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Copyright (c) 2025 Javier Mauricio Anaya Mancipe, José Andrés Anaya Mancipe, Rossana Mara da Silva Moreira Thiré, Marceli do Nascimento da Conceição
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