Publicado

2020-01-01

Use of statins and the risk of developing pre-diabetes and diabetes: a longitudinal study in individuals aged 40 years or older

Uso de estatina e risco de desenvolver pré-diabetes e diabetes: um estudo longitudinal em pessoas com 40 anos ou mais

DOI:

https://doi.org/10.15446/rcciquifa.v49n1.85168

Palabras clave:

Diabetes mellitus, statins, adverse drug reactions (en)
Diabetes mellitus, estatinas, eventos adversos (pt)

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Background: Statins are the main therapeutic option for the control of dyslipidemias and cardiovascular prevention. However, studies indicate the possibility of the use of statins cause increases in blood glucose levels. Aim: The aim of the study was to analyze the use of statin and the risk of developing pre-diabetes (DM) or DM. Methods: This was a cohort study conducted with individuals aged 40 years or older, living in a medium-sized municipality in the north of Paraná, Brazil. Data were obtained through individual interviews and laboratory tests in the years 2011 (baseline) and 2015 (follow-up). Dependent variables were the development of DM (yes; no) and the development of pre-DM or DM (yes; no). The independent variable was the use of statins (no use; use only in 2011; use only in 2015; use in 2011 and 2015). Poisson (loglinear) regression analysis was used to calculate the relative risk (RR) and 95% confidence intervals (95% CI) in generalized linear models. Results: An association was observed between the use of statins and the incidence of DM (RR 2.89, 95% CI: 1.59-5.24) and the incidence of pre-DM or DM (RR 2.01, 95% CI: 1.39-2.92) for the group of individuals who used statins only in 2015. Conclusions: The present study identified an association between the use of statins and the incidence of pre-DM and DM only for those who used them exclusively in 2015.

Introdução: As estatinas são a principal opção terapêutica para o controle de dislipidemias e prevenção cardiovascular. No entanto, estudos indicam a possibilidade do uso de estatinas causar aumentos nos níveis de glicose no sangue. Objetivo: O objetivo do estudo foi analisar o uso de estatina e o risco de desenvolver pré-diabetes (DM) ou DM. Métodos: Estudo de coorte realizado com indivíduos com 40 anos ou mais de idade, residentes em um município de médio porte no norte do Paraná. Os dados foram obtidos por meio de entrevistas individuais e exames laboratoriais nos anos de 2011 (linha de base) e 2015 (acompanhamento). As variáveis dependentes foram o desenvolvimento de DM (sim; não) e o desenvolvimento de pré-DM ou DM (sim; não). A variável independente foi o uso de estatinas (sem uso; uso apenas em 2011; uso apenas em 2015; uso em 2011 e 2015). A análise de regressão de Poisson (log-linear) foi utilizada para calcular o risco relativo (RR) e os intervalos de confiança de 95% (IC95%) em modelos lineares generalizados. Resultados: Observou-se associação entre o uso de estatinas e a incidência de DM (RR 2,89, IC 95%: 1,59-5,24) e a incidência de pré-DM ou DM (RR 2,01, IC 95%: 1,39-2,92) para o grupo de indivíduos que usaram estatinas apenas em 2015. Conclusões: O presente estudo identificou associação entre o uso de estatinas e a incidência de pré-DM e DM apenas para aqueles que as usaram exclusivamente em 2015.

Referencias

R. Lozano, M. Naghavi, K. Foreman, S. Lim, K. Shibuya, V. Aboyans, et al., Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010, Lancet, 380(9859), 2095-2128 (2012).

M.A. de Vera, V. Bhole, L.C. Burns, D. Lacaille, Impact of statin adherence on cardiovascular disease and mortality outcomes: a systematic review, Br. J. Clin. Pharmacol., 78(4), 684-98 (2014).

C. Baigent, L. Blackwell, J. Emberson, L.E. Holland, C. Reith, et al., Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170, 000 participants in 26 randomised trial, Lancet, 376(9753),1670-1681 (2010).

A.A. Faludi, M.C.O. Izar, J.F.K. Saraiva, A.P.M. Chacra, H.T. Bianco, et al., Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose-2017, Arq. Bras. Cardiol., 109(2 Supl 1),1-76 (2017).

T.P. Bersot, Terapia farmacológica para a hipercolesterolemia e a dislipidemia. In: L.L. Brunton, B.A. Chabner, B. C.Knollmann. Eds. As bases farmacológicas da terapêutica de Goodman e Gilman. Tradução de A. Langeloh et al. 12ª ed. Porto Alegre, AMGH, 2012, pp. 877-908.

E.J. Mills, B. Rachlis, P. Wu, P.J. Devereaux, P. Arora, D. Perri, Primary prevention of cardiovascular mortality and events with statin treatments. A network meta-analysis involving more than 65 000 patients, J. Am. Coll. Cardiol., 52(22), 1769-1781 (2008).

J. Afilalo, G. Duque, R. Steele, J.W. Jukema, A.J. de Craen, M.J. Eisenberg, Statins for secondary prevention in elderly patients: A hierarchical bayesian meta-analysis, J. Am. Coll. Cardiol., 51(1), 37-45 (2008).

J.J. Brugts, T. Yetgin, S.E. Hoeks, A.M. Gotto, J. Shepherd, R.G. Westendorp, et al., The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials, BMJ, 338, b2376 (2009).

S.N. Rajpathak, D.J. Kumbhani, J. Crandall, N. Barzilai, M. Alderman, P.M. Ridker, Statin therapy and risk of developing type 2 diabetes: a meta-analysis, Diabetes Care, 32(10), 1924-1929 (2009).

D. Yoon, S.S. Sheen, S. Lee, Y.J. Choi, R.W. Park, H.S. Lim, Statins and risk for new-onset diabetes mellitus: A real-world cohort study using a clinical research database, Medicine (Baltimore), 95(46), e5429 (2016).

J.P. Crandall, K. Mather, S.N. Rajpathak, R.B. Goldberg, K. Watson, S. Foo, et al., Statin use and risk of developing diabetes: results from the Diabetes Prevention Program, BMJ Open Diabetes Res. Care, 5(1), e000438 (2017).

D. Preiss, S.R. Seshasai, P. Welsh, S.A. Murphy, J.E. Ho, D.D. Waters, et al., Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis, JAMA, 305(24), 2556-2564 (2011).

M. Jones, S. Tett, G.M. Peeters, G.D. Mishra, A. Dobson, New-onset diabetes after statin exposure in elderly women: the Australian longitudinal study on women’s health, Drugs Aging, 34(3),203-209 (2017).

International Diabetes Federation, The IDF Diabetes Atlas, 8. ed., Available from: https://reports.instantatlas.com/report/view/704ee0e6475b4af885051bcec15f0e2c/BRA. Accessed September 17, 2018.

R.K.T. Souza, M.S.S. Bortoletto, M.R. Loch, A.D. González, T. Matsuo, M.A.S. Cabrera, et al., Prevalência de fatores de risco cardiovascular em pessoas com 40 anos ou mais de idade, em Cambé, Paraná (2011), estudo de base populacional, Epidemiol. Serv. Saude, 22(3), 435-444 (2013).

Sociedade Brasileira de Diabetes, Diretrizes da Sociedade Brasileira de Diabetes 2017-2018, Clannad, São Paulo, 2017.

M.V.B. Malachias, M.A.M. Gomes, F. Nobre, A. Alessi, A.D. Feitosa, E.B. Coelho, 7ª Diretriz Brasileira de Hipertensão Arterial. Arq. Bras. Cardiol., 107(3 Supl.3), 1-83 (2016).

Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), JAMA, 285(19), 2486-2497 (2001).

World Health Organization, Obesity: preventing and managing the global epidemic, World Health Organization, Geneva, 2000.

R Core Team, R: A language and environment for statistical computing, R Foundation for Statistical Computing, Vienna, Austria, 2015.

P. Tuso, Prediabetes and lifestyle modification: time to prevent a preventable disease, Perm. J., 18(3), 88-93 (2014).

J.Y. Cui, R.R. Zhou, S. Han, T.S. Wang, L.Q. Wang, X.H. Xie, Statin therapy on glycemic control in type 2 diabetic patients: A network meta-analysis, J. Clin. Pharm. Ther., 43(4), 556-570 (2018).

S.W. Rha, B.G. Choi, H.S. Seo, S.H. Park, J.Y. Park, K.Y. Chen, et al., Impact of statin use on development of new-onset diabetes mellitus in Asian population, Am. J. Cardiol.,117(3), 382-387 (2016).

O. Currie, D. Mangin, J. Williman, B. McKinnon-Gee, P. Bridgford, The comparative risk of new-onset diabetes after prescription of drugs for cardiovascular risk prevention in primary care: a national cohort study, BMJ Open, 3(11), e003475 (2013).

A.F. Macedo, I. Douglas, L. Smeeth, H. Forbes, S. Ebrahim, Statins and the risk of type 2 diabetes mellitus: cohort study using the UK clinical practice research datalink, BMC Cardiovasc. Disord., 14, 85 (2014).

M. Laakso, J. Kuusisto, Diabetes secondary to treatment with statins, Curr. Diab. Rep., 17(2), 10 (2017).

N. Sattar, D. Preiss, H.M. Murray, P. Welsh, B.M. Buckley, A.J. de Craen, Statins and risk of incident diabetes: a collaborative meta-analysis of randomized statin trials, Lancet, 375(9716), 735-742 (2010).

D.J. Betteridge, R. Carmena, The diabetogenic action of statins - mechanisms and clinical implications, Nat. Rev. Endocrinol., 12(2), 99-110 (2016).

Cómo citar

APA

Curiaki, G., Durán González, A., Aparecido Sarria Cabrera, M., Molino Guidoni, C. y Girotto, E. (2020). Use of statins and the risk of developing pre-diabetes and diabetes: a longitudinal study in individuals aged 40 years or older. Revista Colombiana de Ciencias Químico-Farmacéuticas, 49(1). https://doi.org/10.15446/rcciquifa.v49n1.85168

ACM

[1]
Curiaki, G., Durán González, A., Aparecido Sarria Cabrera, M., Molino Guidoni, C. y Girotto, E. 2020. Use of statins and the risk of developing pre-diabetes and diabetes: a longitudinal study in individuals aged 40 years or older. Revista Colombiana de Ciencias Químico-Farmacéuticas. 49, 1 (ene. 2020). DOI:https://doi.org/10.15446/rcciquifa.v49n1.85168.

ACS

(1)
Curiaki, G.; Durán González, A.; Aparecido Sarria Cabrera, M.; Molino Guidoni, C.; Girotto, E. Use of statins and the risk of developing pre-diabetes and diabetes: a longitudinal study in individuals aged 40 years or older. Rev. Colomb. Cienc. Quím. Farm. 2020, 49.

ABNT

CURIAKI, G.; DURÁN GONZÁLEZ, A.; APARECIDO SARRIA CABRERA, M.; MOLINO GUIDONI, C.; GIROTTO, E. Use of statins and the risk of developing pre-diabetes and diabetes: a longitudinal study in individuals aged 40 years or older. Revista Colombiana de Ciencias Químico-Farmacéuticas, [S. l.], v. 49, n. 1, 2020. DOI: 10.15446/rcciquifa.v49n1.85168. Disponível em: https://revistas.unal.edu.co/index.php/rccquifa/article/view/85168. Acesso em: 22 ene. 2025.

Chicago

Curiaki, Gustavo, Alberto Durán González, Marcos Aparecido Sarria Cabrera, Camilo Molino Guidoni, y Edmarlon Girotto. 2020. «Use of statins and the risk of developing pre-diabetes and diabetes: a longitudinal study in individuals aged 40 years or older». Revista Colombiana De Ciencias Químico-Farmacéuticas 49 (1). https://doi.org/10.15446/rcciquifa.v49n1.85168.

Harvard

Curiaki, G., Durán González, A., Aparecido Sarria Cabrera, M., Molino Guidoni, C. y Girotto, E. (2020) «Use of statins and the risk of developing pre-diabetes and diabetes: a longitudinal study in individuals aged 40 years or older», Revista Colombiana de Ciencias Químico-Farmacéuticas, 49(1). doi: 10.15446/rcciquifa.v49n1.85168.

IEEE

[1]
G. Curiaki, A. Durán González, M. Aparecido Sarria Cabrera, C. Molino Guidoni, y E. Girotto, «Use of statins and the risk of developing pre-diabetes and diabetes: a longitudinal study in individuals aged 40 years or older», Rev. Colomb. Cienc. Quím. Farm., vol. 49, n.º 1, ene. 2020.

MLA

Curiaki, G., A. Durán González, M. Aparecido Sarria Cabrera, C. Molino Guidoni, y E. Girotto. «Use of statins and the risk of developing pre-diabetes and diabetes: a longitudinal study in individuals aged 40 years or older». Revista Colombiana de Ciencias Químico-Farmacéuticas, vol. 49, n.º 1, enero de 2020, doi:10.15446/rcciquifa.v49n1.85168.

Turabian

Curiaki, Gustavo, Alberto Durán González, Marcos Aparecido Sarria Cabrera, Camilo Molino Guidoni, y Edmarlon Girotto. «Use of statins and the risk of developing pre-diabetes and diabetes: a longitudinal study in individuals aged 40 years or older». Revista Colombiana de Ciencias Químico-Farmacéuticas 49, no. 1 (enero 1, 2020). Accedido enero 22, 2025. https://revistas.unal.edu.co/index.php/rccquifa/article/view/85168.

Vancouver

1.
Curiaki G, Durán González A, Aparecido Sarria Cabrera M, Molino Guidoni C, Girotto E. Use of statins and the risk of developing pre-diabetes and diabetes: a longitudinal study in individuals aged 40 years or older. Rev. Colomb. Cienc. Quím. Farm. [Internet]. 1 de enero de 2020 [citado 22 de enero de 2025];49(1). Disponible en: https://revistas.unal.edu.co/index.php/rccquifa/article/view/85168

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