Published

1999-01-01

MOLECULAR MODELING OF 1-OCTADECYL-2-METHOXYPROPYL-(N,N-DIMETHYL)- beta-HYDROXYETHYLAMMONIUM IODIDE ANALOGS AS POTENTIAL ANTITUMOR COMPOUNDS

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Authors

  • Sophie Rodriguez de L.
  • Mary I. Cordero de Tronconis
En nuestra búsqueda de nuevos compuestos con actividad antitumoral y/o anti- HIV, estudiamos nuevos análogos del Yoduro de l-Octadecil-2-Metoxipropil- (N,N - dimetil) - P - hidroxietilamonio, un éter lipídico de conocida actividad antitumoral y antiHIV. Se modelaron los compuestos propuestos, substituyendo la cadena bidrofóbica por cadenas similares a los lípidos de la membrana celular. Para el análisis conformacional se utilizaron cálculos de Mecánica Molecular y Dinámica Molecular. Las conformaciones de mínima energía obtenidas ftieron superpuestas con el compuesto de referencia, obteniéndose una buena superposición, concluyéndose que podrían presentar propiedades similares a los éteres lipidíeos en la membrana celular y por tanto son buenos candidatos para ser sintetizados.

How to Cite

IEEE

[1]
S. Rodriguez de L. and M. I. Cordero de Tronconis, “MOLECULAR MODELING OF 1-OCTADECYL-2-METHOXYPROPYL-(N,N-DIMETHYL)- beta-HYDROXYETHYLAMMONIUM IODIDE ANALOGS AS POTENTIAL ANTITUMOR COMPOUNDS”, Rev. Colomb. Quim., vol. 28, no. 1, pp. 9–18, Jan. 1999.

ACM

[1]
Rodriguez de L., S. and Cordero de Tronconis, M.I. 1999. MOLECULAR MODELING OF 1-OCTADECYL-2-METHOXYPROPYL-(N,N-DIMETHYL)- beta-HYDROXYETHYLAMMONIUM IODIDE ANALOGS AS POTENTIAL ANTITUMOR COMPOUNDS. Revista Colombiana de Química. 28, 1 (Jan. 1999), 9–18.

ACS

(1)
Rodriguez de L., S.; Cordero de Tronconis, M. I. MOLECULAR MODELING OF 1-OCTADECYL-2-METHOXYPROPYL-(N,N-DIMETHYL)- beta-HYDROXYETHYLAMMONIUM IODIDE ANALOGS AS POTENTIAL ANTITUMOR COMPOUNDS. Rev. Colomb. Quim. 1999, 28, 9-18.

APA

Rodriguez de L., S. and Cordero de Tronconis, M. I. (1999). MOLECULAR MODELING OF 1-OCTADECYL-2-METHOXYPROPYL-(N,N-DIMETHYL)- beta-HYDROXYETHYLAMMONIUM IODIDE ANALOGS AS POTENTIAL ANTITUMOR COMPOUNDS. Revista Colombiana de Química, 28(1), 9–18. https://revistas.unal.edu.co/index.php/rcolquim/article/view/17238

ABNT

RODRIGUEZ DE L., S.; CORDERO DE TRONCONIS, M. I. MOLECULAR MODELING OF 1-OCTADECYL-2-METHOXYPROPYL-(N,N-DIMETHYL)- beta-HYDROXYETHYLAMMONIUM IODIDE ANALOGS AS POTENTIAL ANTITUMOR COMPOUNDS. Revista Colombiana de Química, [S. l.], v. 28, n. 1, p. 9–18, 1999. Disponível em: https://revistas.unal.edu.co/index.php/rcolquim/article/view/17238. Acesso em: 11 aug. 2024.

Chicago

Rodriguez de L., Sophie, and Mary I. Cordero de Tronconis. 1999. “MOLECULAR MODELING OF 1-OCTADECYL-2-METHOXYPROPYL-(N,N-DIMETHYL)- beta-HYDROXYETHYLAMMONIUM IODIDE ANALOGS AS POTENTIAL ANTITUMOR COMPOUNDS”. Revista Colombiana De Química 28 (1):9-18. https://revistas.unal.edu.co/index.php/rcolquim/article/view/17238.

Harvard

Rodriguez de L., S. and Cordero de Tronconis, M. I. (1999) “MOLECULAR MODELING OF 1-OCTADECYL-2-METHOXYPROPYL-(N,N-DIMETHYL)- beta-HYDROXYETHYLAMMONIUM IODIDE ANALOGS AS POTENTIAL ANTITUMOR COMPOUNDS”, Revista Colombiana de Química, 28(1), pp. 9–18. Available at: https://revistas.unal.edu.co/index.php/rcolquim/article/view/17238 (Accessed: 11 August 2024).

MLA

Rodriguez de L., S., and M. I. Cordero de Tronconis. “MOLECULAR MODELING OF 1-OCTADECYL-2-METHOXYPROPYL-(N,N-DIMETHYL)- beta-HYDROXYETHYLAMMONIUM IODIDE ANALOGS AS POTENTIAL ANTITUMOR COMPOUNDS”. Revista Colombiana de Química, vol. 28, no. 1, Jan. 1999, pp. 9-18, https://revistas.unal.edu.co/index.php/rcolquim/article/view/17238.

Turabian

Rodriguez de L., Sophie, and Mary I. Cordero de Tronconis. “MOLECULAR MODELING OF 1-OCTADECYL-2-METHOXYPROPYL-(N,N-DIMETHYL)- beta-HYDROXYETHYLAMMONIUM IODIDE ANALOGS AS POTENTIAL ANTITUMOR COMPOUNDS”. Revista Colombiana de Química 28, no. 1 (January 1, 1999): 9–18. Accessed August 11, 2024. https://revistas.unal.edu.co/index.php/rcolquim/article/view/17238.

Vancouver

1.
Rodriguez de L. S, Cordero de Tronconis MI. MOLECULAR MODELING OF 1-OCTADECYL-2-METHOXYPROPYL-(N,N-DIMETHYL)- beta-HYDROXYETHYLAMMONIUM IODIDE ANALOGS AS POTENTIAL ANTITUMOR COMPOUNDS. Rev. Colomb. Quim. [Internet]. 1999 Jan. 1 [cited 2024 Aug. 11];28(1):9-18. Available from: https://revistas.unal.edu.co/index.php/rcolquim/article/view/17238

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