Publicado

2023-07-24

Production of a phenolic-rich extract of aroeira honey and characterization of its antimicrobial, antitumoral and antioxidant activities

Producción de un extracto rico en fenoles de miel de aroeira y caracterización de sus actividades antimicrobiana, antitumoral y antioxidante

Produção de um extrato rico em fenólicos do mel de aroeira e caracterização de suas atividades antimicrobiana, antitumoral e antioxidante

DOI:

https://doi.org/10.15446/rcciquifa.v52n1.109396

Palabras clave:

Astronium urundeuva (M. Allemão) engl., salmonella, glioblastoma, oxidative stress, arbovirus, coronavirus (en)
Astronium urundeuva (M. Allemão) engl., Salmonella, glioblastoma, estrés oxidativo, arbovírus, coronavírus (es)
Astronium urundeuva (M. Allemão) engl., salmonella, glioblastoma, estresse oxidativo, arbovírus, coronavírus (pt)

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Autores/as

  • William Gustavo Lima Universidade Federal de Minas Gerais
  • Felipe Rocha da Silva Santos Universidade Federal de Minas Gerais
  • Vinícius Oliveira de Faria Fundação Ezequiel Dias (FUNED)
  • Nayara Alves de Souza Universidade Federal de São João del Rei
  • Luiz Pedro de Souza-Costa Universidade Federal de Minas Gerais
  • Débora Cristina Sampaio de Assis Universidade Federal de Minas Gerais
  • Waleska Stephanie da Cruz Nizer Carleton University
  • Jaqueline Maria Siqueira Ferreira Universidade Federal de São João del Rei
  • Magna Cristina de Paiva Universidade Federal de São João del Rei
  • Júlio César Moreira Brito Fundação Ezequiel Dias (FUNED)

Objective: a phenolic-rich extract of Astronium urundeuva honey (PhEAH) was
produced and its pharmacological proprieties were determined. Method: PhEAH
was prepared using a solid-phase extraction column. Next, antibacterial and antifungal
activities were evaluated by broth microdilution method and the antioxidant
effect was investigated using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay. Urethral
catheter sensitized with PhEAH were produced and its anti-adhesive and anti-biofilm
effect determined. Finally, antitumoral and antiviral activities were studded using
3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) test. Results:
PhEAH showed an elevated total phenol concentration (PhEAH: 18.7±0.4 mg GA/g vs. fresh honey: 0.99±0.005 mg GA/g). Although PhEAH did not show significant
antifungal and antiviral effects, it was moderately active against Gram-negative bacilli
(Klebsiella aerogenes, K. pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa and
Enterobacter cloacae) and showed increased antibacterial activity against salmonellosis
pathogens (Salmonella Typhimurium and Salmonella Enteritidis). PhEAH-impregnated
urethral catheters inhibited the growth of various pathogenic bacteria and
impaired the ability of P. aeruginosa to colonize and adhere to it. In addition to its antimicrobial
activity, PhEAH presented antioxidant properties and reduced the viability
of human glioblastoma cells. Conclusion: in conclusion, our study shows that PhEAH
contains large amounts of phenolic compounds, which are associated with its antibacterial,
anti-adhesive, antioxidant, and antitumor effects.

Objetivo: se produjo un extracto rico en fenoles de miel de Astronium urundeuva
(PhEAH) y se determinaron sus propiedades farmacológicas. Métodos: PhEAH se
preparó utilizando una columna de extracción en fase sólida. Luego, se evaluaron las
actividades antibacteriana y antifúngica mediante el método de microdilución en caldo
y se investigó el efecto antioxidante mediante el ensayo de 2,2-difenil-1-picrilhidrazilo
(DPPH). Se fabricaron catéteres uretrales sensibilizados con PhEAH y se determinó
su efecto antiadhesivo y antibiofilm. Finalmente, las actividades antitumoral y antiviral
se evaluaron mediante la prueba de bromuro de 3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolio
(MTT). Resultados: PhEAH mostró una alta concentración de fenoles
totales (PhEAH: 18,7±0,4 mg AG/g vs. miel fresca: 0,99±0,005 mg AG/g). Aunque
PhEAH no mostró efectos antifúngicos y antivirales significativos, fue moderadamente
activo contra los bacilos Gram-negativos (Klebsiella aerogenes, K. pneumoniae,
Proteus mirabilis, Pseudomonas aeruginosa y Enterobacter cloacae) y mostró una mayor
actividad antibacteriana contra los patógenos de la salmonelosis (Salmonella Typhimurium
y Salmonella enteriditis). Los catéteres uretrales impregnados con PhEAH
inhibieron el crecimiento de varias bacterias patógenas y afectaron la capacidad de P.
aeruginosa para colonizar y adherirse a ella. Además de su actividad antimicrobiana, PhEAH mostró propiedades antioxidantes y redujo la viabilidad de las células de glioblastoma
humano. Conclusión: en conclusión, nuestro estudio muestra que PhEAH
contiene grandes cantidades de compuestos fenólicos, los cuales están asociados con
sus efectos antibacterianos, antiadhesivos, antioxidantes y antitumorales.

Objetivos: um extrato rico em fenólicos do mel de Astronium urundeuva (PhEAH)
foi produzido e suas propriedades farmacológicas foram determinadas. Métodos:
o PhEAH foi preparado usando uma coluna de extração em fase sólida. Em
seguida, as atividades antibacteriana e antifúngica foram avaliadas pelo método
de microdiluição em caldo e o efeito antioxidante foi investigado pelo ensaio de
2,2-difenil-1-picrilhidrazil (DPPH). Cateteres uretrais sensibilizados com PhEAH
foram produzidos e seu efeito antiadesivo e antibiofilme determinado. Finalmente,
as atividades antitumoral e antiviral foram avaliadas usando o teste de brometo
de 3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazólio (MTT). Resultados: PhEAH
mostrou uma concentração de fenol total elevada (PhEAH: 18,7±0,4 mg GA/g
vs. mel fresco: 0,99±0,005 mg GA/g). Embora o PhEAH não tenha apresentado
efeitos antifúngicos e antivirais significativos, foi moderadamente ativo contra
bacilos Gram-negativos (Klebsiella aerogenes, K. pneumoniae, Proteus mirabilis,
Pseudomonas aeruginosa e Enterobacter cloacae) e mostrou atividade antibacteriana
aumentada contra patógenos de salmonelose (Salmonella Typhimurium e Salmonella
Enteritidis). Cateteres uretrais impregnados com PhEAH inibiram o crescimento
de várias bactérias patogênicas e prejudicaram a capacidade de P. aeruginosa de
colonizar e aderir a ela. Além de sua atividade antimicrobiana, PhEAH apresentou
propriedades antioxidantes e reduziu a viabilidade de células de glioblastoma
humano. Conclusão: em conclusão, nosso estudo mostra que o PhEAH contém
grandes quantidades de compostos fenólicos, que estão associados aos seus efeitos
antibacteriano, antiadesivo, antioxidante e antitumoral.

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Cómo citar

APA

Lima, W. G., Rocha da Silva Santos, F., Oliveira de Faria, V., Alves de Souza, N., de Souza-Costa, L. P., Sampaio de Assis, D. C., da Cruz Nizer, W. S., Siqueira Ferreira, J. M., de Paiva, M. C. y Moreira Brito, J. C. (2023). Production of a phenolic-rich extract of aroeira honey and characterization of its antimicrobial, antitumoral and antioxidant activities. Revista Colombiana de Ciencias Químico-Farmacéuticas, 52(1). https://doi.org/10.15446/rcciquifa.v52n1.109396

ACM

[1]
Lima, W.G., Rocha da Silva Santos, F., Oliveira de Faria, V., Alves de Souza, N., de Souza-Costa, L.P., Sampaio de Assis, D.C., da Cruz Nizer, W.S., Siqueira Ferreira, J.M., de Paiva, M.C. y Moreira Brito, J.C. 2023. Production of a phenolic-rich extract of aroeira honey and characterization of its antimicrobial, antitumoral and antioxidant activities. Revista Colombiana de Ciencias Químico-Farmacéuticas. 52, 1 (jul. 2023). DOI:https://doi.org/10.15446/rcciquifa.v52n1.109396.

ACS

(1)
Lima, W. G.; Rocha da Silva Santos, F.; Oliveira de Faria, V.; Alves de Souza, N.; de Souza-Costa, L. P.; Sampaio de Assis, D. C.; da Cruz Nizer, W. S.; Siqueira Ferreira, J. M.; de Paiva, M. C.; Moreira Brito, J. C. Production of a phenolic-rich extract of aroeira honey and characterization of its antimicrobial, antitumoral and antioxidant activities. Rev. Colomb. Cienc. Quím. Farm. 2023, 52.

ABNT

LIMA, W. G.; ROCHA DA SILVA SANTOS, F.; OLIVEIRA DE FARIA, V.; ALVES DE SOUZA, N.; DE SOUZA-COSTA, L. P.; SAMPAIO DE ASSIS, D. C.; DA CRUZ NIZER, W. S.; SIQUEIRA FERREIRA, J. M.; DE PAIVA, M. C.; MOREIRA BRITO, J. C. Production of a phenolic-rich extract of aroeira honey and characterization of its antimicrobial, antitumoral and antioxidant activities. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 52, n. 1, 2023. DOI: 10.15446/rcciquifa.v52n1.109396. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/109396. Acesso em: 19 abr. 2025.

Chicago

Lima, William Gustavo, Felipe Rocha da Silva Santos, Vinícius Oliveira de Faria, Nayara Alves de Souza, Luiz Pedro de Souza-Costa, Débora Cristina Sampaio de Assis, Waleska Stephanie da Cruz Nizer, Jaqueline Maria Siqueira Ferreira, Magna Cristina de Paiva, y Júlio César Moreira Brito. 2023. «Production of a phenolic-rich extract of aroeira honey and characterization of its antimicrobial, antitumoral and antioxidant activities». Revista Colombiana De Ciencias Químico-Farmacéuticas 52 (1). https://doi.org/10.15446/rcciquifa.v52n1.109396.

Harvard

Lima, W. G., Rocha da Silva Santos, F., Oliveira de Faria, V., Alves de Souza, N., de Souza-Costa, L. P., Sampaio de Assis, D. C., da Cruz Nizer, W. S., Siqueira Ferreira, J. M., de Paiva, M. C. y Moreira Brito, J. C. (2023) «Production of a phenolic-rich extract of aroeira honey and characterization of its antimicrobial, antitumoral and antioxidant activities», Revista Colombiana de Ciencias Químico-Farmacéuticas, 52(1). doi: 10.15446/rcciquifa.v52n1.109396.

IEEE

[1]
W. G. Lima, «Production of a phenolic-rich extract of aroeira honey and characterization of its antimicrobial, antitumoral and antioxidant activities», Rev. Colomb. Cienc. Quím. Farm., vol. 52, n.º 1, jul. 2023.

MLA

Lima, W. G., F. Rocha da Silva Santos, V. Oliveira de Faria, N. Alves de Souza, L. P. de Souza-Costa, D. C. Sampaio de Assis, W. S. da Cruz Nizer, J. M. Siqueira Ferreira, M. C. de Paiva, y J. C. Moreira Brito. «Production of a phenolic-rich extract of aroeira honey and characterization of its antimicrobial, antitumoral and antioxidant activities». Revista Colombiana de Ciencias Químico-Farmacéuticas, vol. 52, n.º 1, julio de 2023, doi:10.15446/rcciquifa.v52n1.109396.

Turabian

Lima, William Gustavo, Felipe Rocha da Silva Santos, Vinícius Oliveira de Faria, Nayara Alves de Souza, Luiz Pedro de Souza-Costa, Débora Cristina Sampaio de Assis, Waleska Stephanie da Cruz Nizer, Jaqueline Maria Siqueira Ferreira, Magna Cristina de Paiva, y Júlio César Moreira Brito. «Production of a phenolic-rich extract of aroeira honey and characterization of its antimicrobial, antitumoral and antioxidant activities». Revista Colombiana de Ciencias Químico-Farmacéuticas 52, no. 1 (julio 24, 2023). Accedido abril 19, 2025. https://revistas.unal.edu.co/index.php/rccquifa/article/view/109396.

Vancouver

1.
Lima WG, Rocha da Silva Santos F, Oliveira de Faria V, Alves de Souza N, de Souza-Costa LP, Sampaio de Assis DC, da Cruz Nizer WS, Siqueira Ferreira JM, de Paiva MC, Moreira Brito JC. Production of a phenolic-rich extract of aroeira honey and characterization of its antimicrobial, antitumoral and antioxidant activities. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 24 de julio de 2023 [citado 19 de abril de 2025];52(1). Disponible en: https://revistas.unal.edu.co/index.php/rccquifa/article/view/109396

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1. Douglas Galhardo, Alessandra Fernandes Gonçalves Benites, Daiani Rodrigues Moreira, Vagner de Alencar Arnaut de Toledo. (2025). Health Benefits of Honey and Propolis - Scientific Evidence and Medicinal Uses [Working Title]. https://doi.org/10.5772/intechopen.1009782.

2. Victor M. M. de Souza, Géssica E. do N. Costa, Rodrigo F. dos S. Silva, Ricardo M. Ramos, Ézio R. A. de Sá. (2024). In Silico Investigation of the Constituents of Aroeira Honey (Astronium urundeuva) and the Binding Affinity with Important Proteins of M. leprae and M. tuberculosis. Molecular Modeling Connect, 1(1), p.1. https://doi.org/10.69709/MolModC.2024.113103.

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