Process simulation for xylitol production from brewer’s spent grain in a Colombian biorefinery. Part 1: Xylose production from arabinoxilans extracted by the alkaline pretreatment of BSG
Simulación de proceso para la producción de xilitol a partir de bagazo de cebada en una biorrefinería en Colombia. Parte 1: producción de xilosa a partir de arabinoxilanos extraídos en el pretratamiento alcalino de BSG
DOI:
https://doi.org/10.15446/ing.investig.v39n1.70080Keywords:
Simulation, brewer’s spent grain, xylitol, biorefinery (en)Simulación, cascarilla de cebada, xilitol, biorrefinería (es)
This work presents the simulation in Aspen Plusr of a process to obtain arabinoxylans (AX) from Brewer’s Spent Grain (BSG), which is the major byproduct of the brewing industry. The process is divided into two stages: alkaline pretreatment and enzymatic hydrolysis. These stages cover the extraction of proteins and AX from BSG using an alkaline pretreatment and enzymatic hydrolysis of the AX separated from the liquid stream to obtain xylose, i.e. the substrate required for the fermentation to xylitol. Simulation results show that xylose obtained corresponds to 8,5% of the dry weight of the raw material, obtaining a yield of 58%. Several streams of byproducts were obtained, such as proteins, polypeptides, amino acids, phenolic compounds and lignocellulosic residues that can be valorized in other processes. Simulation was performed in the context of a biorefinery in Colombia.
Este trabajo presenta la simulación en Aspen Plusr del proceso para obtener arabinoxilanos (AX) a partir de bagazo de cebada, principal subproducto de la industria cervecera. El proceso se divide en dos etapas: pretratamiento alcalino e hidrólisis enzimática. En la primera etapa, se logra la extracción de proteínas y AX de la cascarilla de cebada y en la segunda etapa, se hidrolizan enzimáticamente los AX separados de la corriente líquida hasta obtenerse xilosa, el sustrato requerido para el xilitol. Los resultados de la simulación mostraron que la xilosa obtenida corresponde al 8,5 % del peso de la materia prima, obteniéndose un rendimiento del 58 %. Adicionalmente se obtienen varias corrientes de subproductos como proteínas, polipéptidos, aminoácidos, compuestos fenólicos y residuos concentrados en lignina y celulosa, los cuales se pueden valorizar en otros procesos. La simulación del proceso se realizó en el contexto de una biorrefinería en Colombia.
References
Dávila, A. J., Rosenberg M., and Cardona, C. A., (2016). A biorefinery approach for the production of xylitol, ethanol and polyhydroxybutyrate from brewer’s spent grain. AIMS Agriculture and Food, 1(1), 52–66. DOI: 10.3934/agrfood.2016.1.52
Bhutto, A. W., Qureshi, K., Harijan, K., Abro, R., Abbas, T., Bazmi, A. A., Yu, G. (2017). Insight into progress in pre-treatment of lignocellulosic biomass. Energy, 122, 724–745. DOI: 10.1016/j.energy.2017.01.005
Cherubini, F. (2010). The biorefinery concept: Using biomass instead of oil for producing energy and chemicals. Energy Conversion and Management, 51(7), 1412–1421. DOI: 10.1016/j.enconman.2010.01.015
Gil, I. D., López, J. R. G., Zapata, J. L. G., Robayo, A. L., and Niño, G. R. (2015). Process Analysis and Simulation in Chemical Engineering. Switzerland: Springer Publishing. DOI: 10.1007/978-3-319-14812-0
Hermann, B. G., Blok, K., and Patel, M. K. (2007). Producing bio-based bulk chemicals using industrial biotechnology saves energy and combats climate change. Environmental Science and Technology, 41(22), 7915–7921. DOI: 10.1021/es062559q
Jong, E., Higson, A., Walsh, P., and Wellisch, M. (2011). Bio-based Chemicals - Value Added Products from Biorefineries (Task 42: Biorefineries). A Report Prepared for IEA Bioenergy. Retrieved from: https://www.ieabioenergy.com/wp-content/uploads/2013/10/Task-42-Biobased-Chemicals-value-added-products-from-biorefineries.pdf
Linko, R., Lapveteläinen, A., Laakso, P., and Kallio, H. (1989). Protein composition of a high-protein barley flour and barley grain. Cereal Chem, 66, 478–482. Retrieved from: https://pdfs.semanticscholar.org/e782/b55d717ec48177bc8a28bd39f7f60dc08515.pdf
Meneses, N. G. T., Martins, S., Teixeira, J. A., and Mussatto, S. I. (2013). Influence of extraction solvents on the recovery of antioxidant phenolic compounds from brewer’s spent grains. Separation and Purification Technology, 108, 152–158. DOI: 10.1016/j.seppur.2013.02.015
Menon, V., and Rao, M. (2012). Trends in bioconversion of lignocellulose: Biofuels, platform chemicals & biorefinery concept. Progress in Energy and Combustion Science, 38(4), 522–550. DOI: 10.1016/j.pecs.2012.02.002
Mussatto, S and Roberto, C. (2005). Acid hydrolysis and fermentation of brewer’s spent grain to produce xylitol, Journal of the Sicence of Food and Agriculture, 85(14), 2453-2460. DOI: 10.1002/jsfa.2276
Mussatto, S. I., Dragone, G., and Roberto, I. C. (2006). Brewers’ spent grain: generation, characteristics and potential applications. Journal of Cereal Science, 43(1), 1–14. DOI: 10.1016/j.jcs.2005.06.001
Mussatto, S.I., and Roberto, I.C., (2008). Establishment of the optimum initial xylose concentration and nutritional supplementation of brewer’s spent grain hydrolysate for xylitol production by Candida guilliermondii. Process Biochemestry, 43 (5), 540-546. DOI: 10.1016/j.procbio.2008.01.013
Mussatto, S. I., Moncada, J., Roberto, I. C., and Cardona, C. A. (2013). Techno-economic analysis for brewer’s spent grains use on a biorefinery concept: The Brazilian case. Bioresource Technology, 148, 302–310. DOI: 10.1016/j.biortech.2013.08.046
Ravella, S.R., Gallagher, J., Fish, S., and Prakasham, R.S. (2012). Overview on Commercial Production of Xylitol, Economic Analysis and Market Trends. In: da Silva S., Chandel A. (Eds.) D-Xylitol. Berlin, Alemania: Springer. DOI: 10.1007/978-3-642-31887-0_13
Reinold, M. R. (1997). Manual Prático de Cervejaria. Sao Paulo: ADEN Editora e Comunicações Ltda.
Reis, S. F., Coelho, E., Coimbra, M. A., and Abu-Ghannam, N. (2015). Influence of grain particle sizes on the structure of arabinoxylans from brewer’s spent grain. Carbohydrate Polymers, 130, 222–226. DOI: 10.1016/j.carbpol.2015.05.031
Rojas-Pérez, L. C. (2018). Valorización de la cascarilla de cebada del proceso cervecero para la producción de xilitol. (Ph.D. Thesis, Universidad Nacional de Colombia - Campus Bogotá). Retrieved from: http://bdigital.unal.edu.co/69970/1/Tesis%20Doctorado%20Lilia%20Carolina%20Rojas%20P%C3%A9rez.pdf
Vieira, E., Rocha, M. A. M., Coelho, E., Pinho, O., Saraiva, J. A., Ferreira, I. M. P. L. V. O., and Coimbra, M. A. (2014a). Valuation of brewer’s spent grain using a fully recyclable integrated process for extraction of proteins and arabinoxylans. Industrial Crops and Products, 52, 136–143. DOI: 10.1016/j.indcrop.2013.10.012
Wooley, R. J., and Putsche, V. (1996). Development of an ASPEN PLUS Physical Property Database for Biofuels Components. Golden, Colorado: National Renewable Energy Laboratory. Retrieved from: https://www.nrel.gov/docs/legosti/old/20685.pdf
Xiros, C., and Christakopoulos, P. (2012). Biotechnological potential of brewers spent grain and its recent applications. Waste and Biomass Valorization, 3(2), 213–232. DOI: 10.1007/s12649-012-9108-8
Xu, J.-K., and Sun, R.-C. (2016). Recent Advances in Alkaline Pretreatment of Lignocellulosic Biomass. In S. I. Mussatto. (Ed.), Biomass Fractionation Technologies for a Lignocellulosic Feedstock Based Biorefinery (pp. 431–459). Amsterdam, Holanda: Elsevier. DOI: 10.1016/B978-0-12-802323-5.00019-0
How to Cite
APA
ACM
ACS
ABNT
Chicago
Harvard
IEEE
MLA
Turabian
Vancouver
Download Citation
CrossRef Cited-by
1. Carlos Aristizabal, Pedro Alvarado, Andrés Vargas. (2020). Biorefinery Concept Applied to Phytochemical Extraction and Bio-Syngas Production using Agro-Industrial Waste Biomass: A Review. Ingeniería e Investigación, 40(2) https://doi.org/10.15446/ing.investig.v40n2.82539.
2. Dimastyaji Yusron Nurseta, Jesus Manuel Garcia-Vargas, Luz Sanchez-Silva. (2025). Sustainable phenol production: Evaluating high phenolic bio-oil from olive pomace via fast pyrolysis combined with chemical and thermochemical pretreatment. Sustainable Production and Consumption, 54, p.75. https://doi.org/10.1016/j.spc.2024.12.020.
3. Kerstin Milew, Sophie Manke, Sandra Grimm, Roland Haseneder, Volker Herdegen, Andreas S. Braeuer. (2022). Application, characterisation and economic assessment of brewers’ spent grain and liquor. Journal of the Institute of Brewing, 128(3), p.96. https://doi.org/10.1002/jib.697.
4. Natalya Pogorelova, Natalya Gavrilova. (2023). Conversion of Wheat Bran into Target Biosynthetic Products. Food Processing: Techniques and Technology, 53(1), p.49. https://doi.org/10.21603/2074-9414-2023-1-2414.
5. Konstantin Kobelev, Marina Gernet, Irina Gribkova. (2021). Innovative Method for Obtaining Biologically Active Compounds from Brewery Mash. Food Processing: Techniques and Technology, 51(1), p.113. https://doi.org/10.21603/2074-9414-2021-1-113-124.
6. Ninian Prem Prashanth Pabbathi, Aditya Velidandi, Soni Pogula, Pradeep Kumar Gandam, Rama Raju Baadhe, Minaxi Sharma, Ranjna Sirohi, Vijay Kumar Thakur, Vijai Kumar Gupta. (2022). Brewer's spent grains-based biorefineries: A critical review. Fuel, 317, p.123435. https://doi.org/10.1016/j.fuel.2022.123435.
Dimensions
PlumX
Article abstract page views
Downloads
License
Copyright (c) 2019 Andrés Alfonso Gil Montenegro, Juan Sebastian Arocha Morales, Lilia Carolina Rojas Pérez, Paulo César Narváez Rincón

This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors or holders of the copyright for each article hereby confer exclusive, limited and free authorization on the Universidad Nacional de Colombia's journal Ingeniería e Investigación concerning the aforementioned article which, once it has been evaluated and approved, will be submitted for publication, in line with the following items:
1. The version which has been corrected according to the evaluators' suggestions will be remitted and it will be made clear whether the aforementioned article is an unedited document regarding which the rights to be authorized are held and total responsibility will be assumed by the authors for the content of the work being submitted to Ingeniería e Investigación, the Universidad Nacional de Colombia and third-parties;
2. The authorization conferred on the journal will come into force from the date on which it is included in the respective volume and issue of Ingeniería e Investigación in the Open Journal Systems and on the journal's main page (https://revistas.unal.edu.co/index.php/ingeinv), as well as in different databases and indices in which the publication is indexed;
3. The authors authorize the Universidad Nacional de Colombia's journal Ingeniería e Investigación to publish the document in whatever required format (printed, digital, electronic or whatsoever known or yet to be discovered form) and authorize Ingeniería e Investigación to include the work in any indices and/or search engines deemed necessary for promoting its diffusion;
4. The authors accept that such authorization is given free of charge and they, therefore, waive any right to receive remuneration from the publication, distribution, public communication and any use whatsoever referred to in the terms of this authorization.










