Correo Electrónico
DNINFOA - SIA
Bibliotecas
Convocatorias
Identidad U.N.
Published
Characterising structural, mechanical and cytotoxic properties of coral-based composite material intended for bone implant applications
Caracterización estructural, mecánica y citotóxica de un material compuesto a base de polvo de coral para posible uso en osteo-implantación
Keywords:
Porites asteroides coral, bone implant, composite material, calcium sulphate, biomaterial characterisation (en)coral Porites asteroides, implantes óseos, material compuesto, sulfato de calcio, caracterización de biomateriales (es)
Studies concerning the application of Porites asteroides coral for bone implant purposes have demonstrated the biological viability of its use. As a complement to previous research regarding the development of bone-powder based composite materials which are useful for such applications, this study was aimed at developing a coral powder-based composite material which would be able to satisfy the appropriate structural, mechanical and cytotoxic properties required for its use. A composite material made of coral powder, calcium sulphate powder and water was therefore developed, and its properties were tested in different compositions. The results showed how the resulting composite material had properties which were comparable to those of human cortical bone (from both a structural and mechanical point of view), as well as being non-toxic below a 0.35 mg/ml critical composite material concentration.
Diferentes estudios referentes a la aplicación del coral tipo Porites asteroides en implantes óseos han demostrado su viabilidad biológica para este fin. Como complemento a investigaciones previas relacionadas con el desarrollo de un material compuesto a base de polvo de hueso susceptible de osteo-implantación, el propósito de este estudio es desarrollar un material compuesto a base de polvo de coral, que satisfaga las propiedades estructurales, mecánicas y citotóxicas requeridas para ser considerado como un material adecuado para este fin. A partir de esto se desarrolló un material a base de polvo de coral, polvo de sulfato de calcio y agua, y se realizaron los respectivos ensayos en diferentes composiciones del mismo. Los resultados generales muestran que el material compuesto desarrollado posee propiedades comparables a las del hueso cortical humano (desde un punto de vista tanto estructural como mecánico) y adicionalmente no muestra evidencias de citotoxicidad si se utiliza en concentraciones menores a 0.35 mg/ml.
Downloads
References
Begley, C.T., Doherty, M.J., Mollan, R.A.B., Wilson, D.J., Comparative study of the osteoinductive properties of bioceramic, coral and processed bone graft substitutes., Biomaterials, Vol. 16, 1995, pp. 1181-1185.
Ben-Nissan, B., Natural bioceramics: From coral to bone and beyond. Current opinion in solid state and materials science 7(4-5), 2003. pp. 283-288.
Braye, F., Irigaray, J.L., Jallot, E., Oudadesse, H., Weber, G., Deschamps, N., Deschamps, C., Frayssinet, P., Tourenne, P., Tixier, H., Terver, S., Lefaivre, J., Amirabaldi, A., Resorption kinetics of osseous substitute: natural coral and synthetic hydroxyapatite., Biomaterials 17, 1996., pp. 1345 -1350.
Cho, B.C., Chung, H.Y., Lee, D.G., Yang, J.D., Park, J.W., Roh, K.H., Kim, G.U., Lee, D.S., Kwon, I.C., Bae, E.H., Jang, K.H., Park, R.W., Kim, I.S., The effect of chitosan bead encapsulating Calcium sulfate as an injectable bone substitute on consolidation in the mandibular distraction osteogenesis of a dog model., Journal of oral and maxillofacial surgery, Vol. 63:12, 2005., pp. 1753-1764.
De Long Jr., W.G., Einhorn, T.A., Koval, K., McKee, M., Smith, W., Sanders, R., Watson, T., Bone grafts and bone graft substitutes in orthopaedic trauma surgery. A critical analysis., The Journal of Bone and Joint Surgery, 2007;89, pp. 649-658.
Jung, H., Song, G., Lee, Y., Baek, J., Ryoo, H., Kim, G., Choung, P., Woo, K.M., Modulation of the resorption and osteoconductivity of a-Calcium sulfate by histone deacetylase inhibitors., Biomaterials 31, 2010., pp. 29-37.
Khavari F, Bajpai PK. Coralline-sulfate bone substitutes. Biomed Sci Instrum. 1993; 29: 65-9.
Lugo S., H., Estudio de la mecánica de corte en materiales celulares: coral tipo Porites Asteroides., Tesis presentada a la Universidad de los Andes, para optar al título de Magister en Ingeniería Mecánica, 2009.
Micheletti, G.F., Tecnología mecánica: Mecanizado por arranque de viruta., Ed. Blume, Barcelona, España, 1980.
Mosmann, T. Rapid colorimetric test for cellular growth and survival - application to proliferation and cytotoxicity tests., J. Immunol, 1983., Métodos 65, 55, 63.
Pecora, G., Andreana, S., Margarone, J.E., Covani, U., Sotto-santi, J.S., Bone regeneration with a Calcium sulfate barrier., Oral surgery, Oral medicine, Oral pathology, Oral radiology, and Endodontology, Vol. 84;4, 1997., pp. 424-429.
Peñaloza, J., Diseño de un material compuesto para implantes óseos., Tesis presentada a la Universidad de los Andes como requisito de grado del programa de pregado en Ingeniería Mecánica, 2007.
Quevedo, S. M., Desarrollo de una metodología para la fabricación de injertos compuestos de polvo de hueso y biopolímero. Tesis presentada a la Universidad de los Andes como requisito de grado del programa de pregrado en Ingeniería Mecánica, 2004.
Reina, D. Y., Implementación de un sistema de manufactura de injertos de polvo de hueso por inyección., Tesis presentada a la Universidad de los Andes como requisito de grado del programa de pregrado en Ingeniería Mecánica, 2005.
Ripamonti, U., Crooks, J., Khoali, L., Roden, L., The induction of bone formation by coral-derived Calcium carbonate/ hydroxyapatite constructs., Biomaterials, Vol. 30, 2009, pp. 1428-1439.
Rojas, F.A., Fabricación de implantes ortopédicos a partir de hueso humano., Tesis presentada a la Universidad Federal de Santa Catarina para optar al título de Doctor of Philosophy, 2000.
Salazar, A., Diseño de un proceso de fabricación de implantes dentales y ortopédicos de polvo de hueso y sulfato de calcio con aplicación industrial., Tesis presentada a la Universidad de los Andes como requisito de grado del programa de pregado en Ingeniería Mecánica, 2009.
Tay, B.K., Patel, V.V., Bradford, D.S. Calcium sulfate - and Calcium phosphate based bone substitutes: Mimicry of the mineral phase of bone., Orthopedic Clinics of North America, Vol. 30;4, 1999., pp. 615-632.
Vuola, J., Göransson, H., Böhling, T., Asko-Seljavaara, S., Bone marrow induced osteogenesis in hydroxyapatite and Calcium carbonate implants., Biomaterials 17, 1996., pp. 1761-1766.
License
Copyright (c) 2011 Angela Samper Gaitán, Fabio Arturo Rojas Mora, Diana María Narváez, Luis Miguel Méndez Moreno
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors or holders of the copyright for each article hereby confer exclusive, limited and free authorization on the Universidad Nacional de Colombia's journal Ingeniería e Investigación concerning the aforementioned article which, once it has been evaluated and approved, will be submitted for publication, in line with the following items:
1. The version which has been corrected according to the evaluators' suggestions will be remitted and it will be made clear whether the aforementioned article is an unedited document regarding which the rights to be authorized are held and total responsibility will be assumed by the authors for the content of the work being submitted to Ingeniería e Investigación, the Universidad Nacional de Colombia and third-parties;
2. The authorization conferred on the journal will come into force from the date on which it is included in the respective volume and issue of Ingeniería e Investigación in the Open Journal Systems and on the journal's main page (https://revistas.unal.edu.co/index.php/ingeinv), as well as in different databases and indices in which the publication is indexed;
3. The authors authorize the Universidad Nacional de Colombia's journal Ingeniería e Investigación to publish the document in whatever required format (printed, digital, electronic or whatsoever known or yet to be discovered form) and authorize Ingeniería e Investigación to include the work in any indices and/or search engines deemed necessary for promoting its diffusion;
4. The authors accept that such authorization is given free of charge and they, therefore, waive any right to receive remuneration from the publication, distribution, public communication and any use whatsoever referred to in the terms of this authorization.
